Hepatocyte growth factor receptor signaling (Homo sapiens)

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11TrancriptionAKT PathwayTranscriptionof Cox2CytoplasmRAC1pathwayChanges in Cytoskeletonand Cell mobilityActinRight Click for CommentsAP-1ExtracellularTranscriptionAnoikisRHOpathwayCDC42pathwayFOSPTPN11ELK1MAP4K1PXNPMAPK1PIK3CAPAK1GRB2PXNMAPK8MetPTK2BJUNSRCRAP1BCRKLGAB1SRCHRASSTAT3CRKPTENMAP2K2RAF1PTK2RAPGEF1RASA1pMAPK3RAP1AMAP2K1ITGB1PTK2pDOCK1HGFPTK2BITGA1SOS1


Description

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Ontology Terms

 

Bibliography

  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142000view12:54, 29 November 2025EweitzUse transcription interaction
141994view12:53, 29 November 2025EweitzUse gene symbol
141990view12:49, 29 November 2025EweitzLabel cell type
141989view12:48, 29 November 2025EweitzUpgrade cell model
141988view12:45, 29 November 2025EweitzUse gene symbol
137100view22:52, 27 February 2025KhanspersModified description
135132view21:15, 6 August 2024EweitzFix typo, standardize state, case
135131view12:51, 6 August 2024EweitzEconomize layout
118735view10:49, 1 June 2021DeSlRemoved Textlabel
118651view15:05, 31 May 2021DeSlConverted textlabel "P" to States
118645view14:58, 31 May 2021DeSlUpdated ReceptorSquare to binding in correct direction with lit. ref
116706view09:17, 11 May 2021EweitzModified title
116705view09:14, 11 May 2021EweitzModified title
107452view17:09, 10 October 2019Khanspersremoved genmapp comment
107451view17:09, 10 October 2019KhanspersModified description
105816view23:00, 15 August 2019KhanspersModified description
97740view13:02, 7 June 2018RoelodAdded reference
97738view13:01, 7 June 2018RoelodModified description
97735view12:59, 7 June 2018RoelodModified description
97731view12:55, 7 June 2018RoelodModified description
79946view10:02, 28 April 2015ZariChanged RAT ID to human ID for Met gene
71094view14:05, 4 October 2013Mkutmonconnected lines
69027view17:49, 8 July 2013MaintBotUpdated to 2013 gpml schema
45129view00:16, 7 October 2011KhanspersOntology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
45128view00:15, 7 October 2011KhanspersOntology Term : 'hepatocyte' added !
45127view00:15, 7 October 2011KhanspersOntology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
41206view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
38851view17:56, 24 September 2010Khanspers
32395view17:00, 15 August 2009MaintBotFixed text labels
32043view13:29, 14 August 2009MaintBotFixed group labels
21339view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Signaling of Hepatocyte Growth Factor Receptor Biocarta]] moved to [[Pathway:WP313]]: Moved to stable identifier
14928view15:19, 24 May 2008MartijnVanIersellinked up
12922view10:40, 17 May 2008MaintBotSticky edges patch by Sjoerd
8384view13:46, 7 January 2008MaintBot[[Pathway:Human:Signaling of Hepatocyte Growth Factor Receptor Biocarta]] moved to [[Pathway:Homo sapiens:Signaling of Hepatocyte Growth Factor Receptor Biocarta]]: Renaming species
7809view16:19, 18 December 2007MaintBotfixed category names
7295view12:41, 4 November 2007MaintBotAdded categories to GPML
6389view22:18, 22 May 2007169.230.77.174gpml file for [[Human:Signaling_of_Hepatocyte_Growth_Factor_Receptor_Biocarta]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
DOCK1GeneProduct1793 (Entrez Gene) Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
ELK1GeneProduct2002 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
HGFGeneProduct3082 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
ITGA1GeneProduct3672 (Entrez Gene)
ITGB1GeneProduct3688 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MetGeneProduct4233 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PTENGeneProduct5728 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene)
RAP1BGeneProduct5908 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene) Son of sevenless homolog 1 (Drosophila) (predicted)
SRCGeneProduct6714 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP313"
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