Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins (Homo sapiens)

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LegendAutophagosome/Autophagy receptors Phagophorecargo sequestrationPhospho(S/T) siteAccumulation of autophagy receptors HOPS COMPLEXRPTORVPS16ATG3VPS11RHEBAKTS1VPS18MTORMAP1LC3BVPS33AATG5P70S6KATG9AATG7AKT1ORF3ORF3OPTNHOPS COMPLEXATG16LGSK3ATG4ATG12VPS36mTORC1VPS41SQSTM1DEPTORMLST8TAX1BP1SNAREsGABARAPL2CALCOCO2LARP1TSC2RPS6RAB7AAMPKNRB1PKMFIP200ULK1ATG13S203K24 S366S272S479S738S238S735K143S18S766S355K435 S361K157T269K149T525K74S638S477K82K46S1347K281T1162S202K97S240LysosomeAutophagolysosomeFusionLate endosomeUbiqutination (K) siteBindingInteractionUpregulationSARS-CoV-2 proteinInhibitionNSP61


Description

Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2, derived from the network diffusion model and overlaid with the changes in protein levels, ubiquitination and phosphorylation induced by SARS-CoV-2 infection.

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Ontology Terms

 

Bibliography

  1. Alexey Stukalov, Virginie Girault, Vincent Grass, Valter Bergant, Ozge Karayel, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, Sabri M. Hamad, Antonio Piras, Maria Tanzer, Fynn M. Hansen, Thomas Enghleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volker Thiel, Pietro Scaturro, Matthias Mann, Andreas Pichlmair; ''Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV''; Nature, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140460view19:00, 26 August 2025KhanspersModified description
139767view13:37, 4 July 2025DdiglesDeleted hidden old descriptions
129410view09:13, 12 April 2024EgonwUpdated a few more NCBI Gene data sources
129409view08:44, 12 April 2024EgonwUpdated a number of NCBI Gene data sources
124645view13:04, 18 November 2022NhungPupdate viral proteins shapes and labels
124432view12:50, 27 October 2022Mkutmonlower case SARS-CoV-2 protein names
123344view09:47, 17 July 2022EgonwORF3a is the only one with enough amino acids to be structure in Figure 3, and must be the ORF3 in the article
120658view18:36, 22 December 2021EweitzModified title
119426view22:47, 28 June 2021KhanspersAdded more ptm comments
119425view22:28, 28 June 2021KhanspersAdded phosphorylation comments for data mapping
119424view21:47, 28 June 2021Khanspersupdated based on the published figure
119389view21:19, 25 June 2021KhanspersAdded nodes and updated layout
119332view21:15, 23 June 2021Khanspersupdated style and specified ptms
119110view13:21, 17 June 2021Finterlyadded PMID
118873view12:01, 3 June 2021EweitzOntology Term : 'COVID-19' added !
115858view15:54, 18 March 2021Marvin M2Changed legend to graphical elements
115855view15:44, 18 March 2021Marvin M2added annotations
115839view14:52, 18 March 2021Marvin M2corrected ref
115836view14:35, 18 March 2021Marvin M2connected lines, some annotations
114087view08:27, 21 December 2020EgonwTyped 'phagophore' and give it an identifier
114075view06:17, 21 December 2020EgonwConverted a label involved in an interaction into a DataNode
112887view13:08, 15 October 2020Fehrhartfixed unconnected lines
111196view04:21, 24 July 2020Rex D A BConnections
111139view16:37, 17 July 2020EgonwColored the proteins according to the COVID19 Disease Maps convention
111028view06:22, 1 July 2020EgonwUpdated the UniProt data source
110916view04:32, 21 June 2020Rex D A BOntology Term : 'altered autophagy pathway' added !
110915view04:30, 21 June 2020Rex D A BOntology Term : 'infectious disease pathway' added !
110914view04:18, 21 June 2020Rex D A BModified description
110913view04:17, 21 June 2020Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
GeneProduct
AKT1ProteinP31749 (Uniprot-SwissProt)
AKTS1GeneProduct
AMPKProtein5563 (NCBI Protein)
ATG12Protein9140 (NCBI Protein)
ATG13Protein9776 (NCBI Protein)
ATG16LProtein55054 (NCBI Protein)
ATG3Protein64422 (NCBI Protein)
ATG4GeneProduct
ATG5Protein9474 (NCBI Protein)
ATG7Protein10533 (NCBI Protein)
ATG9AProtein79065 (NCBI Protein)
CALCOCO2Protein10241 (NCBI Protein)
DEPTORProtein64798 (NCBI Protein)
FIP200Protein9821 (NCBI Protein)
GABARAPL2Protein11345 (NCBI Protein)
GSK3ProteinP31749 (NCBI Protein)
HOPS COMPLEXGeneProductHOPS COMPLEX
LARP1GeneProductLARP1
MAP1LC3BGeneProduct81631 (NCBI Protein)
MLST8Protein64223 (NCBI Protein)
MTORProtein2475 (NCBI Protein)
NRB1GeneProduct
NSP6ProteinYP_009725302 (NCBI Protein)
OPTNProtein10133 (NCBI Protein)
ORF3GeneProductORF3
P70S6KGeneProduct
PKMProtein5315 (NCBI Protein)
RAB7AProtein7879 (NCBI Protein)
RHEBProtein6009 (NCBI Protein)
RPS6Protein6194 (NCBI Protein)
RPTORProtein57521 (NCBI Protein)
SNAREsGeneProduct
SQSTM1Protein8878 (NCBI Protein)
TAX1BP1Protein8887 (NCBI Protein)
TSC2ProteinP31749 (NCBI Protein)
ULK1Protein8408 (NCBI Protein)
VPS11Protein55823 (NCBI Protein)
VPS16Protein64601 (NCBI Protein)
VPS18GeneProductVPS18
VPS33AProtein65082 (NCBI Protein)
VPS36Protein51028 (NCBI Protein)
VPS41Protein27072 (NCBI Protein)
mTORC1GeneProduct

Annotated Interactions

No annotated interactions

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