Host-pathogen interaction of human coronaviruses - autophagy (Homo sapiens)

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1EDEMosomeDMVdouble membranevesicleMaturationphosphorylationSARS, IBV, MHV(inactive)InitiationWIPI1RB1CC1ATG12ULK2PIK3R4ATG10ATG13ATG3nsp6autophagyinitiationcomplexULK1ATG7MTORMAP1LC3AZFYVE1PIK3C3BECN1LPULK1PULK2PMTORERNucleationElongationAutophagosomeMAP1LC3Ansp567PRRSVMHV, EAVinfectionSARS, IBV, MHVnsp6nsp567PRRSVLysosomeAutolysosomeATG4AATG12LATG7virus type/proteinPhosphorylationLipidationPRRSVPL


Description

Induction and modulation of autophagy system during human corona virus infection.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia
  2. Cottam EM, Whelband MC, Wileman T; ''Coronavirus NSP6 restricts autophagosome expansion.''; Autophagy, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142020view13:22, 29 November 2025EweitzRefine legend
124639view12:47, 18 November 2022Mkutmonupdate virus proteins style
116597view19:12, 8 May 2021EweitzModified title
112163view18:30, 29 September 2020Khanspersfixed ptm state comments
110820view07:40, 10 June 2020FehrhartModified description
110819view07:38, 10 June 2020Fehrhartadded reference
110814view22:43, 9 June 2020Mkutmonfixed unconnected line
110727view19:00, 29 May 2020Khansperschanged xrefs to uniprot
110726view18:47, 29 May 2020Khanspersupdated legend, updated ATG part, changed free labels into labels on objects
110725view17:58, 29 May 2020Khanspersadded phosphosites for ULK1, updated representation of ULK/ATG13 dephosphorylation, updated legend
110204view10:47, 24 April 2020Fehrhartupdated legend
110199view20:38, 23 April 2020EgonwTyped proteins as Type="Protein"
109983view21:26, 8 April 2020EgonwAdded possibly the first complex identifier.
109982view21:13, 8 April 2020EgonwAdded a Complex data node (with title from Complex Portal)
109972view18:17, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109848view11:34, 2 April 2020Fehrhartchanged virus protein visualization
109820view15:01, 1 April 2020FehrhartFixed a comment error
109633view18:28, 27 March 2020AlexanderPicoOntology Term : 'autophagy pathway' added !
109629view18:26, 27 March 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
109628view18:21, 27 March 2020AlexanderPicoAdded P and L modifications as states
109627view18:09, 27 March 2020FehrhartOntology Term : 'viral infectious disease' added !
109626view18:09, 27 March 2020FehrhartOntology Term : 'disease pathway' added !
109625view18:09, 27 March 2020FehrhartModified title
109624view18:06, 27 March 2020FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATG10GeneProductENSG00000152348 (Ensembl)
ATG12GeneProductENSG00000145782 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
ATG3GeneProductENSG00000144848 (Ensembl)
ATG4AGeneProductENSG00000101844 (Ensembl)
ATG7GeneProductENSG00000197548 (Ensembl)
BECN1GeneProductENSG00000126581 (Ensembl) beclin 1
MAP1LC3AGeneProductENSG00000101460 (Ensembl) LC3
MTORGeneProductENSG00000198793 (Ensembl)
PIK3C3GeneProductENSG00000078142 (Ensembl) VPS34
PIK3R4GeneProductENSG00000196455 (Ensembl) VPS15
RB1CC1GeneProductENSG00000023287 (Ensembl) FIP200
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
WIPI1GeneProductENSG00000070540 (Ensembl)
ZFYVE1GeneProductENSG00000165861 (Ensembl)
autophagy

initiation

complex		Complex
nsp567GeneProduct
nsp6GeneProduct

Annotated Interactions

No annotated interactions

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