Fluoroacetic acid toxicity (Homo sapiens)

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Aldehyde dehydrogenasesFluoroacetaldehydeAconitaseCytric acid cycle (Krebs cycle)Fluoroacetic AcidALDH3A2AcetateALDH2Isocitric acidAcetyl-CoA synthetaseFluoroacetyl-CoA4-hydroxy-trans-aconitateALDH9A1Citric acidCitrate synthaseFluorocitric acid


Description

Pathway on fluoroacetic acid toxicity describing how it ultimately leads to disturbance of the Krebs cycle.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Johnson BM, Shu YZ, Zhuo X, Meanwell NA; ''Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.''; J Med Chem, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141723view16:31, 22 November 2025EweitzClear deprecated metadata rendering
141722view16:31, 22 November 2025EweitzEconomize layout
134720view21:30, 26 July 2024EweitzFix typo
123489view04:48, 29 July 2022EgonwMade a pathway clickable
112070view10:14, 18 September 2020Marvin M2Ontology Term : 'altered metabolic pathway' added !
112069view10:14, 18 September 2020Marvin M2Ontology Term : 'altered citric acid cycle pathway' added !
112068view10:13, 18 September 2020DeSlOntology Term : 'disease pathway' added !
112067view10:09, 18 September 2020Marvin M2Added reference and minor layout edit
111923view06:49, 11 September 2020EgonwAdded the missing compound identifier.
111922view06:22, 11 September 2020EgonwModified description
111816view19:16, 8 September 2020Marvin M2changed secondary chebi IDs to primary chebi IDs.
111786view14:17, 7 September 2020Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-hydroxy-trans-aconitateMetaboliteQ76106265 (Wikidata)
ALDH2GeneProductENSG00000111275 (Ensembl)
ALDH3A2GeneProductENSG00000072210 (Ensembl)
ALDH9A1GeneProductENSG00000143149 (Ensembl)
AcetateMetabolite71-50-1 (CAS)
Acetyl-CoA synthetaseGeneProductENSG00000131069 (Ensembl)
AconitaseGeneProductENSG00000100412 (Ensembl)
Citrate synthaseGeneProduct1431 (Entrez Gene)
Citric acidMetaboliteCHEBI:30769 (ChEBI)
Cytric acid cycle (Krebs cycle)PathwayWP78 (WikiPathways)
FluoroacetaldehydeMetaboliteCHEBI:14272 (ChEBI)
Fluoroacetic AcidMetaboliteCHEBI:30775 (ChEBI)
Fluoroacetyl-CoAMetabolite49859653 (PubChem-compound)
Fluorocitric acidMetabolite357-89-1 (CAS)
Isocitric acidMetaboliteCHEBI:30887 (ChEBI)

Annotated Interactions

No annotated interactions

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