Vitamin E (Homo sapiens)

From WikiPathways

Revision as of 11:38, 2 November 2020 by ReactomeTeam (Talk | contribs)
Jump to: navigation, search
3, 61-3, 5, 61-6cytosollysosomal lumenTTPA TTPA:alpha-TOHalpha-TOHTTPA:alpha-TOHTTPA alpha-TOH TTPAalpha-TOH


Description

Vitamins A, D, E and K are lipophilic compounds, the so-called fat-soluble vitamins. Because of their lipophilicity, fat-soluble vitamins are solubilised and transported by intracellular carrier proteins to exert their actions. Alpha-tocopherol, the main form of vitamin E found in the body, is transported by alpha-tocopherol transfer protein (TTPA) in hepatic cells (Kono & Arai 2015, Schmolz et al. 2016). View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 8877627
Reactome-version 
Reactome version: 74
Reactome Author 
Reactome Author: Jassal, Bijay

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Kostner GM, Oettl K, Jauhiainen M, Ehnholm C, Esterbauer H, Dieplinger H.; ''Human plasma phospholipid transfer protein accelerates exchange/transfer of alpha-tocopherol between lipoproteins and cells.''; PubMed Europe PMC Scholia
  2. Traber MG, Ramakrishnan R, Kayden HJ.; ''Human plasma vitamin E kinetics demonstrate rapid recycling of plasma RRR-alpha-tocopherol.''; PubMed Europe PMC Scholia
  3. Qian J, Morley S, Wilson K, Nava P, Atkinson J, Manor D.; ''Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein.''; PubMed Europe PMC Scholia
  4. Kono N, Arai H.; ''Intracellular transport of fat-soluble vitamins A and E.''; PubMed Europe PMC Scholia
  5. Schmölz L, Birringer M, Lorkowski S, Wallert M.; ''Complexity of vitamin E metabolism.''; PubMed Europe PMC Scholia
  6. Arita M, Sato Y, Miyata A, Tanabe T, Takahashi E, Kayden HJ, Arai H, Inoue K.; ''Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
114866view16:37, 25 January 2021ReactomeTeamReactome version 75
113312view11:38, 2 November 2020ReactomeTeamReactome version 74
112523view15:48, 9 October 2020ReactomeTeamReactome version 73
101435view11:31, 1 November 2018ReactomeTeamreactome version 66
100974view21:08, 31 October 2018ReactomeTeamreactome version 65
100511view19:42, 31 October 2018ReactomeTeamreactome version 64
100057view16:26, 31 October 2018ReactomeTeamreactome version 63
99609view14:59, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93595view11:28, 9 August 2017ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
TTPA ProteinP49638 (Uniprot-TrEMBL)
TTPA:alpha-TOHComplexR-HSA-8874714 (Reactome)
TTPA:alpha-TOHComplexR-HSA-8874722 (Reactome)
TTPAProteinP49638 (Uniprot-TrEMBL)
alpha-TOH MetaboliteCHEBI:18145 (ChEBI)
alpha-TOHMetaboliteCHEBI:18145 (ChEBI)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
R-HSA-8874705 (Reactome) Alpha-tocopherol (alpha-TOH) belongs to the fat-soluble vitamin E family and is the major form used by humans as an important antioxidant of plasma lipoproteins and cell membranes. It is secreted from the liver into the blood stream but as it is a lipophilic compound, it requires intracellular binding proteins to bind and transport it to exert its actions. One such protein is alpha-tocopherol transfer protein (TTPA, TPP1), a cytosolic protein highly expressed in liver and placenta (Arita et al. 1995, Kostner et al. 1995). The main function of TTPA is to maintain normal alpha-TOH concentrations in the plasma and extrahepatic tissues by binding to, and facilitating the transport of, alpha-TOH from lysosomes to the plasma membrane followed by the continuous export of alpha-TOH from the liver to the plasma (Traber et al. 1994, Qian et al. 2005; reviews Kono & Arai 2015, Schmolz et al. 2016).
R-HSA-8874718 (Reactome) Alpha-tocopherol (alpha-TOH) belongs to the fat-soluble vitamin E family and is the major form used by humans as an important antioxidant of plasma lipoproteins and cell membranes. It is secreted from the liver into the blood stream but as it is a lipophilic compound, it requires intracellular binding proteins to bind and transport it to exert its actions. One such protein is alpha-tocopherol transfer protein (TTPA, TPP1), a cytosolic protein highly expressed in liver and placenta (Arita et al. 1995, Kostner et al. 1995). The main function of TTPA is to maintain normal alpha-TOH concentrations in the plasma and extrahepatic tissues by binding to, and facilitating the transport of, alpha-TOH from lysosomes to the plasma membrane (Qian et al. 2005; reviews Kono & Arai 2015, Schmolz et al. 2016).
TTPA:alpha-TOHArrowR-HSA-8874705 (Reactome)
TTPA:alpha-TOHArrowR-HSA-8874718 (Reactome)
TTPA:alpha-TOHR-HSA-8874705 (Reactome)
TTPAR-HSA-8874718 (Reactome)
alpha-TOHR-HSA-8874718 (Reactome)
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP4112"
Personal tools