Metabolism of sphingolipids in ER and Golgi apparatus (Homo sapiens)

From WikiPathways

Revision as of 13:25, 17 September 2019 by MaintBot (Talk | contribs)
Jump to: navigation, search
SPHK2SPHK11Endoplasmic ReticulumTranslocation from ER to Golgi apparatusGalactosyltransferase (GalT1)GalNacTsphingosine kinaseneutral GSLsSATIGT3GA2GD3GM3B3GALNT1ethanolamine phosphateDihydroceramideSphinganine3-ketosphinganineCeramidehexadecanalSphinganine 1-phosphateSphingosineSphingosine-1-phosphateSPL1SPHK2SPHK1sphingosine kinaseSPGG1SPGG2SPGG1SPGG2SPTLC1P1SPTLC1P2SPTLC1P3SPTLC1P4SPTLC1P5KDSRCERS3Golgi apparatusgalactosyl-ceramideceramide-1-phosphateGalCer synthaseCERKSphingomyelinglucosylceramideSulfatidegalactosylceramideSGMS2GlcCer synthaselactosylceramideB3GALT1B4GALNT1B4GALT1GALNTL1GALNT1serinePalmitoyl CoACeramidegalactosyl-ceramideDEGS2DEGS1Dihydroceramide desaturaseSPL1GM2GM1aGD1aGD2GD1bGT1bGT2GT1cGQ1cGA1GM1bSATIVGalNacTGalNacTGalNacTSATIVSATIVSATIVSATIISATIIIB3GALT2B4GALT2B3GALT2B4GALT2B3GALT2B4GALT2B3GALT2B4GALT2SGMS1


Description

The metabolism of SphingoLipids (SLs) in the ER and Golgi apparatus. Sphingolipids, or glycosyl-ceramides, are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. These compounds play important roles in signal transmission and cell recognition.

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

  1. Lahiri, S., A. H. Futerman; ''The metabolism and function of sphingolipids and glycosphingolipids''; Cellular and Molecular Life Sciences, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139816view08:52, 7 July 2025DdiglesDeleted hidden old description
128518view01:06, 11 February 2024EweitzStandardize case
128517view01:06, 11 February 2024EweitzTweak tailoring
128516view01:05, 11 February 2024EweitzRefine tailored fix of site-PathVisio graphics discrepancy
128515view01:03, 11 February 2024EweitzFix site-PathVisio graphics descrepancy to favor site, soften Golgi apparatus area background color, standardize case
124466view08:30, 30 October 2022DdiglesModified title
119292view11:06, 23 June 2021Finterlyadded PMID
117156view09:46, 18 May 2021EweitzModified title
110014view18:33, 12 April 2020EgonwRemoved the RHEA: prefix.
108860view15:01, 3 February 2020DeSlChanged arrowd to MIM_translocation for Er to Golgi interactions.
108859view15:00, 3 February 2020DeSlChanged spingosine kinase ID from Wikidata to EC number.
108858view14:58, 3 February 2020DeSlChanged Wikidata ID to Uniprot for CERK.
108857view14:57, 3 February 2020DeSlChanged SPL1 ID from Uniprot to Wikidata; added Rhea ID for reaction to hexadecanal (from sphinganine).
108856view14:52, 3 February 2020DeSlChanged Wikidata ID to Uniprot for GlcCer synthase.
108855view14:48, 3 February 2020DeSlAdded Uniprot for SGMS2 iso Wikidata.
108854view14:46, 3 February 2020DeSlChanged SPTLC1P1/2/3/4/5 IDs from Wikidata to Entrez Gene (all pseudogenes, no Uniprot ID findable).
108853view14:42, 3 February 2020DeSlAdded uniprot ID for SGMS1, added rhea ID for reaction to sphingomyelin (parent reaction).
108852view14:39, 3 February 2020DeSlAdded Uniprot ID for SPGG2 iso wikidata.
108851view14:36, 3 February 2020DeSlAdded Uniprot for SPGG1 iso Wikidata, annotated 1 reaction with rhea ID.
108850view14:33, 3 February 2020DeSlChanged B3GalT2 Wikidata to Uniprot ID.
108849view14:31, 3 February 2020DeSlAdded Uniprot ID for B4GalT2
108798view13:33, 30 January 2020DeSlUpdated KDSR, CERS3 and GalCer synthase IDs (wikidata -. Uniprot).
108797view12:30, 30 January 2020DeSlRemoved EC before IDs
106776view13:25, 17 September 2019MaintBotHMDB identifier normalization
97513view13:43, 24 May 2018Youssefwalid
97509view13:38, 24 May 2018YoussefwalidChanged mapping of SATIII to UniprotSwiss
96377view06:42, 11 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95051view14:18, 10 November 2017DeSlChanged metabolite nodes to protein nodes.
95050view13:55, 10 November 2017DeSlChanged metabolite nodes to enzyme nodes where appropriate.
94435view11:02, 8 September 2017DeSlConnected last line, changed name of wrong metabolite (one of the sphingosine nodes is actually sphingosine-1-phosphate).
94432view09:37, 8 September 2017DeSlAdded enzyme node (SGMS1) and identifier
94288view12:53, 31 August 2017DeSlChanged title
94287view12:19, 31 August 2017DeSlAdded everything after lactosylceramide.
94285view20:34, 30 August 2017DeSlOntology Term : 'lacto-series glycosphingolipid metabolic pathway' added !
94284view20:34, 30 August 2017DeSlOntology Term : 'glycosphingolipid metabolic pathway' added !
94283view20:27, 30 August 2017DeSlChanged appearance of PW.
94275view14:44, 30 August 2017DeSlOntology Term : 'sphingolipid metabolic pathway' added !
94274view14:44, 30 August 2017DeSlOntology Term : 'sphingolipid biosynthetic pathway' added !
94273view14:43, 30 August 2017DeSlModified description
94272view14:28, 30 August 2017DeSlMade 2 seperate nodes from palmitoyl CoA and Serine, drew lines for translocation.
94271view14:04, 30 August 2017DeSlAdded literature reference
94270view14:01, 30 August 2017DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-ketosphinganineMetaboliteQ27073739 (Wikidata)
B3GALNT1ProteinENSG00000169255 (Ensembl)
B3GALT1ProteinENSG00000172318 (Ensembl)
B3GALT2ProteinQ18033232 (Wikidata) GalTII = galactosyltransferase
B4GALNT1ProteinENSG00000135454 (Ensembl)
B4GALT1ProteinENSG00000086062 (Ensembl)
B4GALT2ProteinQ18033229 (Wikidata) GalTII = galactosyltransferase
CERKProteinQ5063674 (Wikidata) Ceramide Kinase
CERS3ProteinQ17113326 (Wikidata) dihydroceramide synthase
CeramideMetaboliteCHEBI:17761 (ChEBI)
DEGS1MetaboliteQ21105760 (Wikidata)
DEGS2MetaboliteQ21115762 (Wikidata)
Dihydroceramide desaturaseMetaboliteQ17117943 (Wikidata)
DihydroceramideMetaboliteHMDB0006752 (HMDB)
GA1MetaboliteCHEBI:27938 (ChEBI) ganglioside GA1
GA2MetaboliteCHEBI:27731 (ChEBI) ganglioside GA2
GALNT1ProteinENSG00000141429 (Ensembl)
GALNTL1ProteinQ8N428 (Uniprot-TrEMBL) GALNT16 Synonyms:GALNTL1 (uniprot)
GD1aMetaboliteCHEBI:18163 (ChEBI) ganglioside GD1a
GD1bMetaboliteCHEBI:28175 (ChEBI) ganglioside GD1b
GD2MetaboliteCHEBI:28648 (ChEBI) ganglioside GD2
GD3MetaboliteCHEBI:89636 (ChEBI) Ganglioside GD3
GM1aMetaboliteCHEBI:18216 (ChEBI) ganglioside GM1a
GM1bMetaboliteCHEBI:62370 (ChEBI) ganglioside GM1b
GM2MetaboliteCHEBI:51013 (ChEBI) ganglioside GM2
GM3MetaboliteCHEBI:15681 (ChEBI) ganglioside GM3
GQ1cMetaboliteCHEBI:87994 (ChEBI) ganglioside GQ1c
GT1bMetaboliteCHEBI:28058 (ChEBI) ganglioside GT1b
GT1cMetaboliteCHEBI:87992 (ChEBI) ganglioside GT1c
GT2MetaboliteCHEBI:61732 (ChEBI) ganglioside GT2
GT3MetaboliteCHEBI:28541 (ChEBI) ganglioside GT3
GalCer synthaseProteinQ18032287 (Wikidata) UGT8 / CGT
GalNacTProteinEC 2.4.1.41 (Enzyme Nomenclature) N-acetylgalactosaminetransferase
GlcCer synthaseProteinQ22678664 (Wikidata) glucosylceramide synthase (GCS)
KDSRProteinQ1143172 (Wikidata) 3-ketodihydrosphingosine reductase
Palmitoyl CoAMetaboliteQ3361645 (Wikidata)
SATIProteinEC 2.4.99.9 (Enzyme Nomenclature) sialyltransferase SAT1
SATIIProtein2.4.99.8 (Enzyme Nomenclature) sialyltransferase SAT2
SATIIIProteinQ8NDV1 (Uniprot-TrEMBL) sialyltransferase SAT3
SATIVProtein2.4.99.10 (Enzyme Nomenclature) sialyltransferase SAT4
SGMS1ProteinQ18053901 (Wikidata) Sphingomyelin synthase 1
SGMS2ProteinQ21123432 (Wikidata) Sphingomyelin synthase 2
SPGG1ProteinQ18047015 (Wikidata) sphingosine-1-phosphate phosphatase
SPGG2ProteinQ18049980 (Wikidata) sphingosine-1-phosphate phosphatase
SPHK1ProteinENSG00000176170 (Ensembl)
SPHK2ProteinENSG00000063176 (Ensembl)
SPL1ProteinQ21144795 (Wikidata) Sphingosine-1-phosphate lyase 1
SPTLC1P1ProteinQ18073548 (Wikidata) serine palmitoyltransferase
SPTLC1P2ProteinQ18073516 (Wikidata) serine palmitoyltransferase
SPTLC1P3ProteinQ18073519 (Wikidata) serine palmitoyltransferase
SPTLC1P4ProteinQ18073521 (Wikidata) serine palmitoyltransferase
SPTLC1P5ProteinQ18073551 (Wikidata) serine palmitoyltransferase
Sphinganine 1-phosphateMetaboliteQ27077062 (Wikidata)
SphinganineMetaboliteHMDB0000269 (HMDB)
SphingomyelinMetaboliteQ423143 (Wikidata)
Sphingosine-1-phosphateMetaboliteQ418267 (Wikidata)
SphingosineMetaboliteQ46298 (Wikidata)
SulfatideMetaboliteQ408584 (Wikidata)
ceramide-1-phosphateMetaboliteQ35664620 (Wikidata) Cer-1-P
ethanolamine phosphateMetaboliteQ418826 (Wikidata)
galactosyl-ceramideMetaboliteQ2756638 (Wikidata) Galactocerebroside
galactosylceramideMetaboliteCHEBI:36498 (ChEBI) Gala-serie (=GalCer) GSLs (glycosphingolipids)
glucosylceramideMetaboliteQ35662896 (Wikidata)
hexadecanalMetaboliteQ27077978 (Wikidata)
lactosylceramideMetaboliteQ3215908 (Wikidata)
neutral GSLsMetaboliteCHEBI:25513 (ChEBI) neutral glycosphingolip = Any glycosphingolipid containing unsubstituted glycosyl moieties.
serineMetaboliteCHEBI:17822 (ChEBI)
sphingosine kinaseProteinQ7576797 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP4142"
Personal tools