Protein alkylation leading to liver fibrosis (Homo sapiens)

From WikiPathways

Revision as of 13:09, 28 February 2023 by Marvin M2 (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
1KE244: Protein alkylationApoptosisCCl4KE55: Cell injury/deathApoptosis Modulation and SignalingKE134: Increased activation and recruitment of Kupffer CellsKE265: Stellate cell activationDimethylnitrosamineallyl alcoholKE276: TGFbeta1 expression up regulationKE344: Liver FibrosisretinolthioacetamideTNF alpha Signaline PathwayCollagen biosynthesis and modifying enzymesKE68: Collagen accumulationTGF-beta signaling pathway


Description

Protein alkylation leading to liver fibrosis This pathway is based on descriptive text of the adverse outcome pathway (AOP) on https://aopwiki.org/aops/38

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

  1. Horvat T, Landesmann B, Lostia A, Vinken M, Munn S, Whelan M; ''Adverse outcome pathway development from protein alkylation to liver fibrosis.''; Arch Toxicol, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125572view13:09, 28 February 2023Marvin M2created event nodes
125571view13:07, 28 February 2023Marvin M2added KE nodes
125570view12:50, 28 February 2023Marvin M2Added tgf-beta pathway
114317view16:15, 6 January 2021Marvin M2Updated layout
114316view16:06, 6 January 2021Marvin M2Renewed and removed molecular entities to follow AOP guidelines
96718view16:23, 30 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96693view15:51, 27 March 2018Marvin M2Added references to Key Events and Key Event Relationships
93134view13:39, 31 July 2017Marvin M2Added the main reference for this AOP
92321view11:11, 22 May 2017Marvin M2Ontology Term : 'liver disease pathway' added !
92320view11:04, 22 May 2017Marvin M2Ontology Term : 'liver disease' added !
92296view12:59, 19 May 2017Marvin M2Modified description
92294view12:47, 19 May 2017Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apoptosis Modulation and SignalingPathwayWP1772 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
CCl4MetaboliteCHEBI:27385 (ChEBI)
Collagen biosynthesis and modifying enzymesPathwayWP2725 (WikiPathways)
DimethylnitrosamineMetaboliteCHEBI:35807 (ChEBI)
KE134: Increased activation and recruitment of Kupffer CellsEvent134 (AOP-Wiki KE)
KE244: Protein alkylationEvent244 (AOP-Wiki KE)
KE265: Stellate cell activationEvent265 (AOP-Wiki KE)
KE276: TGFbeta1 expression up regulationEvent276 (AOP-Wiki KE)
KE344: Liver FibrosisEvent344 (AOP-Wiki KE)
KE55: Cell injury/deathEvent55 (AOP-Wiki KE)
KE68: Collagen accumulationEvent68 (AOP-Wiki KE)
TGF-beta signaling pathwayPathwayWP366 (WikiPathways)
TNF alpha Signaline PathwayPathwayWP231 (WikiPathways)
allyl alcoholMetaboliteCHEBI:16605 (ChEBI)
retinolMetaboliteCHEBI:50211 (ChEBI)
thioacetamideMetaboliteQ416253 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP3980"
Personal tools