Glycosphingolipid metabolism (Homo sapiens)

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2135644A3GALT2GBA3GalCerGlcCerARSAGLALacto seriesLacCerB4GALT4Gala-SeriesGlobo seriesA4GALTGA2GBA1B4GALNT1iGb3GM4B3GALT2SM3B4GALT1Lc3CerUGCGGanglio seriesSM4Gb3B3GALT1B4GALT3A4GALTCDGGAL3ST1Neolacto seriesGBA2nLc4CerCeramideB3GNT5LM1GALCB4GALT5UGT8B4GALT6GM36ST3GAL5GAL3ST1ST3GAL5isoGlobo series


Description

Glycosphingolipid metabolism, based on sphingomap. Initial top level pathway

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Merril AH Jr; ''SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids.''; Glycobiology, 2005 PubMed Europe PMC Scholia
  2. Wenger DA, Sattler M, Hiatt W; ''Globoid cell leukodystrophy: deficiency of lactosyl ceramide beta-galactosidase.''; Proc Natl Acad Sci U S A, 1974 PubMed Europe PMC Scholia
  3. Kase R, Bierfreund U, Klein A, Kolter T, Utsumi K, Itoha K, Sandhoff K, Sakuraba H; ''Characterization of two alpha-galactosidase mutants (Q279E and R301Q) found in an atypical variant of Fabry disease.''; Biochim Biophys Acta, 2000 PubMed Europe PMC Scholia
  4. Yamaguchi K, Hata K, Koseki K, Shiozaki K, Akita H, Wada T, Moriya S, Miyagi T; ''Evidence for mitochondrial localization of a novel human sialidase (NEU4).''; Biochem J, 2005 PubMed Europe PMC Scholia
  5. Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU; ''Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  6. Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, Lloyd KO, Shiku H; ''Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  7. Honke K, Yamane M, Ishii A, Kobayashi T, Makita A; ''Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells.''; J Biochem, 1996 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
141861view11:55, 25 November 2025EweitzStandardize case
141860view11:54, 25 November 2025EweitzEconomize layout, align nodes
141859view11:48, 25 November 2025EweitzEconomize layout
141853view03:00, 25 November 2025EweitzAlign nodes
141852view02:57, 25 November 2025EweitzEconomize layout, align nodes
134482view01:09, 22 July 2024EweitzOntology Term : 'lipid metabolic pathway' added !
125119view10:00, 24 January 2023Conroy lipidsadd ECs
124465view20:09, 29 October 2022EgonwCompleted the LM identifier
124460view07:49, 29 October 2022EgonwUpdated the UniProt data sources
124453view08:41, 28 October 2022Conroy lipids
124452view08:38, 28 October 2022Conroy lipids
124451view08:25, 28 October 2022Conroy lipids
124444view15:39, 27 October 2022Conroy lipids
124443view15:19, 27 October 2022Conroy lipids
124442view15:16, 27 October 2022Conroy lipidsfix broken links
124441view15:15, 27 October 2022Conroy lipidsfix non-touching nodes
124440view15:12, 27 October 2022Conroy lipidsupdate layout, add some back-reactions
124398view15:38, 25 October 2022Conroy lipidsfix unconnections
124397view15:34, 25 October 2022Conroy lipidsOntology Term : 'sphingolipid biosynthetic pathway' added !
124396view15:34, 25 October 2022Conroy lipidsOntology Term : 'ganglioside metabolic pathway' added !
124395view15:30, 25 October 2022Conroy lipidsadded some more data. Need to clean up layout considerably
124393view11:19, 25 October 2022Conroy lipidsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
A3GALT2GeneProductU3KPV4 (Uniprot-SwissProt)
A4GALTGeneProductQ9NPC4 (Uniprot-TrEMBL)
ARSAGeneProductP15289 (Uniprot-TrEMBL)
B3GALT1GeneProductQ9Y5Z6 (Uniprot-TrEMBL)
B3GALT2GeneProductO43825 (Uniprot-TrEMBL)
B3GNT5GeneProductQ9BYG0 (Uniprot-TrEMBL)
B4GALNT1GeneProductQ00973 (Uniprot-TrEMBL)
B4GALT1GeneProductO60513 (Uniprot-TrEMBL)
B4GALT3GeneProductO60512 (Uniprot-TrEMBL)
B4GALT4GeneProductO60513 (Uniprot-TrEMBL)
B4GALT5GeneProductO43286 (Uniprot-TrEMBL)
B4GALT6GeneProductQ9UBX8 (Uniprot-TrEMBL)
CDGMetaboliteLMSP0509AA00 (LIPID MAPS)
CeramideMetaboliteLMSP02010000 (LIPID MAPS)
GA2MetaboliteLMSP0503AA00 (LIPID MAPS)
GAL3ST1GeneProductQ99999 (Uniprot-SwissProt)
GALCGeneProductP54803 (Uniprot-TrEMBL)
GBA1GeneProductP04062 (Uniprot-TrEMBL)
GBA2GeneProductQ9HCG7 (Uniprot-TrEMBL)
GBA3GeneProductQ9H227 (Uniprot-TrEMBL)
GLAGeneProductP06280 (Uniprot-TrEMBL)
GM3MetaboliteLMSP0601AJ00 (LIPID MAPS)
GM4MetaboliteLMSP0601AA00 (LIPID MAPS)
GalCerMetaboliteLMSP0501AC00 (LIPID MAPS)
Gala-SeriesPathway
Ganglio seriesPathway
Gb3MetaboliteMSP0502AA00 (LIPID MAPS)
GlcCerMetaboliteLMSP0501AA00 (LIPID MAPS)
Globo seriesPathway
LM1MetaboliteLMSP0504AB00 (LIPID MAPS)
LacCerMetaboliteLMSP0501AB00 (LIPID MAPS)
Lacto seriesPathway
Lc3CerMetaboliteLMSP0504AA00 (LIPID MAPS)
Neolacto seriesPathway
SM3MetaboliteLMSP0602AA00 (LIPID MAPS)
SM4MetaboliteLMSP0602AN00 (LIPID MAPS)
ST3GAL5GeneProductQ9UNP4 (Uniprot-TrEMBL)
UGCGGeneProductQ16739 (Uniprot-TrEMBL)
UGT8GeneProductQ16880 (Uniprot-TrEMBL)
iGb3MetaboliteLMSP0506AQ00 (LIPID MAPS)
isoGlobo seriesPathway
nLc4CerMetaboliteLMSP0505AA00 (LIPID MAPS)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
CeramideGalCermim-conversion13094 (Rhea)
CeramideGlcCermim-conversion12089 (Rhea)
GalCerCeramidemim-conversion14298 (Rhea)
GalCerGM4mim-conversion47601 (Rhea)
GalCerSM4mim-conversion20614 (Rhea)
GalCermim-conversion60061 (Rhea)
Gb3LacCermim-conversion21113 (Rhea)
GlcCerCeramidemim-conversion13270 (Rhea)
GlcCerLacCermim-conversion31496 (Rhea)
LacCerGA2mim-conversion47565 (Rhea)
LacCerGM3mim-conversion18418 (Rhea)
LacCerGb3mim-conversion11925 (Rhea)
LacCerLc3Cermim-conversion13906 (Rhea)
LacCerSM3mim-conversion41737 (Rhea)
LacCeriGb3mim-conversion42001 (Rhea)
Lc3CerLM1mim-conversion16046 (Rhea)
SM4GalCermim-conversion21301 (Rhea)
mim-conversion48061 (Rhea)
nLc4Cermim-conversion31500 (Rhea)
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