Endothelin pathways (Bos taurus)

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VasocontrictionSensory motor nerveEDHFCTRIIAD1NOCALCRLATP2A2L-ArginineK+PGI2cAMPRAMP1GTPK+ channelADRA1AADCY10Ca2+ channelNOS3sGCPTGIRNPY1RCOIIATPArachidonic acidCitrullineCa2+ channelK+NPYcGMPEDN1ECE1IP3CNN1PRKCAGNA15MYL1Big ET1MAP2K1EDNRAMYLKDAGMAPK1EDNRBFurin-like proteaseRAF1PLCB1IP3RPre-pro ET1CADCa2+CaMPIP2Pre-pro ET1EDN1GNB5GNG13Ca2+PMCACa2+EDNRBGNA15GNB5GNG13PLCB1PIP2IP3DAGCa2+Ca2+Ca2+ channelIP3RNOPGI2PRKCACa2+K+GNASGNB5GNG13GNA15GNB5GNG13ADRB1GNASGNB5GNG13Sympathic nerveEndothelial cellSmooth muscle cellK+CTCTGNASGNB5GNG13K+K+NPYNPYGNAI1GNB5GNG13NONOCa2+Cellular growth and survival


Description

Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2197(74852) with a 79.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
140185view05:46, 5 August 2025EgonwMore unicode
140009view05:47, 18 July 2025EgonwCalcium ion with unicode
134267view06:42, 19 July 2024EgonwRemoved template comments
117509view11:05, 21 May 2021EweitzModified title
105984view11:51, 16 August 2019MaintBotHMDB identifier normalization
80875view15:29, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY10GeneProductENSBTAG00000001052 (Ensembl)
  • adenylate cyclase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143199
ADRA1AGeneProductENSBTAG00000031632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120907
ADRB1GeneProductENSBTAG00000001242 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000043591
ATP2A2GeneProductENSBTAG00000001398 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174437
ATPMetaboliteHMDB0001532 (HMDB)
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
Big ET1Protein
CADGeneProductENSBTAG00000017894 (Ensembl)
  • Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084774
CALCRLGeneProductENSBTAG00000008483 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064989
CNN1GeneProductENSBTAG00000011207 (Ensembl)
  • Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130176
COIIGeneProductENSBTAG00000043556 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4513
CTGeneProductENSBTAG00000047380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110680
Ca2+ channelGeneProduct
Ca2+MetaboliteHMDB0000464 (HMDB)
CaMGeneProduct
CitrullineMetaboliteHMDB0000904 (HMDB)
DAGMetaboliteHMDB0007008 (HMDB)
ECE1GeneProductENSBTAG00000002977 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117298
EDHFProtein
EDN1GeneProductENSBTAG00000008096 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078401
EDNRAGeneProductENSBTAG00000013674 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151617
EDNRBGeneProductENSBTAG00000005299 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136160
Furin-like proteaseProtein
GNA15GeneProductENSBTAG00000019988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000060558
GNAI1GeneProductENSBTAG00000002714 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127955
GNASGeneProductENSBTAG00000017475 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087460
GNB5GeneProductENSBTAG00000003762 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000069966
GNG13GeneProductENSBTAG00000033526 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127588
GTPMetaboliteHMDB0001440 (HMDB)
IP3MetaboliteHMDB0001059 (HMDB)
IP3RProtein
K+ channelProtein
K+MetaboliteHMDB0000586 (HMDB)
L-ArginineMetaboliteHMDB0000517 (HMDB)
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
MYL1GeneProductENSBTAG00000009707 (Ensembl)
  • myosine light chain
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168530
MYLKGeneProductENSBTAG00000014567 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065534
NOMetaboliteHMDB0003378 (HMDB)
NOS3GeneProductENSBTAG00000017680 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164867
NPY1RGeneProductENSBTAG00000047586 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164128
NPYGeneProductENSBTAG00000004503 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122585
PGI2Metabolite
PIP2MetaboliteHMDB0010032 (HMDB)
PLCB1GeneProductENSBTAG00000008338 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182621
PMCAProtein
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229
PTGIRGeneProductENSBTAG00000014585 (Ensembl)
  • Prostaglandin I2 Receptor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160013
Pre-pro ET1Protein
RAF1GeneProductENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132155
RAMP1GeneProductENSBTAG00000011534 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132329
RIIAD1GeneProductENSBTAG00000032733 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000178796
cAMPMetaboliteHMDB0000058 (HMDB)
cGMPMetaboliteHMDB0001314 (HMDB)
sGCGeneProduct

Annotated Interactions

No annotated interactions
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