Lidocaine metabolism (Homo sapiens)

Revision as of 13:16, 17 September 2019 by MaintBot (Talk | contribs)

Description

Lidocaine is primarily metabolized by CYP1A2 but minor involvement of CYP3A4 is observed too. Based on KEGG

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Isohanni MH, Neuvonen PJ, Olkkola KT; ''Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.''; Basic Clin Pharmacol Toxicol, 2006 PubMed Europe PMC Scholia
Wang JS, Backman JT, Wen X, Taavitsainen P, Neuvonen PJ, Kivistö KT; ''Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro.''; Pharmacol Toxicol, 1999 PubMed Europe PMC Scholia
Orlando R, Piccoli P, De Martin S, Padrini R, Floreani M, Palatini P; ''Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.''; Clin Pharmacol Ther, 2004 PubMed Europe PMC Scholia
Strong JM, Parker M, Atkinson AJ Jr; ''Identification of glycinexylidide in patients treated with intravenous lidocaine.''; Clin Pharmacol Ther, 1973 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
139959	view	10:11, 13 July 2025	Egonw	Added a reference
137745	view	17:54, 7 March 2025	Khanspers	Modified description
106722	view	13:16, 17 September 2019	MaintBot	HMDB identifier normalization
94915	view	00:13, 13 October 2017	Khanspers	moved link to KEGG
94737	view	15:03, 5 October 2017	Egonw	Added a missing mim-type.
92384	view	18:19, 31 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
74430	view	15:48, 18 April 2014	Egonw	Added a third reference.
74429	view	15:47, 18 April 2014	Egonw	Modified description
74428	view	15:43, 18 April 2014	Egonw	Added two literature references.
74427	view	15:36, 18 April 2014	Egonw	Ontology Term : 'phase I biotransformation pathway via cytochrome P450' added !
74424	view	15:33, 18 April 2014	Egonw	Removed a redundant (empty) comment.
74423	view	15:32, 18 April 2014	Egonw	New pathway

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Name	Type	Database reference
2,6-xylidine	Metabolite	CHEBI:28738 (ChEBI)
2-amino-3-methylbenzoate	Metabolite	4161142 (PubChem-compound)
3-hydroxylidocaine	Metabolite	161824 (PubChem-compound)
3-hydroxymonoethyl glycinexylidide	Metabolite	C16572 (KEGG Compound)
4-hydroxy- 2,6-dimethylaniline	Metabolite	CHEBI:55545 (ChEBI)
CYP1A2	GeneProduct	ENSG00000140505 (Ensembl)
CYP3A4	GeneProduct	ENSG00000160868 (Ensembl)
Lidocaine	Metabolite	HMDB0014426 (HMDB)
glycinexylidide	Metabolite	CHEBI:357241 (ChEBI)
monoethyl glycinexylidide	Metabolite	24415 (PubChem-compound)

No annotated interactions