Angiotensin II receptor type 1 pathway (Homo sapiens)

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3, 4, 6, 7, 9...1, 3, 4, 6, 7, 9...myofibroblast transition2, 5, 7FibrosisInflammatory cytokinesCytokine stormpro-oxidantlung vascular smooth muscle cellIntrinsic coagulation pathwayContractionJNKlung fibroblastAlveolar Epithelial Cellbasic-FGF, PDGF-sIL2TGFBR1ANG 1-7NOX4IL-8MKKMAPK1MAS1MMP3CSF3CCL2CSF2ROSTGFBR2CXCL10RACK1TNF alphaACE2RasIL-12RAFNF-kappa-B AngiotensinogenIL-1 BetaPathwayMMP1IL-6SMAD4PDGFDIL11RAACTA2SP1AGTR1SMAD3JUNDInterleukin-11 Signaling PathwayIL11angiotensin IICTGFF12HIF1A8ApoptosisTGFB1Cell CycleProtein Kinase CIL6STPTPN11COL1A1Complement and Coagulation CascadesAGTR1AGTR1COL1A2TGFB1IL11prostaglandins, VEGFCOL1A1COL1A2angiotensin IIangiotensin IITGFB1RAS / NRASSMAD3PAngiotensinogenMAPK1PNOX4NF-kappa-B Inflammatory cytokinesCOL1A1COL1A1FibrosisROSRasRAFMKKMAPK1MAPK1PTGFB1TGFBR1TGFBR2SMAD3SMAD4SMAD3PIL-8MMP3CCL2TNF alphaIL-12IL-1 BetaMMP1IL-6IL-6IL-1 BetaIL-8CCL2TNF alphaIL-12IL2CSF3CSF2CXCL10IL-6IL-1 BetaIL-8CCL2TNF alphaIL-12Cytokine storm


Description

First setup of pathway. Needs exploration of the links to collagen synthesis, and the link to cell cycle / mitosis. KEGG pathway 05171 was referenced for the pathway development.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. López-Bergami P, Habelhah H, Bhoumik A, Zhang W, Wang LH, Ronai Z; ''RACK1 mediates activation of JNK by protein kinase C [corrected].''; Mol Cell, 2005 PubMed Europe PMC Scholia
  2. Ford CM, Li S, Pickering JG; ''Angiotensin II stimulates collagen synthesis in human vascular smooth muscle cells. Involvement of the AT(1) receptor, transforming growth factor-beta, and tyrosine phosphorylation.''; Arterioscler Thromb Vasc Biol, 1999 PubMed Europe PMC Scholia
  3. van der Meijden PE, Munnix IC, Auger JM, Govers-Riemslag JW, Cosemans JM, Kuijpers MJ, Spronk HM, Watson SP, Renné T, Heemskerk JW; ''Dual role of collagen in factor XII-dependent thrombus formation.''; Blood, 2009 PubMed Europe PMC Scholia
  4. Zhang K, Phan SH; ''Cytokines and pulmonary fibrosis.''; Biol Signals, 1996 PubMed Europe PMC Scholia
  5. Chappell MC; ''Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure?''; Hypertension, 2007 PubMed Europe PMC Scholia
  6. Uhal BD, Li X, Piasecki CC, Molina-Molina M; ''Angiotensin signalling in pulmonary fibrosis.''; Int J Biochem Cell Biol, 2012 PubMed Europe PMC Scholia
  7. Ng B, Cook SA, Schafer S; ''Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway.''; Exp Mol Med, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139761view12:16, 4 July 2025DdiglesDeleted hidden old descriptions
128622view01:17, 17 February 2024EweitzUpgrade disease nodes, refinement alignments, economize layout
128621view01:06, 17 February 2024EweitzEconomize layout
128620view00:49, 17 February 2024EweitzRefine legend, economize layout
128619view00:33, 17 February 2024EweitzEconomize layout
128618view00:22, 17 February 2024EweitzEconomize layout
128614view00:02, 17 February 2024EweitzEconomize layout
128613view23:38, 16 February 2024EweitzStandardize case
128585view23:26, 14 February 2024EweitzOntology Term : 'epithelial cell' added !
128584view23:25, 14 February 2024EweitzOntology Term : 'smooth muscle cell' added !
128583view23:24, 14 February 2024EweitzOntology Term : 'vascular associated smooth muscle cell' added !
128582view23:24, 14 February 2024EweitzOntology Term : 'fibroblast of lung' added !
125920view05:57, 20 March 2023EgonwNot a mim-conversion
125625view20:09, 5 March 2023AlexanderPicoModified description
125259view11:43, 31 January 2023EgonwRemoved two more duplicate references
125258view11:41, 31 January 2023EgonwRemoved duplicate references and fixed character encoding issues
119016view18:50, 9 June 2021EgonwNot a mim-conversion
118782view18:31, 1 June 2021RaatsSlegend changes
118202view08:00, 26 May 2021RaatsSID fix and legend addition
117648view11:42, 22 May 2021EweitzModified title
116387view12:55, 6 May 2021RaatsSfixed unclickable pathway
116386view12:54, 6 May 2021RaatsSfixed unclickable pathway link
116385view11:23, 6 May 2021RaatsSReplaced nodes with a new pathway.
116324view12:36, 30 April 2021Marvin M2double datanode pathway removed
116323view12:24, 30 April 2021Marvin M2minor edits, WP IDs fixed
116272view11:22, 23 April 2021RaatsSModified description
116271view11:17, 23 April 2021RaatsSExpanded and elaborated the pathway
115405view21:28, 17 February 2021KhanspersOntology Term : 'angiotensin II signaling pathway' added !
115404view21:28, 17 February 2021KhanspersOntology Term : 'signaling pathway' added !
114331view10:31, 8 January 2021Marvin M2small graphical update
114330view11:21, 7 January 2021Marvin M2Added pathway link for coagulation
114329view11:18, 7 January 2021Marvin M2Updated layout, added link to coagulation
114328view10:58, 7 January 2021Marvin M2rounded rectangles for pathways
114327view10:57, 7 January 2021Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE2ProteinQ9BYF1 (Uniprot-TrEMBL)
ACTA2GeneProductENSG00000107796 (Ensembl)
AGTR1GeneProductENSG00000144891 (Ensembl)
ANG 1-7Metabolite
AngiotensinogenProteinP01019 (Uniprot-TrEMBL)
ApoptosisPathwayWP254 (WikiPathways)
CCL2GeneProduct6347 (Entrez Gene)
COL1A1GeneProductENSG00000108821 (Ensembl)
COL1A2GeneProductENSG00000164692 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CTGFGeneProductENSG00000118523 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
Cell CyclePathwayWP179 (WikiPathways)
Complement and Coagulation CascadesPathwayWP558 (WikiPathways)
F12GeneProductENSG00000131187 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
IL-1 BetaGeneProductENSG00000125538 (Ensembl)
IL-12GeneProductIL12A (HGNC)
IL-6GeneProductENSG00000136244 (Ensembl)
IL-8GeneProductENSG00000169429 (Ensembl)
IL11GeneProductENSG00000095752 (Ensembl)
IL11RAGeneProductENSG00000137070 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL6STGeneProductENSG00000134352 (Ensembl)
Interleukin-11 Signaling PathwayPathwayWP2332 (WikiPathways)
JUNDGeneProductENSG00000130522 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAS1GeneProductENSG00000130368 (Ensembl)
MKKGeneProductENSG00000108984 (Ensembl)
MMP1GeneProductENSG00000196611 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
NF-kappa-B ProteinD6RC45 (Uniprot-TrEMBL)
NOX4GeneProduct50507 (Entrez Gene)
PDGFDGeneProductENSG00000170962 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
PathwayPathway
Protein Kinase CComplex2.7.11.13 (Enzyme Nomenclature)
RACK1GeneProductENSG00000204628 (Ensembl)
RAFGeneProductENSG00000132155 (Ensembl)
RAS / NRASPathwayWP4818 (WikiPathways)
ROSMetaboliteCHEBI:26523 (ChEBI)
RasGeneProductENSG00000126458 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TNF alphaGeneProductENSG00000232810 (Ensembl)
angiotensin IIMetaboliteCHEBI:58506 (ChEBI)

Annotated Interactions

No annotated interactions

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