Synthesis of ceramides and 1-deoxyceramides (Homo sapiens)

From WikiPathways

Revision as of 14:25, 9 March 2022 by QuintenLok (Talk | contribs)
Jump to: navigation, search
Hexadecenalgloboside Gb3Cerganglioside GM4S1P lyaselactosylceramideSphingosineSphinganineA4GALTGlucosylceramideCERS1Lc3CersphingomyelinsKDSRSGMS1isogloboside iGb3CerDihydroceramideCerP(d18:1/16:0)Palmitoyl-CoAGalactosylceramideDESASAH1CERS2S1PDGAT1CERS4PhosphoethanolamineA3GALT2sphingosine-1-phosphateUGCGSPHK1CERKceramideB4GALNT1alanineserineSGMS2UGT8SPTLC11-O-acyl-ceramide3-ketosphinganineGA2B3GNT5sulphatideCERS321221112121-Deoxyceramide1-Deoxy-3-ketosphinganine221-deoxysphinganine1-Deoxysphingosine1-Deoxydihydroceramide22B4GALT13CERS5CERS6CERS4CERS1CERS2CERS3CERS5CERS6ASAH12


Description

synthesis of ceramides and 1-deoxyceramides from serine and alanine, respectively, including the synthesis of complex glycosphingolipids (Homo sapiens).

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

  1. Shayman JA; ''''; , PubMed Europe PMC Scholia
  2. Chatterjee S, Balram A, Li W; ''Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
  3. Sen P, Hyötyläinen T, Orešič M; ''1-Deoxyceramides - Key players in lipotoxicity and progression to type 2 diabetes?''; Acta Physiol (Oxf), 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134708view12:14, 26 July 2024EweitzModified description
134707view12:13, 26 July 2024EweitzModified description
134706view12:12, 26 July 2024EweitzUse singular
134705view12:11, 26 July 2024EweitzStandardize case
134704view12:09, 26 July 2024EweitzOmit species in pathway name in diagram, per convention
122165view14:04, 14 March 2022QuintenLokAdded pathway nodes
122158view12:07, 14 March 2022QuintenLokOntology Term : 'lacto-series glycosphingolipid metabolic pathway' added !
122157view12:06, 14 March 2022QuintenLokOntology Term : 'animal cell' added !
122156view12:02, 14 March 2022QuintenLokOntology Term : 'sphingolipid biosynthetic pathway' added !
122155view12:02, 14 March 2022QuintenLokOntology Term : 'ceramide signaling pathway' added !
122154view11:55, 14 March 2022QuintenLokAttempt to get the shayman reference to properly show up on wikipathways
122152view11:52, 14 March 2022QuintenLokFixed HMDB identifiers to match contemporary tags
122151view11:45, 14 March 2022QuintenLokMade the DGAT1 comment more descriptive
122145view11:41, 14 March 2022QuintenLokModified description
122144view11:38, 14 March 2022QuintenLokModified title
122143view11:38, 14 March 2022QuintenLokModified title
122126view14:21, 11 March 2022QuintenLokfixed layout and references
122108view00:27, 11 March 2022DeSlmade all Metabolite nodes blue
122067view14:25, 9 March 2022QuintenLokModified description
122066view14:23, 9 March 2022QuintenLokFixed remaining broken interaction terms
122065view14:16, 9 March 2022QuintenLokfixed 1 unatached interaction
121587view16:49, 21 February 2022QuintenLokAdded database identifiers for everything except deoxylipids, cant seem to find those
121442view13:46, 17 February 2022QuintenLoka lot more enzymes, more specificity
121433view12:53, 17 February 2022QuintenLokAdded a lot more specific enzymes and improved specificity of the glucosylceramide pathway
121361view12:36, 16 February 2022QuintenLokAdded a metabolite and an enzyme (+reference)
121359view11:44, 16 February 2022QuintenLokReverted to version '11:42, 16 February 2022' by QuintenLok
121358view11:43, 16 February 2022QuintenLok
121357view11:42, 16 February 2022QuintenLokNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-Deoxy-3-ketosphinganineMetaboliteCHEBI:17862 (ChEBI)
1-DeoxyceramideMetaboliteCHEBI:52639 (ChEBI)
1-DeoxydihydroceramideMetaboliteHMDB06752 (HMDB)
1-DeoxysphingosineMetaboliteHMDB00252 (HMDB)
1-O-acyl-ceramideMetaboliteCHEBI:133444 (ChEBI)
1-deoxysphinganineMetaboliteCHEBI:67109 (ChEBI)
3-ketosphinganineMetaboliteCHEBI:17862 (ChEBI)
A3GALT2GeneProductENSG00000184389 (Ensembl)
A4GALTGeneProductENSG00000128274 (Ensembl)
ASAH1GeneProductENSG00000104763 (Ensembl)
B3GNT5GeneProductENSG00000176597 (Ensembl)
B4GALNT1GeneProductENSG00000135454 (Ensembl)
B4GALT1GeneProductENSG00000086062 (Ensembl)
CERKGeneProductENSG00000100422 (Ensembl)
CERS1GeneProductENSG00000223802 (Ensembl)
CERS2GeneProductENSG00000143418 (Ensembl)
CERS3GeneProductENSG00000154227 (Ensembl)
CERS4GeneProductENSG00000090661 (Ensembl)
CERS5GeneProductENSG00000139624 (Ensembl)
CERS6GeneProductENSG00000172292 (Ensembl)
CerP(d18:1/16:0)MetaboliteCHEBI:72963 (ChEBI)
DESGeneProductENSG00000175084 (Ensembl)
DGAT1GeneProductENSG00000185000 (Ensembl)
  • Uncertain
  • Type your comment here
DihydroceramideMetaboliteHMDB06752 (HMDB)
GA2MetaboliteCHEBI:36774 (ChEBI)
GalactosylceramideMetaboliteCHEBI:18390 (ChEBI)
GlucosylceramideMetaboliteCHEBI:18368 (ChEBI)
HexadecenalMetaboliteHMDB60482 (HMDB)
KDSRGeneProductENSG00000119537 (Ensembl)
Lc3CerMetaboliteHMDB62485 (HMDB)
Palmitoyl-CoAMetaboliteCHEBI:15525 (ChEBI)
PhosphoethanolamineMetaboliteCHEBI:17553 (ChEBI)
S1P lyaseGeneProduct
S1PMetaboliteCHEBI:37550 (ChEBI)
SGMS1GeneProductENSG00000198964 (Ensembl)
SGMS2GeneProductENSG00000164023 (Ensembl)
SPHK1GeneProductENSG00000176170 (Ensembl)
SPTLC1ProteinO15269 (Uniprot-TrEMBL)
SphinganineMetaboliteHMDB00269 (HMDB)
SphingosineMetaboliteHMDB00252 (HMDB)
UGCGGeneProductENSG00000148154 (Ensembl)
UGT8GeneProductENSG00000174607 (Ensembl)
alanineMetaboliteCHEBI:16449 (ChEBI)
ceramideMetaboliteCHEBI:52639 (ChEBI)
ganglioside GM4MetaboliteCHEBI:27499 (ChEBI)
globoside Gb3CerMetaboliteCHEBI:88154 (ChEBI)
isogloboside iGb3CerMetaboliteCHEBI:140817 (ChEBI)
lactosylceramideMetaboliteCHEBI:134507 (ChEBI)
serineMetaboliteCHEBI:17822 (ChEBI)
sphingomyelinsMetaboliteCHEBI:62490 (ChEBI)
sphingosine-1-phosphateMetaboliteCHEBI:37550 (ChEBI)
sulphatideMetaboliteCHEBI:18318 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP5194"
Personal tools