Non-homologous end joining (Homo sapiens)

From WikiPathways

Revision as of 05:54, 8 August 2019 by Khanspers (Talk | contribs)
Jump to: navigation, search
XRCC4Nbs1 ?Ku70Ku70XLFRAD50Ku80Ku80DNA-PKcsKu70Ku80Ku80DNA-PKcsKu80Ku70MRE11AKu70Ku70Ku80Ligase VKu80XRCC4Ku80DNA-PKcsKu70DNA-PKcsKu80DNA-PKcsKu70Ku80DNA-PKcsDNA-PKcsLigase VKu70NHEJ1Ku70DNA-PKcs


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells. This pathway is part the CPTAC Assay Portal.

Please use the New WikiPathways

View approved pathways at the new wikipathways.org. This website will shutdown soon.

Quality Tags

Ontology Terms

 

Bibliography

  1. Wyman C, Kanaar R; ''DNA double-strand break repair: all's well that ends well.''; Annu Rev Genet, 2006 PubMed Europe PMC Scholia
  2. ''KEGG''; https://www.genome.jp/dbget-bin/www_bget?pathway+hsa03450,
  3. ''REPAIRtoire Nonhomologous end-joining''; REPAIRtoire,

History

View all...
CompareRevisionActionTimeUserComment
137260view13:34, 1 March 2025EgonwModified description
136389view01:43, 1 February 2025KhanspersModified description
136388view01:42, 1 February 2025Khanspersupdated reference
127652view23:18, 13 November 2023Khanspersadded id and db for repairtoire lit ref
125302view17:43, 31 January 2023LarsgwFix reference
119305view13:08, 23 June 2021Finterlyadded KEGG biopax information
108414view00:07, 18 December 2019KhanspersAdded WRN and removed DNTT
108413view23:29, 17 December 2019Khanspersadded alternative processing steps based on REPAIRtoire
108412view23:12, 17 December 2019Khansperschanged complex and label
108052view00:48, 27 November 2019Khanspersadded references
108051view00:46, 27 November 2019KhanspersModified description
108045view20:22, 26 November 2019KhanspersOntology Term : 'DNA repair pathway' added !
108042view20:21, 26 November 2019Khansperschanged style and graphics
108035view16:09, 25 November 2019Khanspersremoved HR part
108033view07:13, 25 November 2019Khanspersoverhaul in progress
107721view12:24, 31 October 2019DeSlAdded steps to the left, added lit. ref.
107720view12:16, 31 October 2019DeSlChanged blue+black lines to graphical interactions.
107719view12:10, 31 October 2019DeSlChanged unconnected arrows to graphical lines.
107554view23:46, 19 October 2019AlexanderPicoModified description
105501view05:54, 8 August 2019KhanspersModified description
80022view20:57, 30 April 2015ZariCorrected Ensembl ID for DNA-PKcs
68977view17:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
59183view18:51, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45348view20:25, 7 October 2011KhanspersOntology Term : 'DOID:0014667' removed !
45346view20:25, 7 October 2011KhanspersOntology Term : 'non-homologous end joining pathway of double-strand break repair' added !
41150view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
39394view19:04, 20 November 2010Chetan1Ontology Term : 'disease of metabolism' added !
35395view09:48, 12 February 2010MartijnVanIerselModified description
32098view13:44, 14 August 2009MaintBotFixed group labels
29612view12:10, 23 May 2009MartijnVanIerselUpdated ensembl references
22671view14:58, 14 November 2008Thomascapitalized title
21602view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:non-homologous end joining]] moved to [[Pathway:WP438]]: Moved to stable identifier
15846view19:46, 5 June 2008KhanspersAdded gene IDs
14981view19:57, 24 May 2008AlexanderPicoGrouped and connected
9596view11:40, 9 January 2008Thomasadded to cellular process category
9588view10:18, 9 January 2008Thomasadded gene identifiers
9583view09:46, 9 January 2008Thomasmade a start with NHEJ pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DNA-PKcsGeneProductENSG00000253729 (Ensembl)
Ku70GeneProductENSG00000196419 (Ensembl)
Ku80GeneProductENSG00000079246 (Ensembl)
Ligase VGeneProduct
MRE11AGeneProductENSG00000020922 (Ensembl)
NHEJ1GeneProductENSG00000187736 (Ensembl)
Nbs1 ?GeneProduct
RAD50GeneProductENSG00000113522 (Ensembl)
XLFGeneProduct79840 (Entrez Gene)
XRCC4GeneProductENSG00000152422 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP438"
Personal tools