Carnosine metabolism of glial cells (Homo sapiens)

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3, 4, 6Blood Brain BarrierOligodendrocyteAstrocyteIntestinesLiverMacrophages & Microglia Uracil and Thymine degradation 1355Carnosine degradation BETA-ALANINEGLT-1lactateATPSLC6A6SLC1A4CARNS1glutamateCN1SLC1A5CarnosineL-carnosineL-histidineATPaseCarnosineADPNa+Lactate ShuttleSLC7A5GlycolysisBETA-ALANINE222SLC15A2SLC15A2SLC15A2SLC15A4L-histidineNa+glutamateATPADPCN2


Description

Carnosine Metabolism of Glial Cells

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Caruso G, Caraci F, Jolivet RB; ''Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders.''; Prog Neurobiol, 2019 PubMed Europe PMC Scholia
  2. Usui T, Kubo Y, Akanuma S, Hosoya K; ''Β-alanine and l-histidine transport across the inner blood-retinal barrier: potential involvement in L-carnosine supply.''; Exp Eye Res, 2013 PubMed Europe PMC Scholia
  3. Jukić I, Kolobarić N, Stupin A, Matić A, Kozina N, Mihaljević Z, Mihalj M, Šušnjara P, Stupin M, Ćurić ŽB, Selthofer-Relatić K, Kibel A, Lukinac A, Kolar L, Kralik G, Kralik Z, Széchenyi A, Jozanović M, Galović O, Medvidović-Kosanović M, Drenjančević I; ''Carnosine, Small but Mighty-Prospect of Use as Functional Ingredient for Functional Food Formulation.''; Antioxidants (Basel), 2021 PubMed Europe PMC Scholia
  4. Zaragozá R; ''Transport of Amino Acids Across the Blood-Brain Barrier.''; Front Physiol, 2020 PubMed Europe PMC Scholia
  5. Solana-Manrique C, Sanz FJ, Martínez-Carrión G, Paricio N; ''Antioxidant and Neuroprotective Effects of Carnosine: Therapeutic Implications in Neurodegenerative Diseases.''; Antioxidants (Basel), 2022 PubMed Europe PMC Scholia
  6. Schön M, Mousa A, Berk M, Chia WL, Ukropec J, Majid A, Ukropcová B, de Courten B; ''The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence.''; Nutrients, 2019 PubMed Europe PMC Scholia
  7. Boldyrev AA, Aldini G, Derave W; ''Physiology and pathophysiology of carnosine.''; Physiol Rev, 2013 PubMed Europe PMC Scholia
  8. Ouyang L, Tian Y, Bao Y, Xu H, Cheng J, Wang B, Shen Y, Chen Z, Lyu J; ''Carnosine decreased neuronal cell death through targeting glutamate system and astrocyte mitochondrial bioenergetics in cultured neuron/astrocyte exposed to OGD/recovery.''; Brain Res Bull, 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140540view06:19, 9 September 2025EgonwOne more Na⁺
140539view06:18, 9 September 2025EgonwMore mim-translocations
140229view06:48, 8 August 2025EgonwMore unicode
127653view23:23, 13 November 2023Khanspersremoved unecessary WPID references
125782view09:46, 10 March 2023IsabelWassinkOntology Term : 'glial cell' added !
125780view09:45, 10 March 2023IsabelWassinkOntology Term : 'classic metabolic pathway' added !
125592view06:42, 3 March 2023EgonwNot a mim-conversion
125591view06:33, 3 March 2023EgonwRemoved two template comments
125590view06:24, 3 March 2023EgonwRemoved two incorrect identifiers
125524view16:47, 25 February 2023EgonwMade two pathways clickable
125257view09:39, 31 January 2023TichaLink to lactate shuttle
125256view09:32, 31 January 2023Jasmijnvanzaanenmoving of metabolites
125255view09:26, 31 January 2023Jasmijnvanzaanenadding links to pathways
125183view12:00, 27 January 2023Jasmijnvanzaanenadding metabolites
125182view11:54, 27 January 2023Jasmijnvanzaanenadding description of pathway
125127view14:06, 24 January 2023Jasmijnvanzaanenmoving transporters and adding literature
125108view11:17, 23 January 2023Tichalocation of transporter
125102view00:40, 23 January 2023EweitzModified title
125083view13:50, 20 January 2023TichaUpdate on some Genes
125076view10:30, 20 January 2023TichaColor and CNDP1
125067view12:14, 18 January 2023TichaAdd transporters in BBB for Amino acids to pass
125066view11:56, 18 January 2023Jasmijnvanzaanenadding arrows
125065view11:47, 18 January 2023Jasmijnvanzaanenadding connection to lactate shuttle
125059view19:03, 17 January 2023Tichaoutline changes
125058view18:32, 17 January 2023Tichaaddition of carnosinases, blood brain barrier
125055view15:26, 17 January 2023Tichachanges and additions
125054view14:55, 17 January 2023Jasmijnvanzaanenmoving transporters
125039view10:13, 17 January 2023Jasmijnvanzaanenadding literature references
125029view09:20, 16 January 2023Jasmijnvanzaanenadding identifiers to each node.
125028view09:13, 16 January 2023JasmijnvanzaanenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:456216 (ChEBI)
ATPMetaboliteCHEBI:30616 (ChEBI)
ATPaseProtein
BETA-ALANINEMetaboliteCHEBI:16958 (ChEBI)
CARNS1GeneProductENSG00000172508 (Ensembl)
CN1GeneProductCN1 (Ensembl)
CN2GeneProductCN1 (Ensembl)
Carnosine degradation Pathway
CarnosineMetaboliteCHEBI:15727 (ChEBI)
GLT-1GeneProduct
GlycolysisPathway
L-carnosineMetaboliteCHEBI:15727 (ChEBI)
L-histidineMetaboliteCHEBI:15971 (ChEBI)
Lactate ShuttlePathway
Na+MetaboliteCHEBI:29101 (ChEBI)
SLC15A2GeneProductENSG00000163406 (Ensembl)
SLC15A4GeneProductENSG00000139370 (Ensembl)
SLC1A4GeneProduct
SLC1A5GeneProduct
SLC6A6GeneProductENSG00000131389 (Ensembl)
SLC7A5GeneProduct
glutamateMetaboliteCHEBI:14321 (ChEBI)
lactateMetaboliteCHEBI:24996 (ChEBI)

Annotated Interactions

No annotated interactions

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