Splicing factor NOVA regulated synaptic proteins (Homo sapiens)

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1, 2LegendPost-synaptic neuronCAV2EPB41L2MAPK4CDH2LARSNW1MAP4AGRNCLSTN1EphrinA5RKCNJ6PIP2CLASP1KCNMA1CASKNCDNGlyRa2GABRG2MAPK9ATP2B1Syntaxin1PLCB4RAP1GAPSTX2CAMK2Ga-cateninCADM1NEO1nAChRa2CAV2CASKGPHNCSN3DAB1APLP2KCNQ2STXBP2EPB41EPB41L3CHL1NTNG1TERF2IPEFNA5GRIN2BGRIN1CHL1CDH2ANK3CASKDAB1a-cateninLARGRIK2CASKPRKCZGABBR2nAChRa4PLCB4PIP2ANK3ANK3MAPK9EPB41EPB41GRIK2KCNMA1PRKCZGABBR2GPHNPre-synaptic neuronPLCB4EPB41L1CADM3Integrin a2validated targetCLIP predicted targetvalidated target - predicted by bioinformaticsvalidated target - predicted by splicing microarrayvalidated target - predicted by CLIP


Description

Synaptic Communication influenced by NOVA-splicing regulation. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway WP1983 (rev 89961) with a 85.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Ule J, Ule A, Spencer J, Williams A, Hu JS, Cline M, Wang H, Clark T, Fraser C, Ruggiu M, Zeeberg BR, Kane D, Weinstein JN, Blume J, Darnell RB; ''Nova regulates brain-specific splicing to shape the synapse.''; Nat Genet, 2005 PubMed Europe PMC Scholia
  2. J. Ule, G. Stefani, A. Mele, M. Ruggiu, X. Wang, B. Taneri, T. Gaasterland, B.J. Blencowe, R.B. Darnell; ''An RNA map predicting Nova-dependent splicing regulation.''; Nature, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137942view18:37, 10 March 2025KhanspersModified description
110682view13:12, 28 May 2020Fehrhartreplaced legend nodes by labels
106777view13:25, 17 September 2019MaintBotHMDB identifier normalization
105821view23:02, 15 August 2019KhanspersModified description
94396view12:34, 6 September 2017MkutmonOntology Term : 'cadherin mediated signaling pathway' added !
94395view12:33, 6 September 2017MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AGRNProteinENSG00000188157 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A2ASQ1
ANK3GeneProductENSG00000151150 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11735
APLP2GeneProductENSG00000084234 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031996
ATP2B1GeneProductENSG00000070961 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67972
CADM1GeneProductENSG00000182985 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54725
CADM3GeneProductENSG00000162706 (Ensembl)
  • Validated target - predicted by bioinformatics
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94332
CAMK2GGeneProductENSG00000148660 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021820
CASKGeneProductENSG00000147044 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031012
CAV2GeneProductENSG00000105971 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000058
CDH2GeneProductENSG00000170558 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12558
CHL1GeneProductENSG00000134121 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030077
CLASP1GeneProductENSG00000074054 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000064302
CLIP predicted targetCLIP predicted target
CLSTN1GeneProductENSG00000171603 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:65945
CSN3ProteinENSG00000171209 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P06796
DAB1GeneProductENSG00000173406 (Ensembl)
  • Validated target - predicted by bioinformatics
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028519
EFNA5GeneProductENSG00000184349 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13640
EPB41GeneProductENSG00000159023 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:269587
EPB41L1GeneProductENSG00000088367 (Ensembl)
  • Validated target - predicted by bioinformatics
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13821
EPB41L2GeneProductENSG00000079819 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13822
EPB41L3GeneProductENSG00000082397 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13823
EphrinA5RGeneProductValidated target - predicted by splicing microarray
GABBR2GeneProductENSG00000136928 (Ensembl)
  • CLIP predicted target
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:242425
GABRG2GeneProductENSG00000113327 (Ensembl)
  • Validated target
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14406
GPHNGeneProductENSG00000171723 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:268566
GRIK2GeneProductENSG00000164418 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14806
GRIN1GeneProductENSG00000176884 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14810
GRIN2BGeneProductENSG00000273079 (Ensembl)
  • CLIP predicted target
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14812
GlyRa2GeneProductValidated target
Integrin a2 GeneProductValidated target - predicted by bioinformatics
KCNJ6GeneProductENSG00000157542 (Ensembl)
  • CLIP predicted target
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16522
KCNMA1GeneProductENSG00000156113 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16531
KCNQ2GeneProductENSG00000075043 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000016346
LAR GeneProductValidated target - predicted by splicing microarray
MAP4ProteinENSG00000047849 (Ensembl)
  • Validated target - predicted by bioinformatics
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P27546
MAPK4GeneProductENSG00000141639 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024558
MAPK9GeneProductENSG00000050748 (Ensembl)
  • Validated target - predicted by CLIP
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26420
NCDNGeneProductENSG00000020129 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26562
NEO1GeneProductENSG00000067141 (Ensembl)
  • Validated target - predicted by CLIP
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18007
NTNG1GeneProductENSG00000162631 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80883
PIP2 MetaboliteHMDB0010032 (HMDB)
PLCB4GeneProductENSG00000101333 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039943
PRKCZGeneProductENSG00000067606 (Ensembl)
  • CLIP predicted target
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18762
RAP1GAPGeneProductENSG00000076864 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110351
SNW1GeneProductENSG00000100603 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66354
STX2GeneProductENSG00000111450 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13852
STXBP2GeneProductENSG00000076944 (Ensembl)
  • Validated target - predicted by splicing microarray
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20911
Syntaxin1GeneProduct
TERF2IPGeneProductENSG00000166848 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57321
a-catenin GeneProductValidated target - predicted by splicing microarray
nAChRa2GeneProductCLIP predicted target
nAChRa4GeneProductCLIP predicted target
validated targetValidated target
validated target - predicted by CLIPValidated target - predicted by CLIP
validated target - predicted by bioinformaticsValidated target - predicted by bioinformatics
validated target - predicted by splicing microarrayValidated target - predicted by splicing microarray

Annotated Interactions

No annotated interactions
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