Osteoclast signaling (Homo sapiens)

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1Osteoclast activationPDGF-BB complexBoneOsteoclastTRPVTRAPPiNa+Cathepsin KCa2+PDGFBH+OsteopontinH+RANKNa+OPGIFN-bCa2+Type 1 interferon receptorOGR1H+ ATPaseNa+/H+ transporterPDGFBTRAPAIMP2b3 integrinMAPK8H+H+H+Cathepsin KRANK ligand


Description

Signaling pathways involved in osteoclast activation. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Boyle WJ, Simonet WS, Lacey DL; ''Osteoclast differentiation and activation.''; Nature, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139888view19:37, 9 July 2025EgonwMore unicode
136867view05:38, 25 February 2025EgonwModified description
126682view17:29, 11 June 2023EgonwConverted interaction type to mim-translocation
126213view13:49, 16 April 2023Egonw
116896view11:25, 15 May 2021EweitzModified title
106572view21:19, 6 September 2019KhanspersModified description
106216view12:11, 16 August 2019MaintBotHMDB identifier normalization
105767view19:37, 15 August 2019KhanspersModified description
97823view15:29, 9 June 2018EgonwUndo revision 97754 by [[Special:Contributions/Jessev1993|Jessev1993]] ([[User talk:Jessev1993|Talk]]) Text cannot be copied from other websites.
97754view13:18, 7 June 2018Jessev1993Modified description
97753view13:17, 7 June 2018Jessev1993added references
88602view20:04, 11 August 2016Mkutmonfix unconnected lines
81176view13:30, 31 July 2015EgonwPubChem-compound ID for H+ (hydron) instead of the hydrogen radical.
78593view14:51, 7 January 2015MaintBotadded missing graphIds
72135view08:17, 25 October 2013EgonwAdded an identifier for Pi.
68910view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67557view11:25, 26 June 2013DdiglesOntology Term : 'signaling pathway pertinent to development' added !
59108view22:20, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48235view05:51, 17 May 2012MaintBotUpdating PubChem xrefs
48213view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45320view20:10, 7 October 2011KhanspersOntology Term : 'signaling pathway' added !
45318view20:08, 7 October 2011KhanspersOntology Term : 'osteoclast' added !
43865view23:57, 9 August 2011Samuel SklarSpecify description
43864view23:56, 9 August 2011Samuel SklarPeriodical save, work in progress
41056view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39760view07:33, 17 January 2011AlexanderPicomore specific title
38787view00:25, 24 September 2010AlexanderPico
38786view00:24, 24 September 2010AlexanderPico
38785view00:22, 24 September 2010AlexanderPico
38784view00:21, 24 September 2010AlexanderPicoSpecify description
38783view00:20, 24 September 2010AlexanderPico
38781view00:18, 24 September 2010AlexanderPicoSpecify description
38780view00:15, 24 September 2010AlexanderPicobeautification
20697view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Osteoclasts]] moved to [[Pathway:WP12]]: Moved to stable identifier
14749view22:51, 23 May 2008EhsiaoConnected
10392view02:54, 25 January 2008AlexanderPicoadded id for na+/h+ transporter
10391view02:46, 25 January 2008AlexanderPicoupdated identifiers and data types
10390view02:41, 25 January 2008AlexanderPicoupdating identifiers and data types
10358view03:01, 23 January 2008AlexanderPicoModified categories
10335view01:33, 23 January 2008EhsiaoGPML Import (Author=Grant Yang)

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AIMP2GeneProductENSG00000106305 (Ensembl)
Ca2+Metabolite271 (PubChem-compound)
Cathepsin KProtein1513 (Entrez Gene)
H+ ATPaseProtein9550 (Entrez Gene)
H+Metabolite1038 (PubChem-compound)
IFN-bProtein3456 (Entrez Gene)
MAPK8GeneProductENSG00000107643 (Ensembl)
Na+/H+ transporterProtein6548 (Entrez Gene)
Na+MetaboliteHMDB0000588 (HMDB)
OGR1Protein8111 (Entrez Gene)
OPGProtein4982 (Entrez Gene)
OsteopontinProtein6696 (Entrez Gene)
PDGFBProtein5155 (Entrez Gene)
PiMetaboliteCHEBI:35780 (ChEBI)
RANK ligandProtein8600 (Entrez Gene)
RANKProtein8792 (Entrez Gene)
TRAPProtein54 (Entrez Gene)
TRPVProtein56302 (Entrez Gene)
Type 1 interferon receptorProtein3454 (Entrez Gene)
b3 integrinProtein3690 (Entrez Gene)

Annotated Interactions

No annotated interactions

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