Vitamin D-sensitive calcium signaling in depression (Homo sapiens)

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ER1RXRinflammatory cytokinesCalcium pump2xRXR typesHyperpolarizationPMCA isoformsOpenInsP3R typesNMDA receptor subunitsdemethylasesDepressionHepatocyteNeuronSkinSunlightRXRGRXRBRXRAATP2B4GGTATP2B3ITPR3G6PDKDM1BGSRGPXCHRM1KDM3AGCLCTPH2GRIN2BKDM6BGRIN2DITPR1CalbindinATP2B2Inositol 1,4,5-trisphosphatePVALBKetamineGRIN2CVitamin D pathwayTPH1GRIN1KDM1AITPR2ATP2B1CYP27A1GRM5GRIN2ADiacylglycerolglutamateInsP3RVDREPLCAcetylcholineKCNQ2PIP2VDRH2O2KCNQ3SLC8A1Na+superoxide25(OH)D3Vitamin D3K+BCL2Ca2+LITHIUM IONVitamin D3NMDA receptor7-DehydrocholesterolCYP27B11,25-(OH)2D3VDR target genesCalbindinNFE2L2CACNA1CPMCAAntioxidant genesARECa2+Ca2+SLC8A1PMCACa2+KCNQ2KCNQ3ShutDepolarizationM-currentCACNA1CVDRNFE2L2Ca2+2x


Description

Vitamin D-sensitive calcium signaling in depression

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Quality Tags

Ontology Terms

 

Bibliography

  1. Xuan Qin, Xin Wang; ''Role of vitamin D receptor in the regulation of CYP3A gene expression''; Acta Pharmaceutica Sinica B, 2019 PubMed Europe PMC Scholia
  2. Berridge MJ; ''Vitamin D and Depression: Cellular and Regulatory Mechanisms.''; Pharmacol Rev, 2017 PubMed Europe PMC Scholia
  3. Gong D, Chi X, Ren K, Huang G, Zhou G, Yan N, Lei J, Zhou Q; ''Structure of the human plasma membrane Ca(2+)-ATPase 1 in complex with its obligatory subunit neuroplastin.''; Nat Commun, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142384view16:39, 30 January 2026DeSlChanged inflammatory Cytokine type from Metabolite to GeneProduct
142383view16:37, 30 January 2026DeSlAdded missing annotation and lit ref for PMCA complex
140518view05:56, 6 September 2025EgonwMore unicode and mim-translocation
139937view09:23, 12 July 2025EgonwMore unicode
136779view00:31, 21 February 2025EweitzRefine cell type label placement
136778view00:30, 21 February 2025EweitzStandardize case, refine z-index, align nodes
136777view00:22, 21 February 2025EweitzEconomize layout
136776view13:59, 20 February 2025EweitzOntology Term : 'neuron' added !
136775view13:58, 20 February 2025EweitzOntology Term : 'hepatocyte' added !
136774view13:58, 20 February 2025EweitzOntology Term : 'epidermal cell' added !
136773view13:56, 20 February 2025EweitzLabel organelles
136772view13:51, 20 February 2025EweitzStandardize case
136771view13:51, 20 February 2025EweitzMove label closer
136770view13:50, 20 February 2025EweitzRefine padding, "NMDA receptor" labeling
136769view13:50, 20 February 2025EweitzRefine alignment, fill color
136768view13:46, 20 February 2025EweitzConnect to sunlight
136767view13:46, 20 February 2025EweitzRefine z-index layering
136766view13:42, 20 February 2025EweitzEconomize layout
136765view13:35, 20 February 2025EweitzRefine cell, metabolite placement
136764view13:33, 20 February 2025EweitzUpgrade nodes for sunlight and depression
136763view13:26, 20 February 2025EweitzEconomize layout
136762view13:17, 20 February 2025EweitzEconomize layout
136761view13:04, 20 February 2025EweitzEconomize layout
136760view12:56, 20 February 2025EweitzEconomize layout
136759view12:54, 20 February 2025EweitzTailor node heights
136758view12:51, 20 February 2025EweitzEconomize layout
136757view12:42, 20 February 2025EweitzImprove readability of cell type labels
136756view12:38, 20 February 2025EweitzEconomize layout
136755view12:36, 20 February 2025EweitzEconomize layout
136754view12:33, 20 February 2025EweitzEconomize layout
134350view05:37, 21 July 2024EgonwRemoved a template comment
123493view04:50, 29 July 2022EgonwMade a pathway clickable
119119view08:49, 18 June 2021FinterlyAdded PMID
110708view14:35, 28 May 2020Marvin M2changed unknown datanodes to labels
107972view13:34, 18 November 2019Fehrhartchanged connections to grahpical lines
107718view09:14, 31 October 2019Leonievdvenchanged label into correct metabolites
107717view09:10, 31 October 2019LeonievdvenConnected lines to nodes
107487view14:26, 14 October 2019LeonievdvenChanged visual elements, added complexes
107441view12:12, 8 October 2019LeonievdvenAdded groups/complexes and changed labels into properly annotated genes
107319view11:04, 23 September 2019EgonwInsP3R is a metabolite
106811view13:29, 17 September 2019MaintBotHMDB identifier normalization
106613view07:38, 12 September 2019LeonievdvenChanged secondary ChEBI identifiers to primary identifiers
106611view12:43, 11 September 2019Marvin M2Ontology Term : 'mental depression' added !
106610view12:38, 11 September 2019Marvin M2Ontology Term : 'altered calcium/calcium-mediated signaling pathway' added !
106565view15:06, 6 September 2019LeonievdvenModified description
106564view15:05, 6 September 2019LeonievdvenModified title
106563view15:04, 6 September 2019LeonievdvenModified description
106562view15:02, 6 September 2019LeonievdvenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,25-(OH)2D3MetaboliteHMDB0000876 (HMDB)
25(OH)D3 MetaboliteHMDB0003550 (HMDB)
7-DehydrocholesterolMetaboliteCHEBI:3658 (ChEBI)
ARE
ATP2B1GeneProductENSG00000070961 (Ensembl)
ATP2B2GeneProductENSG00000157087 (Ensembl)
ATP2B3GeneProductENSG00000067842 (Ensembl)
ATP2B4GeneProductENSG00000058668 (Ensembl)
AcetylcholineMetaboliteCHEBI:2416 (ChEBI)
Antioxidant genesGeneProduct
BCL2GeneProductENSG00000171791 (Ensembl)
CACNA1CGeneProductENSG00000151067 (Ensembl)
CHRM1GeneProductENSG00000168539 (Ensembl)
CYP27A1GeneProductENSG00000135929 (Ensembl)
CYP27B1GeneProductENSG00000111012 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
CalbindinProteinP05937 (Uniprot-TrEMBL)
DiacylglycerolMetaboliteCHEBI:4481 (ChEBI)
G6PDGeneProductENSG00000160211 (Ensembl)
GCLCGeneProductENSG00000001084 (Ensembl)
GGTProtein
GPXProteinA0A087WT12 (Uniprot-TrEMBL)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductGRIN2A (HGNC)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductGRIN2C (HGNC)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GRM5GeneProductENSG00000168959 (Ensembl) Type your comment here
GSRGeneProductENSG00000104687 (Ensembl)
H2O2MetaboliteCHEBI:16240 (ChEBI)
ITPR1GeneProductENSG00000150995 (Ensembl)
ITPR2GeneProductENSG00000123104 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
Inositol 1,4,5-trisphosphateMetaboliteHMDB01498 (HMDB)
InsP3RGeneProductCHEBI:16595 (ChEBI)
K+MetaboliteCHEBI:8345 (ChEBI)
KCNQ2GeneProductENSG00000075043 (Ensembl)
KCNQ3GeneProductENSG00000184156 (Ensembl)
KDM1AGeneProductENSG00000004487 (Ensembl)
KDM1BGeneProductENSG00000165097 (Ensembl)
KDM3AGeneProductENSG00000115548 (Ensembl)
KDM6BGeneProductENSG00000132510 (Ensembl)
KetamineMetaboliteHMDB15352 (HMDB)
LITHIUM IONMetaboliteCHEBI:49711 (ChEBI)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NMDA receptorGeneProduct
Na+MetaboliteCHEBI:9175 (ChEBI)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PLCGeneProduct
PMCAComplex
PVALBGeneProductENSG00000100362 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
RXRBGeneProductENSG00000204231 (Ensembl)
RXRGGeneProductENSG00000143171 (Ensembl)
SLC8A1GeneProductENSG00000183023 (Ensembl)
TPH1GeneProductENSG00000129167 (Ensembl)
TPH2GeneProductENSG00000139287 (Ensembl)
VDR target genesGeneProduct
VDRE
VDRGeneProductENSG00000111424 (Ensembl)
Vitamin D pathwayPathwayWP2877 (WikiPathways)
Vitamin D3MetaboliteCHEBI:10008 (ChEBI)
Vitamin D3MetaboliteHMDB0000876 (HMDB)
glutamateMetaboliteCHEBI:14321 (ChEBI)
superoxideMetaboliteCHEBI:18421 (ChEBI)

Annotated Interactions

No annotated interactions

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