Urotensin-II-mediated signaling (Homo sapiens)

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ROSPrimary Kupffer cells Human coronary artery endothelial cells LigandRAW264.7 macrophages NADPHDownregulatedGNAQ mediated activationGene regulationLiver injury and acute liver failure DissociationKidneyMyocardial damage in atherosclerotic ratsPhosphorylationCell proliferationReactive oxygen species (ROS)ReceptorInhibitionNPPACYBAPCNACATNCF2BCL2CASP3SOD2CYBBCASP9HMOX1NCF4NCF1BAXCAMKIIAT286PLCAKT1S473PT308CYBAIFN-γ HSPA2MAPK3T202Y204MMP9IL1β Atherosclerosis and fibrosisNCF1CYBBCOL1A1THP1-Monocytes and macrophagesCREBS133UTRCOL3A1LTB4AGTR1CBPIL-6ACTA2PRKACAPCCNE1ABCA1CDK1ALOX5MMP9TNFTFPRKACANCF1IL6ICAM1p300TNF-alphaCOL4A1MMP2IFNBUrotensin-IICOL2A1NOX4TRPC4MAPK1Y187T185VCAM1CDK2ProteinPTGFB1FN1A1FM2DDIT3NCF4ESPL1UpregulatedIL1BJAK2T1007PSTAT3T705PSTAT3MAPK8PY185MAPK9PT183MAPK14PNFKB1PNFKB1APERK and IL-1ß pathway activation FibroblastsTGFB1SMAD3SMAD2Proliferation,neuropathy development, vascular fibrosis and collagen synthesisTGFB1Urotensin-IIUTRMAPK1Y187T185MAPK3Y204T202RELARELAS536PNFKB1AS32PIRF3Translocation from CP to NUTranslocation from CP to NUDissociationNFKB1RHOAMAPK8PY185MAPK9T183PInflammationCardiac hypertrophyNPPBNPPAMAPK1T185Y187MAPK3PT202Y204MAPK14PY182T180Urotensin-IIUTREGFRY1068PROSPTPN11HypertrophyCHUKS176PIKBKBS180PGSK3BS9PGSK3APS21NFKB1RELAHDAC5HDAC5S493PNFKB1ANFKB1AKT1S473PATP2A2CAMK2APT286PLNT17PCa2+Inhibits dephosphorylation activity of PTPN11Hemodynamic effectsPIP2PI3KCAPPIP3PTENPTENPCTNNB1FN1COL1A1COL3A1Cardiac hypertrophyUrotensin-IIUTRMAPK1T185Y187MAPK3Y204T202MAPK8PY185MAPK9T183PAKT1PS473PI3KCAPCYBBFSCN1ROSNCF1NADPH++H+O2Cell invasion and migrationCY to PMNFKB1PNFKB1APDissociationNFKB1CancerUrotensin-IIUTRCREBCa2+IP3Endoplasmic reticulam stressEpithelial-mesenchymal transitionCOL4A1FN1Aristoiochic acid nephropathyProliferationExtracellular matric protein accumulationTranslocation from CP to NUGANQTranslocation from CP to NUTranslocation from nucleus(NU) to cytoplasm (CP)RELACardiac hypertrophyMyocardial fibrosis and hypertrophyInhibition of PTEN leads to activation of AKT1/GSK3BIRF3IL1β TNF-alphaPromote the release of inflammatory cytokinsDissociationKidney diseaseMAPK14Y182PT180TRPC4 channel-mediated store-operated Ca2+ entry (SOCE) and sequential activation of CaMKIIPRKACAProduction against ischemic reperfusion injuryTranslocation from CP to NUTranslocation from NU to CPTranslocation from cytoplasm (CP) to nucleus (NU)ROS mediated activationTranslocation from cytoplasm (CP) to plasma membrane (PM)ActivationFigure legend


Description

Schematic representation of Urotensin-II-mediated signaling pathway

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Bibliography

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  1. Gong H, Chen Z, Zhang X, Li Y, Zhang J, Chen Y, Ding Y, Zhang G, Yang C, Zhu Y, Zou Y; ''Urotensin II Protects Cardiomyocytes from Apoptosis Induced by Oxidative Stress through the CSE/H2S Pathway.''; Int J Mol Sci, 2015 PubMed Europe PMC Scholia
  2. Liang DY, Liu LM, Ye CG, Zhao L, Yu FP, Gao DY, Wang YY, Yang ZW; ''Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-κB pathway in ALF mice.''; PLoS One, 2014 PubMed Europe PMC Scholia
  3. Bianca Rd, Mitidieri E, Fusco F, D'Aiuto E, Grieco P, Novellino E, Imbimbo C, Mirone V, Cirino G, Sorrentino R; ''Endogenous urotensin II selectively modulates erectile function through eNOS.''; PLoS One, 2012 PubMed Europe PMC Scholia
  4. Trebicka J, Leifeld L, Hennenberg M, Biecker E, Eckhardt A, Fischer N, Pröbsting AS, Clemens C, Lammert F, Sauerbruch T, Heller J; ''Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats.''; Hepatology, 2008 PubMed Europe PMC Scholia
  5. Zhou CH, Wan YY, Chu XH, Song Z, Xing SH, Wu YQ, Yin XX; ''Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice.''; Oncol Lett, 2012 PubMed Europe PMC Scholia
  6. Diebold I, Petry A, Burger M, Hess J, Görlach A; ''NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II.''; Mol Biol Cell, 2011 PubMed Europe PMC Scholia
  7. Segain JP, Rolli-Derkinderen M, Gervois N, Raingeard de la Blétière D, Loirand G, Pacaud P; ''Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.''; J Immunol, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
137394view23:25, 1 March 2025EweitzRemove obsolete metadata fields
137393view23:24, 1 March 2025EweitzEconomize layout
129675view00:45, 22 May 2024EweitzModified title
126484view16:57, 8 May 2023Khanspersremove labels as identifiers from xrefs
126369view17:47, 25 April 2023EgonwNot a mim-conversion
126326view20:57, 21 April 2023KhanspersOntology Term : 'signaling pathway' added !
126325view20:21, 21 April 2023Khanspersxrefs
126315view23:46, 20 April 2023Khanspersxrefs
126314view23:10, 20 April 2023Khanspersmore xrefs
126313view21:08, 20 April 2023Khanspersmore xrefs
126287view05:24, 20 April 2023Khanspersmore xrefs
126260view22:29, 18 April 2023Khanspersadded xrefs to first box
126259view22:06, 18 April 2023Khanspersconnected interactions, converted to graphical line where appropriate
122561view08:39, 16 April 2022EgonwRemove gene symbols which are not valid identifiers in the stated data sources
120968view06:29, 4 February 2022Keshav
120925view19:20, 31 January 2022EgonwFixed the data sources for UniProt identifiers
120900view08:22, 29 January 2022KeshavModified title
120899view08:20, 29 January 2022KeshavNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
A1FM2GeneProductA1FM2
ABCA1GeneProduct19 (Entrez Gene)
ACTA2GeneProductACTA2
AGTR1GeneProduct185 (Entrez Gene)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALOX5GeneProduct240 (Entrez Gene)
ATP2A2Protein
BAXGeneProduct581 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
CAMK2AProteinQ7LDD5 (Uniprot-TrEMBL)
CAMKIIAGeneProductQ7LDD5 (Uniprot-TrEMBL)
CASP3GeneProduct836 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CATGeneProductCAT
CBPGeneProductCBP
CCNE1GeneProduct898 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CHUKProteinO15111 (Uniprot-TrEMBL)
COL1A1GeneProduct1277 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
COL4A1GeneProduct1277 (Entrez Gene)
CREBGeneProductCREB
CTNNB1GeneProduct1499 (Entrez Gene)
CYBAGeneProduct1535 (Entrez Gene)
CYBBGeneProduct1536 (Entrez Gene)
DDIT3GeneProductDDIT3
EGFRProteinP00533 (Uniprot-TrEMBL)
ESPL1GeneProductESPL1
FN1GeneProduct2335 (Entrez Gene)
FSCN1GeneProduct6624 (Entrez Gene)
GANQProteinGANQ
GSK3AProteinP49840 (Uniprot-TrEMBL)
GSK3BProteinP49841 (Uniprot-TrEMBL)
HDAC5ProteinQ9UQL6 (Uniprot-TrEMBL)
HMOX1GeneProduct3162 (Entrez Gene)
HSPA2GeneProductHSPA2
ICAM1GeneProductICAM1
IFN-γ GeneProductIFN-γ
IFNBGeneProduct
IKBKBProteinO14920 (Uniprot-TrEMBL)
IL-6GeneProductIL-6
IL1BGeneProduct3553 (Entrez Gene)
IL1β GeneProductIL1β
IL6GeneProduct3569 (Entrez Gene)
IRF3GeneProduct
JAK2ProteinO60674 (Uniprot-TrEMBL)
LTB4GeneProduct
MAPK14ProteinQ16539 (Uniprot-TrEMBL)
MAPK14Protein
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MAPK8ProteinP45983 (Uniprot-TrEMBL)
MAPK9ProteinP45984 (Uniprot-TrEMBL)
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
NCF1GeneProduct653361 (Entrez Gene)
NCF2GeneProduct4688 (Entrez Gene)
NCF4GeneProduct4689 (Entrez Gene)
NFKB1AProteinNFKB1A (HGNC)
NFKB1AProtein
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NOX4GeneProduct50507 (Entrez Gene)
NPPAGeneProduct4878 (Entrez Gene)
NPPAGeneProductNPPA
NPPBGeneProduct4879 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
PI3KCAProtein
PIP2Protein
PIP3Protein
PLCGeneProductPLC
PLNProteinP26678 (Uniprot-TrEMBL)
PRKACAGeneProduct5566 (Entrez Gene)
PRKACAProteinP17612 (Uniprot-TrEMBL)
PTENGeneProduct5728 (Entrez Gene)
PTENProteinP60484 (Uniprot-TrEMBL)
PTPN11ProteinQ06124 (Uniprot-TrEMBL)
ProteinGeneProduct
RELAProteinQ04206 (Uniprot-TrEMBL)
RELAProtein
RHOAProteinP61586 (Uniprot-TrEMBL)
SMAD2GeneProductSMAD2 (HGNC)
SMAD3GeneProduct4088 (Entrez Gene)
SOD2GeneProductSOD2
STAT3Protein6774 (Entrez Gene)
STAT3ProteinP40763 (Uniprot-TrEMBL)
TFGeneProductTF
TGFB1GeneProduct7040 (Entrez Gene)
TNF-alphaGeneProductTNF-alpha
TNFGeneProduct7124 (Entrez Gene)
TRPC4ProteinQ9UBN4 (Uniprot-TrEMBL)
UTRProteinQ9UKP6 (Uniprot-TrEMBL)
Urotensin-IIProteinO95399 (Uniprot-TrEMBL)
VCAM1GeneProduct
p300GeneProductp300

Annotated Interactions

No annotated interactions

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