DNA replication (Caenorhabditis elegans)

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dATPp70Mcm6OriginATPOrc complexp49PCNA homotrimerMcm4Phosphorylated Cdc6RNA primer-DNA primer:origin duplex:PCNAUbiquitinMcm5Orc3Mcm4GemininOrc ComplexRFC Heteropentamer:RNA primer-DNA primerATP1. Assembly of the pre-replicative complexOrc3DNA polymerase alpha: primase: origin complexUTPDNA polymerase alpha: primase: origin complexRFC Heteropentamer:RNA primer-DNA primer:Orc complexOrc2Mcm7Pre-replicative complexUbiquitinated Cdc6dUTPdCTP5. Leading/lagging strand synthesisADPCdc6Mcm3GTPMcm7Orc2p180RFC36Ubiquitinated Orc1ADPwith the replication forkOrc5CTPUbiquitinPhosphorylated Orc1Orc3Mcm2RFC140Orc5RNA primer-DNA primerDNA PolymeraseOrc complexDegraded by proteasome in cytosoldGTPRFC37Processive complexOrc2Cdt1Orc5Mcm10Orc complex4. Switching of origins to post-replicative state2. Activation of the pre-replicative complexMcm3Pre-replicative complexATPCdt1RNA primer-DNA primerOrc3Orc4Cdc6Cdt1Mcm 4,6,7 trimer forms and associatesCdt1Mcm5Mcm2Degraded by proteasome in cytosolPhosphorylation of Mcm 2-7 complexPrimaseCdc6aRFC40ATPRFC38p58Cdc63. DNA replication initiationOrc1RNA PrimerMcm6Orc2Cdt1Orc4RPA3mcm-7POLD3RPA4ubq-2ORC4LRPA2POLD4ASKcdc-6F33H2.5PCNAY47D3A.28Y47D3A.29orc-2CDT1ORC3Lrfc-3rfc-2POLD2Y39A1A.12CDC7mcm-3mcm-4div-1ubq-1CDK2mcm-6GMNNmcm-2RFC4CDC46pri-1F08B4.5F34D10.2ORC5Lrfc-1pri-2ORC6LARPAF10C2.4RPA1


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
139039view19:30, 12 May 2025KhanspersModified description
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
ATPMetaboliteCHEBI:15422 (ChEBI)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
CTPMetaboliteCHEBI:17677 (ChEBI)
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
GTPMetaboliteCHEBI:15996 (ChEBI)
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
UTPMetaboliteCHEBI:15713 (ChEBI)
UbiquitinProtein
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
dATPMetaboliteCHEBI:16284 (ChEBI)
dCTPMetaboliteCHEBI:16311 (ChEBI)
dGTPMetaboliteCHEBI:16497 (ChEBI)
dUTPMetaboliteCHEBI:17625 (ChEBI)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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