Iron homeostasis (Mus musculus)

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Oxidative StressBloodInflammationCellTrfr1TransferrincMycBMPR-1SMAD-1/5/8IL1RTnfSTAT3FerroportinTrfr2hemojuvelinIL-6IronFth1Ftl1hepcidinBMP1/2/4/9hepcidin-2IL-1IL6RhepcidinIreb2JAK1/2hepcidin-2HfeIron


Description

Iron is nessisary for all mammalian cells but is also toxic in excess. This pathway shows the regulation of iron between a cell and the blood stream.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
142309view10:53, 1 January 2026Egonwmim-translocation
126400view15:38, 26 April 2023EgonwLicense is CCZero
117909view10:32, 23 May 2021EweitzModified title
106857view13:33, 17 September 2019MaintBotHMDB identifier normalization
72018view12:38, 24 October 2013Mkutmonfixed unconnected lines
71718view20:15, 17 October 2013MaintBotAutomated update of data sources
67413view10:58, 26 June 2013DdiglesOntology Term : 'iron homeostasis pathway' added !
60840view11:45, 29 March 2013EgonwFixed two iron metabolites which were annotated as GeneProduct.
59023view20:40, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
43784view20:54, 27 July 2011Samuel SklarModified description
43783view20:45, 27 July 2011Samuel SklarSpecify description
41260view00:20, 2 March 2011MaintBotRemoved redundant pathway information and comments
38148view19:14, 17 August 2010KhanspersModified categories
38130view11:02, 16 August 2010MartijnVanIerselNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BMP1/2/4/9GeneProduct
BMPR-1GeneProduct
FerroportinGeneProductENSMUSG00000025993 (Ensembl)
Fth1GeneProduct14319 (Entrez Gene)
Ftl1GeneProductENSMUSG00000050708 (Ensembl)
HfeGeneProductENSMUSG00000006611 (Ensembl)
IL-1GeneProductENSMUSG00000027399 (Ensembl)
IL-6GeneProductENSMUSG00000025746 (Ensembl)
IL1RGeneProduct
IL6RGeneProductENSMUSG00000027947 (Ensembl)
Ireb2GeneProductENSMUSG00000032293 (Ensembl)
IronMetaboliteHMDB0000692 (HMDB)
JAK1/2GeneProduct
SMAD-1/5/8GeneProduct
STAT3GeneProduct
TnfGeneProductENSMUSG00000024401 (Ensembl)
TransferrinGeneProductENSMUSG00000032554 (Ensembl)
Trfr1GeneProduct
Trfr2GeneProductENSMUSG00000029716 (Ensembl)
cMycGeneProduct
hemojuvelinGeneProductENSMUSG00000038403 (Ensembl)
hepcidin-2GeneProductENSMUSG00000056978 (Ensembl)
hepcidinGeneProductENSMUSG00000050440 (Ensembl)

Annotated Interactions

No annotated interactions

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