Pleural mesothelioma (Homo sapiens)

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TCF7L1TCF714-3-314-3-39, 16112211, 221128, 3111121152172116738252562511, 1271125313925711294, 202526777662510251023, 39112525625625253325666257211611301318111818233183727373333137133113313133237331333133333231, 183713, 3332133313313371333332118331961331321337131321331833237TAMsMMChronic inflammation, proliferation, angiogenesis,resistance to apoptosispolycomb repressive complex 2 (PRC2)Collagenolysisa-cateninLegendPI3KPrognostic markersAMPKVDACIntegrinsMEKKCancer-associated fibroblastsGrowth arrestcytochrome cJNKsLAT1StabilizesTumorigenesis & ProliferationGene or protein IntegrinsMesothelial cellWNT pathwayRTKsTranscriptionDegradationHippo-Merlin signalingStiff and fibronectin rich ECMOther chemokines/cytokinesMAPK pathwayInflammatory cytokines,cellular stressesCell survivalInflammationCell growth,differentiationChemokines, Cytokines,Pro-angiogenic factorsAutophagyMDM2-P53 signalingChemokines/Cytokines etc.MetastasisAngiogenesisDNA methylationGenetic aberrationsCell survival & growthReplicative immortalityAP-1 dependent genes/Repair genesCadherinsCell growthIncreased protein synthesis+ Cell growthDNA-damageSLC2A1BMI1SUZ12VEGFACSF1ITGA1HGFEGFRRASSF1MYCCXCL12FGF2RAFACTBCSF2LGALS9PDGFRARASSF2RASSF5BRCA1Ca2+CTGFRASSF4TGFB1CER1CCL2CCL2SLC3A2PD-L1ITPR3RBBP4LAMA1TCA cycleWIF1CTGFHGFLIMD1glucoseSOSTRASSF6PLCB4DKK4IDO1MYCIGF1REEDBAG2PORCNIL10IGF1CCND1CTNNA1MCUSPARClet-7ITGB1LIN28BPHC1DKK1RASSF7MAPK8FGF2RING1VGLL4FGFR1KITLGDKK2BARD1CD44HBEGFFN1NOTUMFOXM1RNF2SERPINF1COL4A1EZH2FGF1RASSF3CYCSACTA2IL6LAMC1MDM4METBTCAREGKITTGFAACTA111261511, 22CDK4Histone modificationsP53BCL2CDKN2A8BAXRAGECyclinE14-3-3HIF1APIP3MCL1MMP9CDK7PDK1MAP3K5NF2RASNF-KBDNA repairMEK5GRB2TSC1CUL1ATMSTATSP1ROSMAPK14SHCSAV1ERK2LATS1ATG13JAKP21CDK2Cell cycleSETD2AngiogenesisULK223HMGB1c-fosMMP2MAP2K4E2FLATS25, 23PDGFGDPBTRCMAXKIBRACyclin DGABPAIL-1BFOXO1PUMAMST1ERK1EIF4c-junNLRP3P16INK4AVEGFFAKRHEBMDM2AJUBASETD5RPS6KA1MAP2K1MAP3K9PIGFfra-1TEAD1TSC2PIP2CASPASE-1AMOTRNSDR54E-BPSRCBAP123, 33PTENERK5MAP2K6TERT3, 35BECLIN1GTPBAKApoptosisULK1SETDB1MAD1BCLXLPRBp14ARFSOSSTATAP2CyclinD1FIP200RASMKNK1MAPKAPK2YAPTAZMDM2P21BAXCell transformationE2FPRBHMGB1HMGB1PRAS40TEL2TTI1MLST8DEPTORMTORHMGB1IL-1BPro IL-1BP21YAPTAZChemokines, Cytokines,Pro-angiogenic factorsCell survival33Wnt signalingAutophagyCell migrationNucleusNF-KBSRCNF25PAK1PAK2PAK3PAK4PAK5PAK62MAPK signaling pathwayMicroenvironment interactionsAngiogenesisVEGFBVEGFCVEGFD11TGFB1IL6PDGFAPDGFBPDGFCPDGFDMMP224MMP3MMP924MMP14EGF14FGFR2FGFR3FGFR42525IGF225METPDGFRB11COL4A2COL4A3COL4A411, 22COL4A5COL4A6LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3ITGA2ITGA3ITGA4ITGAVITGA6ITGB2ITGB3ITGB4LamininsFN111COL4A1COL4A2COL4A3COL4A411COL4A5COL4A6LAMA1LAMC1LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3CCL4CXCL10CXCL5CXCL12TGFB1VEGFAVEGFBVEGFCVEGFDglucoseSLC7A5ArginineArginineTryptophanTryptophanKynurenineTumor-associated macrophagesIL34PhagocytosisCXCL5CXCL12TGFB1T-LymphocytesCXCL5CXCL1IL6CXCL12CSF3PD-L1IL10Myeloid-Derived Suppressor Cellsprostaglandin E2CDH5CDH1CDH10CDH17CDH9CDH16CDH6CDH13CDH20CDH2CDH19CDH22CDH8CDH24CDH18CDH12CDH7CDH15CDH11CDH3CDH4PRKAB2PRKAB1PRKAA2PRKAG1PRKAA1PRKAG2PRKAG3FGFR2KDRINSRFGFR3IGF1RKITFGFR1EPHA2EGFRCSF1RFGFR4FLT1FLT4NGFRMETPDGFRAPDGFRBTEKFLT3NTRK1NTRK2RASMOB1AEFNA1FGF1FGF11FGF10EFNA2EGFFGF12CSF1ANGPT4ANGPT2ANGPT1VEGFAEFNA3EFNA4EFNA5FGF14FGF5FGF19FGF17FGF18FGF2FGF3FGF4FGF6FGF7FGF8FGF9VEGFDHGFIGF1IGF2INSKITLGFLT3LGVEGFCVEGFBPDGFBPGFPDGFANGFPDGFCFGF21FGF23FGF22PDGFDFGF20FGF13Growth FactorFGF19NTF3NTF4BDNFTGFAROSVEGFAVEGFBVEGFCVEGFDCCL512CD47ACTC1ACTG1ACTG2ITGB1ITGA1ITGA2ITGA3ITGA4ITGAVITGA6CTNNA2CTNNA3B1-integrinMOB1BTAZTEAD2TEAD3TEAD4STK32MAPK9MAPK10MAPK8MAPK9MAPK10JNKs2MINK1TNIKMAP4K1MAP4K2MAP4K4MAP4K3PSTK38LNDRG1FZD3FZD8FZD10FZD7FZD4FZD1FZD6FZD5FZD9FZD2SFRP1SFRP2SFRP4SFRP5SFRP1SFRP2SFRP4SFRP5Frizzled LigandsWNT3AWNT7AWNT11WNT1WNT5BWNT2WNT2BWNT6WNT5AWNT16WNT4WNT3WNT10BWNT7BWNT10AWNT16ROR1RYKROR2LRP5LRP6KREM16666FRAT1GSK3BCSNK2BAPCCSNK1ECTNNB1CSNK1A1CSNK2A1AXIN1CSNK1A1LCSNK2A3CSNK2A2CTNNB1PPFRAT2CXXC4SENP26DVL3DVL2DVL1DVL3DVL2DVL126S Proteasome DegradationCTNNB1PUbLEF1PPTCF7L2PPCTNNB16CHD8SOX176CTBP1CTBP2PLAU6CCND1JUNCCND3FOSL1MYCCCND2PIK3CAPIK3CBPIK3CDRPS6KB1RPS6KB2EIF4BRPS6PIK3CGAKT1AKT3AKT2PI3K-Akt signaling pathwayERK2JAK/STAT pathwayMAP2K2MAP2K7MAP2K31919MAP3K119MAP3K2MAP3K3MAP3K4MAP3K6ASKMAP3K10MAP3K11MLK19p38MEF2DATF2STAT1CREB1RPS6KA5ELK1MAXHMGN1DDIT3MKNK2MNKMAPKAPK2MKRPS6KA5MKNK1MKNK2MNKRPS6KA3RPS6KB1RPS6KB2RSKRPTOR15PRAS40TEL2TTI1MLST8DEPTORMTORRPTORMYC1515Frequently mutated tumor suppressor geneFrequently mutated oncogeneMetabolitePathwayCITTNNT1ADAMTS1MAD2L1UHRF1PRSS23KIF23PODXLTRAF2MDKSELECTHRC1DSC3Ca2+Endoplasmic reticulumCa2+CYCSpolycomb repressive complex 1 (PRC1)BARD1BRCA1


Description

Malignant Pleural Mesothelioma (MPM) is a rare type of cancer affecting the mesothelial cells of the lungs. 80% of the patients have been exposed to asbestos before being diagnosed, but only 5% of the people exposed to asbestos develop mesothelioma. Through a literature study, several pathways have been identified to contribute to the development of the disease, which are captured in this MPM pathway. Frequently mutated genes are highlighted in bold.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
140461view19:02, 26 August 2025KhanspersModified description
139849view08:41, 8 July 2025DdiglesDeleted hidden old description
139807view17:56, 6 July 2025EgonwMore unicode
137400view23:37, 1 March 2025EweitzModified description
137399view23:37, 1 March 2025EweitzOntology Term : 'malignant pleural mesothelioma' added !
137398view23:35, 1 March 2025EweitzOntology Term : 'mesothelial cell' added !
127398view20:36, 29 September 2023Khanspersupdated phospho sites
126829view09:08, 26 June 2023Marvin M2Modified description
126828view09:06, 26 June 2023Marvin M2Modified title
125314view21:41, 31 January 2023LarsgwAdd DOI to reference
124802view21:26, 11 December 2022AlexanderPicofixed citations
124785view06:42, 11 December 2022AlexanderPicofixed citations
122659view07:29, 27 April 2022Marvin M2Modified description
120373view20:34, 29 November 2021Marvin M2Connected line
120370view20:20, 29 November 2021Marvin M2Added comments for BAP1
120368view19:57, 29 November 2021Marvin M2Updated BAP1 section
120228view22:12, 15 November 2021Marvin M2Corrected PRC2 interactions
120227view22:05, 15 November 2021Marvin M2minor updates to BAP1 section
120212view21:31, 10 November 2021Marvin M2changed mutated genes view
120211view20:50, 10 November 2021Marvin M2Added HGNC symbols and ensembl IDs
120200view23:19, 8 November 2021ZiskaUpdated Ensembl IDs
120068view18:03, 26 October 2021Marvin M2Reshaped BAP1 section
119947view20:02, 27 September 2021Marvin M2Added list of biomarkers of prognosis
119931view20:20, 22 September 2021Marvin M2Legend added
119827view17:04, 29 August 2021Marvin M2Corrected mutated genes
119809view16:45, 26 August 2021Marvin M2Modified description
119808view15:53, 26 August 2021Marvin M2Added more detail and frequently mutated genes
119807view13:14, 26 August 2021Marvin M2Added MAPK target genes
119806view12:32, 26 August 2021Marvin M2Worked on MAPK pathway
119805view21:15, 25 August 2021Marvin M2Improved top left section
119804view20:04, 25 August 2021Marvin M2Improved, added frequently mutated genes.
119739view08:05, 11 August 2021L DupuisConnected lines
119730view12:29, 10 August 2021ZiskaExtended Wnt pathway
119729view19:44, 9 August 2021ZiskaAdded phosphorylation steps in Hippo signaling
119680view18:06, 28 July 2021EgonwFixed a reference
119679view18:04, 28 July 2021EgonwReplaced secondary ChEBI identifiers with primary ones.
119668view12:40, 28 July 2021Marvin M2Added JNKs
119667view12:22, 28 July 2021Marvin M2Cleaning hippo part
119666view12:11, 28 July 2021Marvin M2Improved hippo pathway part
119659view10:58, 28 July 2021Marvin M2Added content in microenvironment
119654view09:58, 28 July 2021Marvin M2Made space and added microenvironment parts
119642view00:10, 28 July 2021ZiskaExtended Hippo-Merlin signalling
119641view20:58, 27 July 2021Marvin M2Added secretions by mesothelioma
119640view20:12, 27 July 2021Marvin M2Added ECM content, and MMP regulations
119630view20:52, 23 July 2021Marvin M2Added ECM-linked hippo signaling, pathway nodes, and started miroenvironment interactions
119629view13:16, 23 July 2021ZiskaAdded regulation of TERT
119595view11:31, 21 July 2021Marvin M2improved annotations
119594view11:23, 21 July 2021Marvin M2Labels added
119586view08:54, 21 July 2021Marvin M2Red coloring for tumor suppressor genes
119580view15:41, 20 July 2021Marvin M2Minor graphical updates

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3ProteinA0A0J9YWE8 (Uniprot-TrEMBL)
26S Proteasome DegradationPathwayWP183 (WikiPathways)
4E-BPGeneProductENSG00000187840 (Ensembl)
ACTA1GeneProductENSG00000143632 (Ensembl)
ACTA2GeneProductENSG00000107796 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
ACTC1GeneProductENSG00000159251 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTG2GeneProductENSG00000163017 (Ensembl)
ADAMTS1GeneProductENSG00000154734 (Ensembl)
AJUBAGeneProductENSG00000129474 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
AMOTGeneProductENSG00000126016 (Ensembl)
ANGPT1GeneProductENSG00000154188 (Ensembl)
ANGPT2GeneProductENSG00000091879 (Ensembl)
ANGPT4GeneProductENSG00000101280 (Ensembl)
AP2GeneProductENSG00000170323 (Ensembl)
APCGeneProduct324 (Entrez Gene)
AREGGeneProductENSG00000109321 (Ensembl)
ATF2GeneProduct1386 (Entrez Gene)
ATG13GeneProductENSG00000175224 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
AngiogenesisPathwayWP1993 (WikiPathways)
ApoptosisPathwayWP1772 (WikiPathways)
ArginineMetaboliteCHEBI:29016 (ChEBI)
AutophagyPathwayWP4923 (WikiPathways)
BAG2GeneProductENSG00000112208 (Ensembl)
BAKGeneProductENSG00000030110 (Ensembl)
BAP1GeneProductENSG00000163930 (Ensembl)
BARD1GeneProductENSG00000138376 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCLXLGeneProductENSG00000171791 (Ensembl)
BDNFGeneProductENSG00000176697 (Ensembl)
BECLIN1GeneProductENSG00000126581 (Ensembl)
BMI1GeneProductENSG00000168283 (Ensembl)
BRCA1GeneProductENSG00000012048 (Ensembl)
BTCGeneProductENSG00000174808 (Ensembl)
BTRCGeneProductENSG00000166167 (Ensembl)
CASPASE-1GeneProductENSG00000137752 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCL4GeneProductENSG00000275302 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CCND1GeneProduct595 (Entrez Gene)
CCND1GeneProductENSG00000110092 (Ensembl)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CD44GeneProductENSG00000026508 (Ensembl)
CD47GeneProductENSG00000196776 (Ensembl)
CDH10GeneProduct1008 (Entrez Gene)
CDH11GeneProduct1009 (Entrez Gene)
CDH12GeneProduct1010 (Entrez Gene)
CDH13GeneProduct1012 (Entrez Gene)
CDH15GeneProduct1013 (Entrez Gene)
CDH16GeneProduct1014 (Entrez Gene)
CDH17GeneProduct1015 (Entrez Gene)
CDH18GeneProduct1016 (Entrez Gene)
CDH19GeneProduct28513 (Entrez Gene)
CDH1GeneProduct999 (Entrez Gene)
CDH20GeneProduct28316 (Entrez Gene)
CDH2GeneProduct1000 (Entrez Gene)
CDH22GeneProduct64405 (Entrez Gene)
CDH24GeneProduct64403 (Entrez Gene)
CDH3GeneProduct1001 (Entrez Gene)
CDH4GeneProduct1002 (Entrez Gene)
CDH5GeneProduct1003 (Entrez Gene)
CDH6GeneProduct1004 (Entrez Gene)
CDH7GeneProduct1005 (Entrez Gene)
CDH8GeneProduct1006 (Entrez Gene)
CDH9GeneProduct1007 (Entrez Gene)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK7GeneProductENSG00000134058 (Ensembl)
CDKN2AGeneProductCDKN2A (HGNC)
CER1GeneProductENSG00000147869 (Ensembl)
CHD8GeneProductENSG00000100888 (Ensembl)
CITGeneProductENSG00000122966 (Ensembl)
COL4A1GeneProductENSG00000187498 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
COL4A3GeneProductENSG00000169031 (Ensembl)
COL4A4GeneProductENSG00000081052 (Ensembl)
COL4A5GeneProductENSG00000188153 (Ensembl)
COL4A6GeneProductENSG00000197565 (Ensembl)
CREB1GeneProduct1385 (Entrez Gene)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF1RGeneProductENSG00000182578 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTGFGeneProductENSG00000118523 (Ensembl)
CTHRC1GeneProductENSG00000164932 (Ensembl)
CTNNA1GeneProductENSG00000044115 (Ensembl)
CTNNA2GeneProductENSG00000066032 (Ensembl)
CTNNA3GeneProductENSG00000183230 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CUL1GeneProductENSG00000055130 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL12GeneProduct6387 (Entrez Gene)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL5GeneProductENSG00000163735 (Ensembl)
CXXC4GeneProductENSG00000168772 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl) Cytochrome C
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cell cyclePathwayWP179 (WikiPathways)
Cell migrationPathwayWP4561 (WikiPathways)
Cyclin DGeneProductENSG00000110092 (Ensembl)
CyclinD1GeneProductENSG00000110092 (Ensembl)
CyclinEGeneProductENSG00000105173 (Ensembl)
DDIT3GeneProduct1649 (Entrez Gene)
DEPTORGeneProductENSG00000155792 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DKK2GeneProductENSG00000155011 (Ensembl)
DKK4GeneProductENSG00000104371 (Ensembl)
DNA repairPathwayWP4946 (WikiPathways)
DR5GeneProductENSG00000196363 (Ensembl)
DSC3GeneProductENSG00000134762 (Ensembl)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
E2FGeneProductENSG00000101412 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EFNA1GeneProductENSG00000169242 (Ensembl)
EFNA2GeneProductENSG00000099617 (Ensembl)
EFNA3GeneProductENSG00000143590 (Ensembl)
EFNA4GeneProductENSG00000243364 (Ensembl)
EFNA5GeneProductENSG00000184349 (Ensembl)
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4BGeneProductENSG00000063046 (Ensembl) Type your comment here
EIF4GeneProductENSG00000114867 (Ensembl)
ELK1GeneProduct2002 (Entrez Gene)
EPHA2GeneProductENSG00000142627 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
ERK5GeneProductENSG00000166484 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FGF10GeneProductENSG00000070193 (Ensembl)
FGF11GeneProductENSG00000161958 (Ensembl)
FGF12GeneProductENSG00000114279 (Ensembl)
FGF13GeneProductENSG00000129682 (Ensembl)
FGF14GeneProductENSG00000102466 (Ensembl)
FGF17GeneProductENSG00000158815 (Ensembl)
FGF18GeneProductENSG00000156427 (Ensembl)
FGF19GeneProductENSG00000162344 (Ensembl)
FGF1GeneProductENSG00000113578 (Ensembl)
FGF20GeneProductENSG00000078579 (Ensembl)
FGF21GeneProductENSG00000105550 (Ensembl)
FGF2GeneProduct2247 (Entrez Gene)
FGF22GeneProductENSG00000070388 (Ensembl)
FGF23GeneProductENSG00000118972 (Ensembl)
FGF2GeneProductENSG00000138685 (Ensembl)
FGF3GeneProductENSG00000186895 (Ensembl)
FGF4GeneProductENSG00000075388 (Ensembl)
FGF5GeneProductENSG00000138675 (Ensembl)
FGF6GeneProductENSG00000111241 (Ensembl)
FGF7GeneProductENSG00000140285 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FGF9GeneProductENSG00000102678 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
FGFR4GeneProductENSG00000160867 (Ensembl)
FIP200GeneProductENSG00000023287 (Ensembl)
FLT1GeneProductENSG00000102755 (Ensembl)
FLT3GeneProductENSG00000122025 (Ensembl)
FLT3LGGeneProductENSG00000090554 (Ensembl)
FLT4GeneProductENSG00000037280 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FOXM1GeneProductENSG00000111206 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
GABPAGeneProductENSG00000154727 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene)
GTPMetaboliteCHEBI:37565 (ChEBI)
HBEGFGeneProductENSG00000113070 (Ensembl)
HGFGeneProductENSG00000019991 (Ensembl)
HGFGeneProductHGF (HGNC)
HIF1AGeneProductENSG00000100644 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
HMGN1GeneProduct3150 (Entrez Gene)
Histone modificationsPathwayWP2369 (WikiPathways)
IDO1GeneProductENSG00000131203 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IGF1RGeneProductENSG00000140443 (Ensembl)
IGF2GeneProductENSG00000167244 (Ensembl)
IL-1BGeneProductENSG00000125538 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL34GeneProductENSG00000157368 (Ensembl)
IL6GeneProduct3569 (Entrez Gene)
IL6GeneProductENSG00000136244 (Ensembl)
INSGeneProductENSG00000254647 (Ensembl)
INSRGeneProductENSG00000171105 (Ensembl)
ITGA1GeneProductENSG00000213949 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGA3GeneProductENSG00000005884 (Ensembl)
ITGA4GeneProductENSG00000115232 (Ensembl)
ITGA6GeneProductENSG00000091409 (Ensembl)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
ITGB2GeneProductENSG00000160255 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITGB4GeneProductENSG00000132470 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
JAK/STAT pathwayPathwayWP2593 (WikiPathways)
JAKGeneProductENSG00000162434 (Ensembl)
JUNGeneProduct3725 (Entrez Gene)
KDRGeneProductENSG00000128052 (Ensembl)
KIBRAGeneProductENSG00000113645 (Ensembl)
KIF23GeneProductENSG00000137807 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
KITLGGeneProductENSG00000049130 (Ensembl)
KREM1GeneProduct83999 (Entrez Gene)
KynurenineMetaboliteCHEBI:28683 (ChEBI)
LAMA1GeneProductENSG00000101680 (Ensembl)
LAMA2GeneProductENSG00000196569 (Ensembl)
LAMA3GeneProductENSG00000053747 (Ensembl)
LAMA4GeneProductENSG00000112769 (Ensembl)
LAMA5GeneProductENSG00000130702 (Ensembl)
LAMB1GeneProductENSG00000091136 (Ensembl)
LAMB2GeneProductENSG00000172037 (Ensembl)
LAMB3GeneProductENSG00000196878 (Ensembl)
LAMC1GeneProductENSG00000135862 (Ensembl)
LAMC2GeneProductENSG00000058085 (Ensembl)
LAMC3GeneProductENSG00000050555 (Ensembl)
LATS1GeneProductENSG00000131023 (Ensembl)
LATS2GeneProductENSG00000150457 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
LGALS9GeneProductENSG00000168961 (Ensembl)
LIMD1GeneProductENSG00000144791 (Ensembl)
LIN28BGeneProductENSG00000187772 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
MAD1GeneProductENSG00000002822 (Ensembl)
MAD2L1GeneProductENSG00000164109 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP2K4GeneProductENSG00000065559 (Ensembl)
MAP2K6GeneProductENSG00000108984 (Ensembl)
MAP2K7GeneProductENSG00000076984 (Ensembl)
MAP3K10GeneProductENSG00000130758 (Ensembl)
MAP3K11GeneProductENSG00000173327 (Ensembl)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K2GeneProductENSG00000169967 (Ensembl)
MAP3K3GeneProductENSG00000198909 (Ensembl)
MAP3K4GeneProductENSG00000085511 (Ensembl)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MAP3K6GeneProductENSG00000142733 (Ensembl)
MAP3K9GeneProductENSG00000006432 (Ensembl)
MAP4K1GeneProductENSG00000104814 (Ensembl)
MAP4K2GeneProductENSG00000168067 (Ensembl)
MAP4K3GeneProductENSG00000011566 (Ensembl)
MAP4K4GeneProductENSG00000071054 (Ensembl)
MAPK signaling pathwayPathwayWP382 (WikiPathways)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAPKAPK2GeneProductENSG00000162889 (Ensembl)
MAXGeneProduct4149 (Entrez Gene)
MAXGeneProductENSG00000125952 (Ensembl)
MCL1GeneProductENSG00000143384 (Ensembl)
MCUGeneProductENSG00000156026 (Ensembl)
MDKGeneProductENSG00000110492 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MDM4GeneProductENSG00000198625 (Ensembl)
MEF2DGeneProduct4209 (Entrez Gene)
MEK5GeneProductENSG00000137764 (Ensembl)
METGeneProduct4233 (Entrez Gene)
METGeneProductENSG00000105976 (Ensembl)
MINK1GeneProductENSG00000141503 (Ensembl)
MKNK1GeneProductENSG00000079277 (Ensembl)
MKNK2GeneProductENSG00000099875 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MMP14GeneProductENSG00000157227 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MOB1AGeneProductENSG00000114978 (Ensembl)
MOB1BGeneProductENSG00000173542 (Ensembl)
MST1GeneProductENSG00000173531 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
MYCGeneProductENSG00000136997 (Ensembl)
NDRG1GeneProduct10397 (Entrez Gene) NDR1/2
NF-KBGeneProductENSG00000109320 (Ensembl)
NF2GeneProductENSG00000186575 (Ensembl)
NGFGeneProductENSG00000134259 (Ensembl)
NGFRGeneProductENSG00000064300 (Ensembl)
NLRP3GeneProductENSG00000162711 (Ensembl)
NOTUMGeneProductENSG00000185269 (Ensembl)
NTF3GeneProductENSG00000185652 (Ensembl)
NTF4GeneProductENSG00000225950 (Ensembl)
NTRK1GeneProductENSG00000198400 (Ensembl)
NTRK2GeneProductENSG00000148053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
P16INK4AGeneProductP42771 (Uniprot-TrEMBL)
P21GeneProductENSG00000124762 (Ensembl)
P53GeneProductENSG00000141510 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PAK2GeneProductENSG00000180370 (Ensembl)
PAK3GeneProductENSG00000077264 (Ensembl)
PAK4GeneProductENSG00000130669 (Ensembl)
PAK5GeneProductENSG00000101349 (Ensembl)
PAK6GeneProductPAK6 (HGNC)
PD-L1GeneProductENSG00000120217 (Ensembl)
PDGFAGeneProductENSG00000197461 (Ensembl)
PDGFAGeneProductPDGFA (HGNC)
PDGFBGeneProductENSG00000100311 (Ensembl)
PDGFBGeneProductPDGFB (HGNC)
PDGFCGeneProductENSG00000145431 (Ensembl)
PDGFCGeneProductPDGFC (HGNC)
PDGFDGeneProductENSG00000170962 (Ensembl)
PDGFDGeneProductPDGFD (HGNC)
PDGFGeneProductENSG00000197461 (Ensembl)
PDGFRAGeneProductENSG00000134853 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PGFGeneProductENSG00000119630 (Ensembl)
PHC1GeneProductENSG00000111752 (Ensembl)
PI3K-Akt signaling pathwayPathwayWP4172 (WikiPathways)
PIGFGeneProductENSG00000151665 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3CGGeneProductPIK3CG (HGNC)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLAUGeneProduct5328 (Entrez Gene)
PLCB4GeneProductENSG00000101333 (Ensembl)
PODXLGeneProductENSG00000128567 (Ensembl)
PORCNGeneProductENSG00000102312 (Ensembl)
PRAS40GeneProductENSG00000204673 (Ensembl)
PRBGeneProductENSG00000251655 (Ensembl)
PRKAA1GeneProduct5562 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRKAB1GeneProduct5564 (Entrez Gene)
PRKAB2GeneProduct5565 (Entrez Gene)
PRKAG1GeneProduct5571 (Entrez Gene)
PRKAG2GeneProduct51422 (Entrez Gene)
PRKAG3GeneProduct53632 (Entrez Gene)
PRSS23GeneProductENSG00000150687 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
PUMAGeneProductENSG00000105327 (Ensembl)
Pro IL-1BGeneProductENSG00000125538 (Ensembl)
RAFGeneProductENSG00000132155 (Ensembl)
RAGEGeneProductENSG00000204305 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RASSF1GeneProductENSG00000068028 (Ensembl)
RASSF2GeneProductENSG00000101265 (Ensembl)
RASSF3GeneProductENSG00000153179 (Ensembl)
RASSF4GeneProductENSG00000107551 (Ensembl)
RASSF5GeneProductENSG00000266094 (Ensembl)
RASSF6GeneProductENSG00000169435 (Ensembl)
RASSF7GeneProductENSG00000099849 (Ensembl)
RBBP4GeneProductENSG00000162521 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RING1GeneProductENSG00000204227 (Ensembl)
RNF2GeneProductENSG00000121481 (Ensembl)
RNSMetaboliteQ225595 (Wikidata)
ROR1GeneProduct4919 (Entrez Gene)
ROR2GeneProduct4920 (Entrez Gene)
ROSMetaboliteCHEBI:70982 (ChEBI)
RPS6GeneProductENSG00000137154 (Ensembl)
RPS6KA1GeneProductENSG00000117676 (Ensembl)
RPS6KA3GeneProductENSG00000177189 (Ensembl)
RPS6KA5GeneProduct9252 (Entrez Gene)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPS6KB2GeneProductENSG00000175634 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
RYKGeneProduct6259 (Entrez Gene)
SAV1GeneProductENSG00000151748 (Ensembl)
SELEGeneProductENSG00000007908 (Ensembl)
SENP2GeneProductENSG00000163904 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
SETD2GeneProductENSG00000181555 (Ensembl)
SETD5GeneProductENSG00000168137 (Ensembl)
SETDB1GeneProductENSG00000143379 (Ensembl)
SFRP1GeneProductENSG00000104332 (Ensembl)
SFRP2GeneProductENSG00000145423 (Ensembl)
SFRP4GeneProductENSG00000106483 (Ensembl)
SFRP5GeneProductENSG00000120057 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC3A2GeneProductENSG00000168003 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SPARCGeneProductENSG00000113140 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT1GeneProduct6772 (Entrez Gene)
STATGeneProductENSG00000115415 (Ensembl)
STK38LGeneProduct23012 (Entrez Gene) NDR1/2
STK3GeneProductENSG00000104375 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)
TAZGeneProduct25937 (Entrez Gene)
TCA cyclePathwayWP78 (WikiPathways) Also known as Krebs or citric acid cycle
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
TEAD1GeneProductENSG00000187079 (Ensembl)
TEAD2GeneProductENSG00000074219 (Ensembl)
TEAD3GeneProductENSG00000007866 (Ensembl)
TEAD4GeneProductENSG00000197905 (Ensembl)
TEKGeneProductENSG00000120156 (Ensembl)
TEL2GeneProductENSG00000100726 (Ensembl)
TERTGeneProductENSG00000164362 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TGFB1GeneProduct7040 (Entrez Gene)
TNIKGeneProductENSG00000154310 (Ensembl)
TNNT1GeneProductENSG00000105048 (Ensembl)
TRAF2GeneProductENSG00000127191 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TTI1GeneProductENSG00000101407 (Ensembl)
TryptophanMetaboliteCHEBI:16828 (ChEBI)
UHRF1GeneProductENSG00000276043 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
VEGFAGeneProduct7422 (Entrez Gene)
VEGFAGeneProductENSG00000112715 (Ensembl)
VEGFBGeneProductENSG00000173511 (Ensembl)
VEGFBGeneProductVEGFB (HGNC)
VEGFCGeneProductENSG00000150630 (Ensembl)
VEGFCGeneProductVEGFC (HGNC)
VEGFDGeneProductENSG00000165197 (Ensembl)
VEGFDGeneProductVEGFD (HGNC)
VEGFGeneProductENSG00000112715 (Ensembl)
VGLL4GeneProductENSG00000144560 (Ensembl)
WIF1GeneProductENSG00000156076 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
Wnt signalingPathwayWP428 (WikiPathways)
YAPGeneProductENSG00000137693 (Ensembl)
c-fosMetaboliteCHEBI:62519 (ChEBI)
c-junGeneProductENSG00000177606 (Ensembl)
fra-1 GeneProductENSG00000175592 (Ensembl)
glucoseMetaboliteCHEBI:17234 (ChEBI)
let-7RnaENSG00000284520 (Ensembl)
p14ARFProteinQ8N726 (Uniprot-TrEMBL)
prostaglandin E2MetaboliteCHEBI:15551 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP5087"