Statin pathway (Bos taurus)

From WikiPathways

Revision as of 11:39, 21 May 2021 by Eweitz (Talk | contribs)
Jump to: navigation, search
12Liver cellPlasmaPeripheral tissuesEnterocyteActivationLRP1Acetyl-CoAPDIA2SOAT1ACSS1CETPAPOC1StatinPLTPCholesterol esterLIPCCholesterolbta-mir-33aCholic AcidLDLLipoproteinsAPOC3APOBAcyl-CoACYP7A1DGAT1TriglycerideABCG5ABCA1IDLAPOA2MTTPCholesterolAPOC2DAGLDLRAPOA1SQLEMevalonateHMGCRHDLCholesterolPhospholipidVLDLABCA1bta-mir-33bAPOA4CholesterolLPLFatty acidAPOA5ABCG8SqualeneFDFT1SCARB1LCATAPOEInhibitionTransportCatalysis


Description

Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism.

Sources: PharmGKB and Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP430(78268) with a 90.0% conversion rate.

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia
  2. Wetterau JR, Lin MC, Jamil H; ''Microsomal triglyceride transfer protein.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141295view09:06, 8 November 2025EgonwModified description
137509view18:55, 3 March 2025KhanspersModified description
129529view01:24, 9 May 2024EweitzOntology Term : '' added !
117611view11:39, 21 May 2021EweitzModified title
106004view11:53, 16 August 2019MaintBotHMDB identifier normalization
103263view07:46, 20 February 2019EgonwMore specific ChEBI identifier.
82697view18:42, 22 October 2015EgonwMore specific ChEBI identifiers.
80853view15:28, 30 June 2015Mkutmonhomology conversion
71420view19:02, 17 October 2013MaintBotAutomated update of data sources
67658view11:45, 26 June 2013DdiglesOntology Term : 'statin drug pathway' added !
63383view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
40555view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
38712view19:31, 23 September 2010AlexanderPico
35546view14:20, 12 February 2010Thomasadded literature, cosmetic change
33794view00:14, 9 December 2009MaintBotAutomatic update of empty xrefs
31678view11:43, 14 August 2009MaintBotFixed group labels
30610view22:18, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCA1GeneProductENSBTAG00000020661 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19
ABCG5GeneProductENSBTAG00000016365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240
ABCG8GeneProductENSBTAG00000016366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241
ACSS1ProteinENSBTAG00000004281 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84532
APOA1GeneProductENSBTAG00000002258 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:335
APOA2GeneProductENSBTAG00000009212 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:336
APOA4GeneProductENSBTAG00000019770 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:337
APOA5GeneProductENSBTAG00000019764 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:116519
APOBGeneProductENSBTAG00000008505 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:338
APOC1GeneProduct
APOC2GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000020558;En:ENSBTAG00000020558;
APOC3GeneProductENSBTAG00000012398 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:345
APOEGeneProductENSBTAG00000010123 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:348
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
Acyl-CoAMetaboliteHMDB0003419 (HMDB)
CETPGeneProduct
CYP7A1GeneProductENSBTAG00000005287 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
Cholesterol esterMetaboliteC02530 (KEGG Compound)
CholesterolMetabolite57-88-5 (CAS)
Cholic AcidMetabolite81-25-4 (CAS)
DAGMetaboliteC00165 (KEGG Compound)
DGAT1GeneProductENSBTAG00000026356 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8694
FDFT1GeneProductENSBTAG00000012432 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222
Fatty acidMetaboliteC00162 (KEGG Compound)
HDLMetaboliteCHEBI:39025 (ChEBI)
HMGCRGeneProductENSBTAG00000007840 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156
IDLMetaboliteC01834 (KEGG Compound)
LCATGeneProductENSBTAG00000018043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3931
LDLMetaboliteCHEBI:39026 (ChEBI)
LDLRGeneProductENSBTAG00000012314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
LIPCGeneProductENSBTAG00000005479 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3990
LPLGeneProductENSBTAG00000012855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023
LRP1GeneProductENSBTAG00000010830 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4035
LipoproteinsMetaboliteCHEBI:6495 (ChEBI)
MTTPProteinENSBTAG00000011944 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4547
MevalonateMetaboliteCHEBI:25350 (ChEBI)
PDIA2ProteinENSBTAG00000016575 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64714
PLTPGeneProductENSBTAG00000000559 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5360
PhospholipidMetaboliteC00865 (KEGG Compound)
SCARB1GeneProductENSBTAG00000014269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949
SOAT1GeneProductENSBTAG00000004059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6646
SQLEGeneProductENSBTAG00000005498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713
SqualeneMetaboliteHMDB0000256 (HMDB)
StatinMetaboliteCHEBI:87631 (ChEBI)
TriglycerideMetaboliteC00422 (KEGG Compound)
VLDLMetaboliteCHEBI:39027 (ChEBI)
bta-mir-33aGeneProductENSBTAG00000029975 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932
bta-mir-33bGeneProductENSBTAG00000036437 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839

Annotated Interactions

No annotated interactions
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP1041"
Personal tools