Leptin and adiponectin (Homo sapiens)

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1beta-oxidationMitochondrionADIPOQFatty acidACACAADIPOR2Malonyl-CoAAcetyl-CoALEPFatty acidCPT1APRKAB1PRKAG1PRKAA1ADIPOR1LEPR


Description

Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in Dyck et al..


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Leptin and adiponectin", WP683 revision 71946, with a 100.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dyck DJ, Heigenhauser GJ, Bruce CR; ''The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity.''; Acta Physiol (Oxf), 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138699view19:23, 29 April 2025KhanspersUpdate cell shape, increase label font size, updated layout
137956view20:54, 10 March 2025KhanspersModified description
107151view14:23, 17 September 2019MaintBotChEBI identifier normalization
106628view20:54, 12 September 2019KhanspersModified description
105634view05:05, 10 August 2019KhanspersModified description
90768view01:17, 14 December 2016KhanspersOntology Term : 'glucose metabolism disease' added !
90767view01:16, 14 December 2016KhanspersOntology Term : 'leptin system pathway' added !
90766view01:16, 14 December 2016KhanspersOntology Term : 'adiponectin signaling pathway' added !
90765view01:16, 14 December 2016Khanspersupdated source pathway information
90764view01:15, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProductENSG00000278540 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107476
ADIPOQGeneProductENSG00000181092 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450
ADIPOR1GeneProductENSG00000159346 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72674
ADIPOR2GeneProductENSG00000006831 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68465
Acetyl-CoAMetabolite15351 (ChEBI)
CPT1AGeneProductENSG00000110090 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894
Fatty acidMetaboliteCHEBI:35366 (ChEBI)
LEPGeneProductENSG00000174697 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16846
LEPRGeneProductENSG00000116678 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847
Malonyl-CoAMetabolite15531 (ChEBI)
PRKAA1GeneProductENSG00000132356 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105787
PRKAB1GeneProductENSG00000111725 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19079
PRKAG1GeneProductENSG00000181929 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19082

Annotated Interactions

No annotated interactions
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