Prostaglandin and leukotriene metabolism in senescence (Homo sapiens)

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9999991015d-PGJ2PGG2p38 MAPKAdrenic acidRASTXA2PGD2IGFBP5EP2StressAdenylate CyclasePGE2InflammationCytosolic phospholipase A2COX-1GsArachidonic acidCytosolic phospholipase A2PTGDScAMPPLCPGI2PTGESp35Senescencedihomo-15d-PGJ2PGH2Membrane phospholipidsIL-6COX-2PGD SynthasePGE SynthasePGI SynthaseTxA SynthasePGF SynthasePGF2alphaEP1EP3 (extracellular)EP3 (intracellular)EP4G0GiGqAdenylate CyclasecAMPp35P4412, 56228, 10410121025, 10211925831105, 71111110SASPALOX5APCa2+ALOX5LTC4SLTA4HALOX15Bp21LTB45-HPETELTD4ROSp53Retinoblastoma proteinALOX15LTA4LTE4LTC4SIRT1ALOX12CysLT1Rp53PRetinoblastoma proteinPSenescenceCa2+


Description

Prostaglandin Metabolism in Senescence

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, Alimirah F, Castellanos CA, Ruan R, Wei Y, Chapman HA, Ramanathan A, Campisi J, Jourdan Le Saux C; ''Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis.''; JCI Insight, 2019 PubMed Europe PMC Scholia
  2. Menna C, Olivieri F, Catalano A, Procopio A; ''Lipoxygenase inhibitors for cancer prevention: promises and risks.''; Curr Pharm Des, 2010 PubMed Europe PMC Scholia
  3. Cormenier J, Martin N, Deslé J, Salazar-Cardozo C, Pourtier A, Abbadie C, Pluquet O; ''The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2intracrine pathway.''; Mech Ageing Dev, 2018 PubMed Europe PMC Scholia
  4. Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, Alimirah F, Kim DE, Payne T, Rosko A, Aimontche E, Deshpande SM, Neri F, Kuehnemann C, Demaria M, Ramanathan A, Campisi J; ''Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.''; Cell Metab, 2021 PubMed Europe PMC Scholia
  5. Häfner AK, Kahnt AS, Steinhilber D; ''Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase.''; Prostaglandins Other Lipid Mediat, 2019 PubMed Europe PMC Scholia
  6. Catalano A, Rodilossi S, Caprari P, Coppola V, Procopio A; ''5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation.''; EMBO J, 2005 PubMed Europe PMC Scholia
  7. Suryadevara V, Ramchandran R, Kamp DW, Natarajan V; ''Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  8. Lin Y, Xu Z; ''Fibroblast Senescence in Idiopathic Pulmonary Fibrosis.''; Front Cell Dev Biol, 2020 PubMed Europe PMC Scholia
  9. Yang HH, Kim C, Jung B, Kim KS, Kim JR; ''Involvement of IGF binding protein 5 in prostaglandin E(2)-induced cellular senescence in human fibroblasts.''; Biogerontology, 2011 PubMed Europe PMC Scholia
  10. Wei J, Chen S, Guo W, Feng B, Yang S, Huang C, Chu J; ''Leukotriene D4 induces cellular senescence in osteoblasts.''; Int Immunopharmacol, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139949view05:09, 13 July 2025EgonwCalcium ion with unicode
139766view13:26, 4 July 2025DdiglesDeleted hidden old description
139399view19:35, 13 June 2025Khanspersupdated description
139356view16:22, 5 June 2025Khanspersupdated description
138833view09:42, 4 May 2025EgonwMarked three datanodes with an Ensembl identifier as GeneProduct
138709view02:02, 30 April 2025EweitzTailor node dimensions
138708view00:50, 30 April 2025EweitzEconomize layout
138707view00:48, 30 April 2025EweitzAdd supplementary label to gene group
138698view12:34, 29 April 2025EweitzUpgrade "Stress" node, standardize colors
138697view12:29, 29 April 2025EweitzUse gene symbols
138696view12:10, 29 April 2025EweitzOntology Term : 'cellular senescence pathway' added !
138695view12:09, 29 April 2025EweitzUpgrade state labels
138694view12:04, 29 April 2025EweitzExpand acronym
138693view11:57, 29 April 2025EweitzEconomize layout, use gene symbols, standardize node color
138690view04:04, 29 April 2025EweitzUse gene symbols
138689view03:50, 29 April 2025EweitzEconomize layout
138688view03:46, 29 April 2025EweitzEconomize layout
138687view03:39, 29 April 2025EweitzEconomize layout
138686view03:34, 29 April 2025EweitzEconomize layout
138685view03:27, 29 April 2025EweitzUse gene symbols
138684view03:22, 29 April 2025EweitzEconomize layout
138683view03:13, 29 April 2025EweitzTailor node dimensions
119484view08:41, 2 July 2021EgonwUpdated data source so that link out work.
119438view07:46, 29 June 2021DKalbeDescription prostaglandins
119423view17:57, 28 June 2021JDoreenReferences
119416view12:11, 28 June 2021JDoreenAdded references and state
119412view09:59, 28 June 2021DKalbeChanging an arrow
119411view09:31, 28 June 2021JDoreenCorrections
119410view06:58, 28 June 2021DKalbeFixing interactions and description
119390view10:02, 27 June 2021JDoreenAnnotations
119380view12:00, 25 June 2021DKalbeDescription leukotrienes
119376view11:33, 25 June 2021TadeIdowuAnnotation
119374view10:46, 25 June 2021EweitzOntology Term : 'aging pathway' added !
119373view10:41, 25 June 2021EweitzOntology Term : 'leukotriene metabolic pathway' added !
119372view10:40, 25 June 2021EweitzOntology Term : 'prostaglandin metabolic pathway' added !
119369view10:34, 25 June 2021EweitzModified title
119354view19:28, 24 June 2021JDoreenAnnotations.
119353view14:14, 24 June 2021Aysegul CelikModified title
119343view10:05, 24 June 2021DKalbeData node
119342view09:56, 24 June 2021DKalbeData nodes
119341view09:49, 24 June 2021DKalbeData nodes
119340view09:33, 24 June 2021DKalbeData nodes
119339view09:17, 24 June 2021DKalbeReferences
119331view15:48, 23 June 2021JDoreenAnnotations
119326view15:14, 23 June 2021JDoreenArrows and boxes.
119322view14:43, 23 June 2021JDoreenModified description
119321view14:28, 23 June 2021JDoreenp53 and ROS.
119320view13:47, 23 June 2021JDoreenChanged anchoring of some arrows and some boxes. Added shape to pathways.
119302view13:03, 23 June 2021Frucsek13Modified title
119299view11:45, 23 June 2021TadeIdowuP38 MAPK

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15d-PGJ2MetaboliteCHEBI:34159 (ChEBI)
5-HPETEMetaboliteHMDB11135 (HMDB)
ALOX12GeneProductENSG00000108839 (Ensembl)
ALOX15BGeneProductENSG00000179593 (Ensembl)
ALOX15GeneProductENSG00000161905 (Ensembl)
ALOX5APGeneProductENSG00000132965 (Ensembl)
ALOX5GeneProductENSG00000012779 (Ensembl)
Adenylate CyclaseProteinA0A0A0MSC1 (Uniprot-TrEMBL)
Adrenic acidMetaboliteCHEBI:53487 (ChEBI)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
COX-1GeneProductENSG00000095303 (Ensembl)
COX-2GeneProductENSG00000073756 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CysLT1RProteinQ9Y271 (Uniprot-TrEMBL)
Cytosolic phospholipase A2ProteinP47712 (Uniprot-TrEMBL)
EP1
EP2
EP3 (extracellular)
EP3 (intracellular)
EP4
G0Protein
GiProtein
GqProtein
GsProtein
IGFBP5GeneProductENSG00000115461 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
Inflammation
LTA4MetaboliteCHEBI:15651 (ChEBI)
LTA4HGeneProductENSG00000111144 (Ensembl)
LTB4MetaboliteCHEBI:15647 (ChEBI)
LTC4MetaboliteCHEBI:16978 (ChEBI)
LTC4SGeneProductENSG00000213316 (Ensembl)
LTD4MetaboliteCHEBI:28666 (ChEBI)
LTE4MetaboliteCHEBI:15650 (ChEBI)
Membrane phospholipidsMetaboliteCHEBI:16247 (ChEBI)
PGD Synthase
PGD2MetaboliteCHEBI:15555 (ChEBI)
PGE Synthase
PGE2MetaboliteCHEBI:15551 (ChEBI)
PGF Synthase
PGF2alphaMetaboliteCHEBI:15553 (ChEBI)
PGG2MetaboliteCHEBI:27647 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
PGI Synthase
PGI2MetaboliteCHEBI:15552 (ChEBI)
PLC
PTGDSGeneProductENSG00000107317 (Ensembl)
PTGESGeneProductENSG00000148344 (Ensembl)
RASProteinP01112 (Uniprot-TrEMBL)
ROSPathway
Retinoblastoma proteinGeneProduct
SIRT1GeneProductENSG00000096717 (Ensembl)
SenescencePathway
StressGeneProduct
TXA2MetaboliteCHEBI:15627 (ChEBI)
TxA Synthase
cAMPMetaboliteHMDB00058 (HMDB)
dihomo-15d-PGJ2Metabolite
p21ProteinA0A024RCX5 (Uniprot-TrEMBL)
p35
p38 MAPKGeneProductENSG00000185386 (Ensembl)
p53MetaboliteCHEBI:77731 (ChEBI)

Annotated Interactions

No annotated interactions

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