Pathways of nucleic acid metabolism and innate immune sensing (Homo sapiens)

From WikiPathways

Revision as of 14:35, 16 September 2019 by DeSl (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
DNA damageLabelDNAreplicationUV lightNucleusIRF3dNTP poolscGASmRNADNATMEM173SAMHD1RetroelementdsDNATREX1STINGMAVScDNA1MDA5RIG-IdNssDNAssDNA


Description

No description

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

  1. Cho DS, Yang W, Lee JT, Shiekhattar R, Murray JM, Nishikura K; ''Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  2. Patterson JB, Samuel CE; ''''; , PubMed Europe PMC Scholia
  3. Deininger PL, Batzer MA; ''Mammalian retroelements.''; Genome Res, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136158view14:41, 20 December 2024EgonwModified description
128779view23:35, 21 February 2024EweitzUse standard shape for clickable pathways
128778view23:32, 21 February 2024EweitzRemove unnecessary background color, standardize case
123423view06:18, 26 July 2022EgonwMade a pathway clickable
119081view08:58, 16 June 2021DeSlUpdated sNTP pools ID
119080view05:36, 16 June 2021EgonwNot a mim-conversion
119064view07:46, 14 June 2021DeSlConverted last DNA and retroelement to RNA DataNodes
119063view07:44, 14 June 2021DeSlConverted some more Metabolites to RNA
119062view07:42, 14 June 2021DeSlUpdated some metabolites to RNA
118976view05:14, 6 June 2021EgonwdsRna is Rna
110737view09:55, 30 May 2020EgonwNot a mim-conversion
110687view13:32, 28 May 2020LaurentUpdated types of data nodes where type was missing
107300view12:13, 19 September 2019DeSlModified description
107299view12:12, 19 September 2019DeSlAdded missing IDs
107298view12:06, 19 September 2019DeSlOntology Term : 'altered DNA repair pathway' added !
107297view12:06, 19 September 2019DeSlOntology Term : 'signaling pathway in the innate immune response' added !
107296view12:05, 19 September 2019DeSlModified description
107295view12:00, 19 September 2019DeSlAdded rRNA part
107294view11:50, 19 September 2019DeSlAdded background colours, added Lysosome
107293view11:43, 19 September 2019DeSlAdded IFNB and ISGs
107291view11:37, 19 September 2019DeSlAdded phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3)
107290view11:33, 19 September 2019DeSlCompleted right hand side of PW
107286view08:35, 19 September 2019DeSlAdded more details on dsRNA interaction with MDA5
107183view14:27, 17 September 2019MaintBotChEBI identifier normalization
106678view15:09, 16 September 2019DeSlAdded more details on NER and RER
106677view14:35, 16 September 2019DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DNA replicationPathwayWP466 (WikiPathways)
DNAQ7430 (Wikidata)
IRF3ProteinQ14653 (Uniprot-TrEMBL)
MAVSProteinQ7Z434 (Uniprot-TrEMBL)
MDA5ProteinQ9BYX4 (Uniprot-TrEMBL)
RIG-IProtein
RetroelementQ1473344 (Wikidata)
SAMHD1ProteinQ9Y3Z3 (Uniprot-TrEMBL)
STINGProteinQ86WV6 (Uniprot-TrEMBL)
TMEM173GeneProductcGAS which signals via STING (encoded by TMEM173)
TREX1ProteinQ9NSU2 (Uniprot-TrEMBL) Cytosolic deoxyribonuclease anchored in the outer nuclear membrane. A lack of TREX1 causes DNA accumulation, both within the nucleus and the cytosol.
cDNAQ283478 (Wikidata) Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase.
cGASProteinQ8N884 (Uniprot-TrEMBL) DNA sensor
dNMetabolite18274 (ChEBI)
dNTP poolsMetabolite46149 (ChEBI)
dsDNAQ55978910 (Wikidata)
mRNAQ188928 (Wikidata)
ssDNAQ10906438 (Wikidata) single-stranded DNA

Annotated Interactions

SourceTargetTypeDatabase referenceComment
dNTP poolsdNmim-conversion46149 (Rhea) SAMHD1 degrades deoxynucleoside triphosphates (dNTP)
Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP4705"