SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome (Homo sapiens)

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212111111111StimulationLegendSMC3SMC1A/SMC3 Role in DNA Damage Repair1, 2DSBRAD21SMC1ASMC3BRCA1NBNMRE11RAD50IRBRCA1RAD21SMC1ASMC3RAD21SMC1ASMC3NBNMRE11RAD50ATMATMATMBRCA1NBNMRE11RAD50RAD21SMC1ASMC3RAD21SMC1ASMC3ATMATMSMC1ASMC1ABRCA1NBNATMATMATMPAXIP1RAD18MDC1MDC1PAXIP11S Phase Arrest1RAD181InhibitionChromatid1RecruitmentIRIonizing RadiationDSBDouble Strand BreakSMC3ATM


Description

Role of cohesin subunits SMC1 and SMC3 during DNA damage response.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Yi F, Wang Z, Liu J, Zhang Y, Xu H, Li X, Bai N, Cao L, Song X; ''Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis.''; Int J Biol Sci, 2017 PubMed Europe PMC Scholia
  2. Litwin I, Pilarczyk E, Wysocki R; ''The Emerging Role of Cohesin in the DNA Damage Response.''; Genes (Basel), 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129308view13:49, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
125319view21:50, 31 January 2023LarsgwFix reference bp:ID
119397view10:49, 27 June 2021EweitzOntology Term : 'Cornelia de Lange syndrome' added !
119396view10:49, 27 June 2021EweitzModified title
119108view12:37, 17 June 2021IrkilmezANew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATMGeneProductENSG00000149311 (Ensembl) While SMC1A is specifically phosphorylated by phosphorylated ATM, no information was found on if the same applies to SMC3.
BRCA1GeneProductENSG00000012048 (Ensembl)
MDC1GeneProductENSG00000137337 (Ensembl)
MRE11GeneProductENSG00000020922 (Ensembl)
NBNGeneProductENSG00000104320 (Ensembl)
PAXIP1GeneProductENSG00000157212 (Ensembl)
RAD18GeneProductENSG00000070950 (Ensembl)
RAD21GeneProductENSG00000164754 (Ensembl)
RAD50GeneProductENSG00000113522 (Ensembl)
SMC1AGeneProductENSG00000072501 (Ensembl)
SMC3GeneProductENSG00000108055 (Ensembl)

Annotated Interactions

No annotated interactions

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