COVID-19, thrombosis and anticoagulation (Homo sapiens)

From WikiPathways

Revision as of 12:19, 13 May 2020 by DeSl (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Fibrin MeshFactor XIII:Relevant other pathways:FibrinogenThrombinPlatelet-mediated interactions with vascular and circulating cellsFactor XIII A chainEFormation of Fibrin Clot (Clotting Cascade)DDBlood Clotting CascadeBlood clotting and drug effectsComplement and Coagulation CascadesFibrinEDDFibrinDEDFibrinDDEFibrinEDDFibrinDEDFibrinDDEFibrinEDDFibrinDEDFactor XIII B chainCrosslinkedFibrin Mesh


Description

new

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Velavan TP, Meyer CG; ''Mild versus severe COVID-19: Laboratory markers.''; Int J Infect Dis, 2020 PubMed Europe PMC Scholia
  2. Adam SS, Key NS, Greenberg CS; ''D-dimer antigen: current concepts and future prospects.''; Blood, 2009 PubMed Europe PMC Scholia
  3. Glenn KC, Frost GH, Bergmann JS, Carney DH; ''Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis.''; Pept Res, 1988 PubMed Europe PMC Scholia
  4. Ichinose A, McMullen BA, Fujikawa K, Davie EW; ''Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments.''; Biochemistry, 1986 PubMed Europe PMC Scholia
  5. Thomas A, Biswas A, Dodt J, Philippou H, Hethershaw E, Ensikat HJ, Ivaskevicius V, Oldenburg J; ''Coagulation Factor XIIIA Subunit Missense Mutations Affect Structure and Function at the Various Steps of Factor XIII Action.''; Hum Mutat, 2016 PubMed Europe PMC Scholia
  6. Kirschbaum NE, Budzynski AZ; ''A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
  7. Connors JM, Levy JH; ''COVID-19 and its implications for thrombosis and anticoagulation.''; Blood, 2020 PubMed Europe PMC Scholia
  8. Redman CM, Xia H; ''Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion.''; Ann N Y Acad Sci, 2001 PubMed Europe PMC Scholia
  9. Muszbek L, Bereczky Z, Bagoly Z, Komáromi I, Katona É; ''Factor XIII: a coagulation factor with multiple plasmatic and cellular functions.''; Physiol Rev, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141026view12:53, 2 November 2025EweitzClear deprecated metadata rendering
137632view21:49, 5 March 2025KhanspersModified description
121715view13:49, 26 February 2022EweitzModified description
120608view23:33, 17 December 2021EweitzRefine case, copy
118848view09:24, 2 June 2021EweitzOntology Term : 'hepatocyte' added !
118847view09:24, 2 June 2021EweitzOntology Term : 'COVID-19' added !
118846view09:23, 2 June 2021EweitzOntology Term : 'DOID:2945' removed !
115849view15:25, 18 March 2021DeSlAdded refs for XIII (A and B)
115848view15:22, 18 March 2021DeSlAdded ref for plasmin conversion
115847view15:20, 18 March 2021DeSlAdded ref for thrombin conversion
115845view15:18, 18 March 2021DeSlAdded additional inhibitors for degradation, including ref.
115844view15:11, 18 March 2021DeSlAdded first proteolytic inhibitors
115842view15:05, 18 March 2021DeSlAdded refs for degradation steps
115841view15:04, 18 March 2021DeSlAdded degradation steps
115838view14:48, 18 March 2021DeSlAdded details on fibrinogen in comments
115834view14:20, 18 March 2021DeSlAdded PMID:11460506 for interactions within hepatocyte (middle of model)
111155view08:37, 21 July 2020EgonwFixed typo in ShapeType :/
111154view08:35, 21 July 2020EgonwMade the pathways clickable
110542view09:44, 18 May 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
110541view09:44, 18 May 2020FehrhartOntology Term : 'disease pathway' added !
110537view15:37, 17 May 2020DeSlAdded details of Golgi step
110536view15:33, 17 May 2020DeSlAdded missing IDs D-dimer, new fibrinogen node
110535view14:48, 17 May 2020DeSlAdded lit. ref and more details on heximer formation
110534view14:37, 17 May 2020DeSlAdded hepatocyte
110533view13:20, 17 May 2020DeSlLast details on fibrinogen formation.
110532view13:10, 17 May 2020DeSlMore details on heximerisation
110529view12:13, 17 May 2020DeSlAdded additional details on fibrin formation
110525view11:47, 17 May 2020DeSlModified description
110524view11:42, 17 May 2020DeSlModified description
110523view07:22, 17 May 2020EgonwAdded an identifier for FDP
110516view10:57, 16 May 2020DeSlModified description
110515view10:54, 16 May 2020DeSlAdded D+E domain explanation
110514view10:46, 16 May 2020DeSlAdded IDs for alternative splicing D-domain
110513view10:43, 16 May 2020DeSlAdded D-domain alternative splicing
110512view10:36, 16 May 2020DeSlChanged double graphical lines to two singles for visualisation purpose.
110511view10:31, 16 May 2020DeSlAdded D-domain + IDs
110510view10:25, 16 May 2020DeSlStarting to add details on D-E-D glycotprotein
110492view11:59, 14 May 2020DeSlConnected unconnected line
110474view13:43, 13 May 2020DeSlModified description
110472view13:34, 13 May 2020DeSlModified description
110471view13:30, 13 May 2020DeSlOntology Term : 'blood coagulation disease' added !
110470view13:30, 13 May 2020DeSlOntology Term : 'thrombosis' added !
110468view12:29, 13 May 2020DeSlAdded ref covid + thrombosis
110467view12:28, 13 May 2020DeSlAdded refs
110466view12:23, 13 May 2020DeSlAdded D-Dimer step
110465view12:19, 13 May 2020DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Blood Clotting CascadePathwayWP272 (WikiPathways)
Blood clotting and drug effectsPathwayWP4580 (WikiPathways)
Complement and Coagulation CascadesPathwayWP558 (WikiPathways)
Factor XIII A chainProteinP00488 (Uniprot-TrEMBL) Catalytically active
Factor XIII B chainProteinP05160 (Uniprot-TrEMBL) Not catalytically active, believed to stabilise A chain
FibrinMetaboliteQ27205 (Wikidata)
FibrinogenMetaboliteQ381899 (Wikidata)
Formation of Fibrin Clot (Clotting Cascade)PathwayWP1818 (WikiPathways)
Platelet-mediated interactions with vascular and circulating cellsPathwayWP4462 (WikiPathways)
ThrombinProteinP00734 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP4927"
Personal tools