Kisspeptin/kisspeptin receptor system in the ovary (Homo sapiens)

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1StimulationRafOvulationInhibitionOocyte maturationLegendGq/11 protein signallingProtein kinase CFollicular developmentPathwayIndirect conversion/interactionErkCatalysisIndirect stimulationIntracellular spaceConversionRasMekMetaboliteSteroidogenesisGene productGenePLCB2CYP11A1PRKCHPLCB1DAGARRB1PIP2KISS1MAPK signalling pathwayPIP3PRKCBMAP2K1NFKB1Ca2+AMHGDF9KISS1RHSD3B1IP3KRASSTARPRKCAPLCB3MAPK1progesteronePIK3CDMAP2K2FSHRPIK3CGNKBPRKCGMMP9PRKCQMAPK3PIK3CBPLCB4MetPathwayPIK3CAPDK1BMP15PRKCDARRB2HRASAKT1RAF1NRASPRKCEAKT2PI3K/Akt signalling pathwayExtracellular space


Description

The signalling pathway of the kisspeptin/kisspeptin receptor interaction in the ovary, including its effects on follicular development, oocyte maturation, ovulation, and steroidogenesis.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hu KL, Zhao H, Chang HM, Yu Y, Qiao J; ''Kisspeptin/Kisspeptin Receptor System in the Ovary.''; Front Endocrinol (Lausanne), 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140110view05:37, 29 July 2025EgonwCalcium ion with unicode
128771view23:21, 21 February 2024EweitzEconomize layout
128770view23:14, 21 February 2024EweitzRefine legend, standardize case
120412view09:31, 30 November 2021Fehrhartboxed pathway nodes
116444view09:50, 7 May 2021EweitzModified title
110295view14:23, 2 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110078view09:06, 16 April 2020FehrhartChanged pathway to label in legend
110077view09:04, 16 April 2020FehrhartConverted interactions in legend to graphical lines
109733view22:00, 29 March 2020MCMJanssenOntology Term : 'ovarian disease' added !
109732view21:59, 29 March 2020MCMJanssenOntology Term : 'female reproductive system disease' added !
109731view21:59, 29 March 2020MCMJanssenOntology Term : 'sex steroids signaling pathway' added !
109730view21:58, 29 March 2020MCMJanssenOntology Term : 'nuclear factor kappa B signaling pathway' added !
109729view21:58, 29 March 2020MCMJanssenOntology Term : 'protein kinase C (PKC) signaling pathway' added !
109728view21:57, 29 March 2020MCMJanssenOntology Term : 'peptide and protein hormone signaling pathway' added !
109727view21:57, 29 March 2020MCMJanssenOntology Term : 'G protein mediated signaling pathway' added !
109722view17:21, 29 March 2020MCMJanssenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AMHGeneProductENSG00000104899 (Ensembl)
ARRB1GeneProductENSG00000137486 (Ensembl)
ARRB2GeneProductENSG00000141480 (Ensembl)
BMP15GeneProductENSG00000130385 (Ensembl)
CYP11A1GeneProductENSG00000140459 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
DAGMetaboliteCHEBI:4481 (ChEBI)
FSHRGeneProductENSG00000170820 (Ensembl)
GDF9GeneProductENSG00000164404 (Ensembl)
GeneGeneProduct
HRASGeneProductENSG00000174775 (Ensembl)
HSD3B1GeneProductENSG00000203857 (Ensembl)
IP3MetaboliteCHEBI:16595 (ChEBI)
KISS1GeneProductENSG00000170498 (Ensembl)
KISS1RGeneProductENSG00000116014 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK signalling pathwayPathwayWP382 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MetMetabolite
NFKB1GeneProductENSG00000109320 (Ensembl)
NKBMetaboliteQ412604 (Wikidata)
NRASGeneProductENSG00000213281 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PI3K/Akt signalling pathwayPathwayWP4172 (WikiPathways)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
PRKCDGeneProductENSG00000163932 (Ensembl)
PRKCEGeneProductENSG00000171132 (Ensembl)
PRKCGGeneProductENSG00000126583 (Ensembl)
PRKCHGeneProductENSG00000027075 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
PathwayPathway
RAF1GeneProductENSG00000132155 (Ensembl)
STARGeneProductENSG00000147465 (Ensembl)
progesteroneMetaboliteCHEBI:8453 (ChEBI)

Annotated Interactions

No annotated interactions

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