Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition (Homo sapiens)
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Description
Adverse Outcome Pathway (AOP) for mitochondrial Complex 1 (C1) inhibition.
Adverse Outcome Pathways (AOPs), in general, are defined as a sequence of key events that begins with a molecular initiating event (MIE) and leads to an Adverse Outcome. At that level, AOPs are described in the AOPWiki. Relevant AOPs for the understanding of the one depicted here is AOPwiki:3, and a few others are under development.
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Ontology Terms
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| Apoptosis | Pathway | WP1772 (WikiPathways)  | |
| Autophagy | Pathway | WP4923 (WikiPathways) | |
| Decreased mitochondrial oxidative phosphorylation | Pathway | WP111 (WikiPathways) | |
| Decreased proximal tubule vectorial transport | Pathway | WP4917 (WikiPathways) | |
| Degeneration of DA neurons of nigrostratial pathway | Pathway | WP2855 (WikiPathways) | |
| Deguelin | Metabolite | CHEBI:4357 (ChEBI) | |
| Ferroptosis | Pathway | WP4313 (WikiPathways) | |
| Impaired proteostasis | Pathway | WP4918 (WikiPathways) | |
| Increased ROS | Pathway | WP3941 (WikiPathways) | |
| Inhibition of mitochondrial Complex I | Pathway | WP4324 (WikiPathways) | |
| Necrosis | Pathway | WP3383 (WikiPathways) | |
| Neuroinflammation | Pathway | WP4919 (WikiPathways) | |
| Parkinsonian motor deficits | Pathway | WP2371 (WikiPathways) | |
| Rotenone | Metabolite | CHEBI:28201 (ChEBI) | |
| UPR | Pathway | WP4925 (WikiPathways) |
Annotated Interactions
No annotated interactions
