Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells (Homo sapiens)

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1MVBLateendosomeLegendESCRT-dependent pathwayProliferationEnhanced tumor growthChemoresistancePromotes EMTInhibited apoptosisRAB27AManamycinARAFMAPK1ALIXHNRNPH1BRAFRAF1RRASRRAS2MRASHRASKRASNRASMAPK3EarlyendosomeMVBRAB5ARAB5BRAB5CHGSRRASRRAS2MRASHRASKRASNRASALIXRAB27AESCRT-independent pathway


Description

Schematic representation of inhibition of exosome biogenesis and secretion by the antibiotic Manumycin A (MA) in castration-resistant prostate cancer cells (CRPC) cells. The inhibition of Ras/Raf/ERK1/2 pathway by MA leads to transcriptional down-regulation of hnRNP H1. A decrease in hnRNP H1 transcripts leads to inhibition of exosome biogenesis and secretion by suppressing ALIX and RAB27A. Description from Datta et al.

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Bibliography

  1. Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, Jones JC, Mondal D, Ferrer M, Abdel-Mageed AB; ''Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.''; Cancer Lett, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
142102view12:00, 1 December 2025EweitzClear deprecated metadata rendering
138745view01:06, 1 May 2025EweitzModified title
138744view00:59, 1 May 2025EweitzFix typo, add identifier for metabolite
134835view12:48, 27 July 2024EweitzOntology Term : 'drug pathway' added !
134834view12:47, 27 July 2024EweitzModified description
134833view12:45, 27 July 2024EweitzRefine legend
134832view12:42, 27 July 2024EweitzOntology Term : 'neoplastic cell' added !
97800view19:10, 8 June 2018KhanspersOntology Term : 'Ras family mediated signaling pathway' added !
97652view20:43, 31 May 2018KhanspersModified title
97651view20:09, 31 May 2018KhanspersOntology Term : 'prostate cancer' added !
97650view20:08, 31 May 2018KhanspersModified description
97649view20:06, 31 May 2018KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ALIXGeneProductENSG00000170248 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
HGSGeneProductENSG00000185359 (Ensembl)
HNRNPH1GeneProductENSG00000169045 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MRASGeneProductENSG00000158186 (Ensembl)
ManamycinMetabolite
NRASGeneProductENSG00000213281 (Ensembl)
RAB27AGeneProductENSG00000069974 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB5BGeneProductENSG00000111540 (Ensembl)
RAB5CGeneProductENSG00000108774 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RRAS2GeneProductENSG00000133818 (Ensembl)
RRASGeneProductENSG00000126458 (Ensembl)

Annotated Interactions

No annotated interactions

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