GABA receptor signaling (Homo sapiens)

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1UbAP2LegendGlial cellclathrin-coated vesicleExtracellular spacenerve terminalclathrin-coated pitGABA-A-receptorCytoplasmTranslocation/Transportadenylate cyclaseGABRQALDH9A1ALDH4GABRPGABRB3L-glutamateNSFgamma-hydroxybutyrate GPHNK+ channelcitrate cycleGADG-protein (small monomeric Small GTPase)VIAATG-protein (large Heterotrimeric)ABATGABREGAD1GAD2AP2A1GABRG1GABRB2GABARAPSLC6A11Cl-BarbituratesAP2A2Ca2+ channelGABRDsuccinate GABRG2ABATsuccinic semialdehydeDNM1SLC32A1AP2S1GABA-B-receptorcalcium influxbenzodiazepinesBaclofenAP2B1GABRG3GABRB1GABAUBQLN1AP2M1GAT1GABRA1synapsePresynaptic neuronSynaptic vesicleGABAGABArelease of GABAGABAGAT3GABAALDH9A1gamma-hydroxybutyrate ABATsuccinate citrate cyclesuccinic semialdehydeALDH4ABATPostsynaptic neuronGABA-B-receptor (sub.1)GABACl-Cl-Cl-Cl-golgiGABA-B-receptor (sub.2)GABA-B-receptor (sub.1)GABA-B-receptor (sub.2)GABRA3GABRA5GABRA2GABRA4GABRA6UbGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorGABA-A-receptorAP2GABARAPNSFUBQLN1GPHNGABARAP


Description

GABA is the main inhibitory neurotransmitter in the mammalian CNS. It is synthesized from glutamate by the enzyme L-glutamic acid decarboxylase. The GABA transporter GAT, located in the plasma membrane of nerve terminals and glial cells, plays an important role in the termination of synaptic transmission. GABA enters the cell via GAT and is then converted to gamma hydroxybutarate or succinate, the latter eventually entering the citrate cycle.

There are three GABA receptors: GABA(A), GABA(B) and GABA(C) receptor. GABA(A) and GABA(C) receptors belong to the family of transmitter-gated ion channels while GABA(B) receptor is a G protein coupled receptor which is activated by baclofen. GABA(A) receptors are hetero-oligomeric Cl- channels that are modulated by barbiturates and benzodiazepines. GABA(A)R-associated protein (GABARAP) is localized in the golgi and plays a role in intracellular GABA (A) receptor transport via its ability to interact with N-ethylmaleimide-sensitive factor (NSF) and gephyrin (GPHN). Surface receptor number is important since it is a determinant of inhibitory synapse strength. It is controlled by removal of receptors from the membrane by interaction with the clathrin adaptor AP2 followed by recruitment into clathrin-coated pits. GABA(A) receptors can then be targeted for proteasomal degradation.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. ''''; https://targetexplorer.ingenuity.com/pathway/ING/ING:cih#!/api/rest/v1/client/searchPathwayNodes?pathwayId=ING:cih&rows=0&facetLimit=5000&responseType=default,

History

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CompareRevisionActionTimeUserComment
140746view05:46, 19 October 2025EgonwCl⁻ unicode
138618view11:34, 23 April 2025EweitzPad cell compartment
138617view11:33, 23 April 2025EweitzFix PathVisio / Kaavio graphical discrepancy
138616view11:32, 23 April 2025EweitzRefine legend
138615view11:29, 23 April 2025EweitzIncrease height of receptor nodes
138614view11:28, 23 April 2025EweitzRefine membrane position
138613view11:26, 23 April 2025EweitzRefine node labels
138612view11:24, 23 April 2025EweitzRefine layering
138611view11:23, 23 April 2025EweitzEconomize layout
138610view11:18, 23 April 2025EweitzEconomize layout
138609view11:12, 23 April 2025EweitzEconomize layout
138608view04:06, 23 April 2025EweitzStandardize case
138607view04:06, 23 April 2025EweitzEconomize layout
138606view04:03, 23 April 2025EweitzEconomize layout
138605view03:31, 23 April 2025EweitzEconomize layout
138604view03:27, 23 April 2025EweitzTailor node dimensions
138603view03:26, 23 April 2025EweitzDecrease node height
138602view03:25, 23 April 2025EweitzDecrease node height
138601view02:35, 23 April 2025EweitzOntology Term : 'glial cell' added !
138600view02:35, 23 April 2025EweitzOntology Term : 'neuron' added !
138599view02:34, 23 April 2025EweitzStandardize case
137939view18:36, 10 March 2025KhanspersModified description
128692view20:18, 19 February 2024EgonwReplaced an replaced Wikidata identifier
124609view19:47, 15 November 2022EgonwReplaced an old Wikidata identifier
123439view04:38, 27 July 2022EgonwMade two pathways clickable
123430view06:40, 26 July 2022EgonwTyped two datanodes
119288view11:01, 23 June 2021Finterlymoved url info to Source for PublicationXref
117730view12:37, 22 May 2021EweitzModified title
107556view23:56, 19 October 2019AlexanderPicoremoved incomplete and duplicate description
106425view23:19, 28 August 2019KhanspersModified description
105601view04:50, 10 August 2019KhanspersModified description
97503view13:28, 24 May 2018IreneHemelAddition of two GAD isoforms
94955view12:23, 19 October 2017DeSlOntology Term : 'synaptic vesicle exocytosis - neurotransmitter release pathway' added !
94954view12:22, 19 October 2017DeSlOntology Term : 'neurotransmitter metabolic pathway' added !
94953view12:21, 19 October 2017DeSlOntology Term : 'calcium channel blocker drug pathway' added !
94952view12:18, 19 October 2017DeSladded missing IDs for nodes, changed datasource annotation to wikidata where needed.
94951view12:08, 19 October 2017DeSladded all nodes from ref.
94950view10:05, 19 October 2017DeSlAdded part of PW in postsynaptic neuron.
94931view14:00, 13 October 2017DeSlOntology Term : 'gamma-aminobutyric acid signaling pathway' added !
94930view13:58, 13 October 2017DeSlOntology Term : 'benzodiazepine pharmacodynamics pathway' added !
94929view13:57, 13 October 2017DeSlOntology Term : 'GABAergic neuron' added !
94928view13:56, 13 October 2017DeSlOntology Term : 'signaling pathway' added !
94927view13:54, 13 October 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABATProteinP80404 (Uniprot-TrEMBL) 4-Aminobutyrate aminotransferase
ABATGeneProductQ18300885 (Wikidata)
ALDH4ProteinP49189 (Uniprot-TrEMBL) 4-trimethylaminobutyraldehyde dehydrogenase
ALDH9A1GeneProductENSG00000143149 (Ensembl)
AP2A1GeneProductENSG00000196961 (Ensembl)
AP2A2GeneProduct161 (Entrez Gene)
AP2B1GeneProductENSG00000006125 (Ensembl)
AP2M1GeneProductENSG00000161203 (Ensembl)
AP2S1GeneProductENSG00000042753 (Ensembl)
BaclofenMetaboliteQ413717 (Wikidata)
BarbituratesMetaboliteQ206348 (Wikidata)
Ca2+ channelProteinQ246819 (Wikidata)
Cl-MetaboliteQ108200 (Wikidata)
DNM1GeneProductQ1181014 (Wikidata)
G-protein (large Heterotrimeric)Protein3.6.5.1 (Enzyme Nomenclature) guanine nucleotide-binding proteins
G-protein (small monomeric Small GTPase)Protein3.6.5.2 (Enzyme Nomenclature) guanine nucleotide-binding proteins
GABA-B-receptor (sub.1)ProteinQ9UBS5 (Uniprot-TrEMBL)
GABA-B-receptor (sub.2)ProteinO75899 (Uniprot-TrEMBL)
GABA-B-receptorProteinQ9UBS5 (Uniprot-TrEMBL)
GABAMetaboliteQ210021 (Wikidata)
GABARAPGeneProductQ18036482 (Wikidata)
GABRA1ProteinENSG00000022355 (Ensembl)
GABRA2ProteinENSG00000151834 (Ensembl)
GABRA3ProteinENSG00000011677 (Ensembl)
GABRA4ProteinENSG00000109158 (Ensembl)
GABRA5ProteinENSG00000186297 (Ensembl)
GABRA6ProteinQ16445 (Uniprot-TrEMBL)
GABRB1ProteinENSG00000163288 (Ensembl)
GABRB2ProteinENSG00000145864 (Ensembl)
GABRB3ProteinENSG00000166206 (Ensembl)
GABRDProteinENSG00000187730 (Ensembl)
GABREProteinENSG00000102287 (Ensembl)
GABRG1ProteinENSG00000163285 (Ensembl)
GABRG2ProteinENSG00000113327 (Ensembl)
GABRG3ProteinENSG00000182256 (Ensembl)
GABRPProteinENSG00000094755 (Ensembl)
GABRQProteinENSG00000268089 (Ensembl)
GAD1GeneProductQ99259 (Uniprot-TrEMBL)
GAD2GeneProductQ05329 (Uniprot-TrEMBL)
GADProtein4.1.1.15 (Enzyme Nomenclature) glutamic acid decarboxylase
GAT1GeneProductP30531 (Uniprot-TrEMBL)
GAT3ProteinP48066 (Uniprot-TrEMBL)
GPHNGeneProductENSG00000171723 (Ensembl)
K+ channelProteinQ42262185 (Wikidata)
L-glutamateMetaboliteQ27104095 (Wikidata)
NSFGeneProductQ6951477 (Wikidata)
SLC32A1GeneProductENSG00000101438 (Ensembl)
SLC6A11GeneProductENSG00000132164 (Ensembl)
UBQLN1GeneProductQ18039745 (Wikidata)
VIAATProteinQ9H598 (Uniprot-TrEMBL) Vesicular inhibitory amino acid transporter
adenylate cyclaseProteinQ356257 (Wikidata)
benzodiazepinesMetaboliteQ83871 (Wikidata)
calcium influxMetaboliteQ23905776 (Wikidata)
citrate cyclePathwayWP78 (WikiPathways)
gamma-hydroxybutyrate MetaboliteQ207920 (Wikidata)
release of GABAMetaboliteQ210021 (Wikidata)
succinate MetaboliteQ213050 (Wikidata)
succinic semialdehydeMetaboliteQ4602542 (Wikidata)

Annotated Interactions

No annotated interactions

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