Pyruvate dehydrogenase pathway (Saccharomyces cerevisiae)

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NADS-AcetyldihydrolipoamidepyruvateH+CO2Coenzyme APDA1NADHlipoamidelipoamidePDB1acetyl-CoALPD1LAT1dihydrolipoamide


Description

Pyruvate dehydrogenase is a multiple enzyme complex that catalyzes the production of acetyl-CoA from pyruvate produced by glycolysis. The final step re-oxidizes the lipoyl group of dihydrolipoamide to form lipoamide and NADH.

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Ontology Terms

 

Bibliography

  1. ''Pyruvate decarboxylation to acetyl CoA''; YeastPathways,
  2. Pronk JT, Yde Steensma H, Van Dijken JP; ''Pyruvate metabolism in Saccharomyces cerevisiae.''; Yeast, 1996 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141779view07:26, 23 November 2025EgonwAdded a reference
140404view13:56, 17 August 2025EgonwMore unicode
135426view21:17, 5 September 2024KhanspersOntology Term : 'classic metabolic pathway' added !
135425view21:16, 5 September 2024Khanspersupdated lit ref
135424view21:15, 5 September 2024Khanspersoverhaul
125509view01:42, 24 February 2023AlexanderPicoadded description
117331view11:49, 20 May 2021EweitzModified title
107013view13:47, 17 September 2019MaintBotHMDB identifier normalization
97074view16:17, 26 April 2018MaxvansonDefined metabolites and added in IDs.
97065view15:37, 26 April 2018MaxvansonEdit description Changed some metabolities to make it usable for pathway analysis. Connected lines which where unconnected.
69823view14:42, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69675view20:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67619view11:34, 26 June 2013DdiglesOntology Term : 'pyruvate metabolic pathway' added !
41920view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
21129view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Pyruvate Dehydrogenase Pathway]] moved to [[Pathway:WP214]]: Moved to stable identifier
12830view08:04, 17 May 2008MaintBotautomated metabolite conversion
8900view14:11, 7 January 2008MaintBotAdded to category $category
8898view14:11, 7 January 2008J.HeckmanUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Coenzyme AMetabolite64885-97-8 (CAS)
LAT1GeneProductS000005015 (SGD)
LPD1GeneProductS000001876 (SGD)
NADMetaboliteCHEBI:13389 (ChEBI)
NADHMetabolite53-84-9 (CAS)
PDA1GeneProductS000000980 (SGD)
PDB1GeneProductS000000425 (SGD)
S-AcetyldihydrolipoamideMetaboliteHMDB0001526 (HMDB)
acetyl-CoAMetabolite72-89-9 (CAS)
dihydrolipoamideMetabolite3884-47-7 (CAS)
lipoamideMetabolite940-69-2 (CAS)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP214"
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