Cysteine and methionine catabolism (Homo sapiens)

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12MTMPSTCystathionine gamma-lyaseAATAspartate aminotransferaseBetainealpha-KBTetra-hydrofolateHomocysteineS-Adenosylmethionine3-Mercaptopyruvic acidGluTaurineCSEH2SCystineS-sulfocysteineSAAHCO2SulfateGlutathioneCysteine sulfinic acidSulfiteB-Sulfinyl pyruvateMATMSserineCysteine dioxygenase type 1ATPCysteine5-MethyltetrahydrofolateS-AdenosylhomocysteinePyrDimethylglycineCystathionineGlutathione synthetaseSulfite oxidaseMethionineCSDHypotaurine-CH3BHMTKGGlutamate-cysteine ligasegamma-GlutamylcysteineHydrogen sulfideAdenosineNH3CSEKGGlu


Description

This pathway visualises the conversion of methionine to cysteine, after which it is further metabolised in either an oxidative or non-oxidative manner. This pathway was inspired by Chapter 12 of the book of Blau (ISBN 978-3-642-40337-8).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Nenad Blau, Marinus Duran, K Michael Gibson, Carlo Dionisi-Vici; '''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''; Springer-Verlag Berlin Heidelberg, 2014
  2. Miyamoto R, Otsuguro K, Yamaguchi S, Ito S; ''Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons.''; J Neurochem, 2014 PubMed Europe PMC Scholia
  3. Smith AE, Matthews RG; ''Protonation state of methyltetrahydrofolate in a binary complex with cobalamin-dependent methionine synthase.''; Biochemistry, 2000 PubMed Europe PMC Scholia
  4. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML; ''Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.''; Nat Struct Biol, 2002 PubMed Europe PMC Scholia
  5. Castro C, Gratson AA, Evans JC, Jiracek J, Collinsová M, Ludwig ML, Garrow TA; ''Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis.''; Biochemistry, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140762view12:22, 25 October 2025EgonwNH₄⁺ with unicode
140449view05:48, 25 August 2025EgonwMore unicode
139561view07:07, 21 June 2025EgonwWater with unicode
137928view18:28, 10 March 2025KhanspersModified description
134763view00:31, 27 July 2024EweitzFlush cache for board dimension
134762view00:29, 27 July 2024EweitzEconomize layout, align nodes
134756view00:05, 27 July 2024EweitzOntology Term : 'amino acid metabolic pathway' added !
134755view00:04, 27 July 2024EweitzModified description
134754view00:03, 27 July 2024EweitzOmit shape in unclickable pathway, standardize case
119316view13:19, 23 June 2021FinterlyAdded ISBN for book citation
108080view11:48, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
107384view13:48, 3 October 2019DdomingofAdd thiosulfate(2−) info
106801view13:28, 17 September 2019MaintBotHMDB identifier normalization
104395view14:15, 23 May 2019IreneHemelAdded more Rhea IDs
104394view13:59, 23 May 2019IreneHemelAdded Rhea IDs
104241view15:16, 11 May 2019MaintBotRemoved the RHEA: prefix from the identifier.
104174view16:12, 8 May 2019DeSlAdded Rhea IDs for reactions from homocysteine to methionine
104173view15:50, 8 May 2019DeSlMade blue arrows smaller, for better visualisation on website.
104017view15:29, 25 April 2019IreneHemelModified description
104013view15:28, 25 April 2019IreneHemelAdded more Rhea IDs
104012view15:18, 25 April 2019IreneHemelAdded more Rhea IDs
104009view14:28, 25 April 2019IreneHemelAdded Rhea IDs and correct CHEBI or Uniprot IDs for several reactions
102835view20:44, 24 January 2019EgonwReplaced secondary ChEBI IDs with primary IDs.
102826view15:47, 24 January 2019DeSlModified description
102812view15:19, 24 January 2019DeSlAnother small layout change
102811view15:18, 24 January 2019DeSlChanged layout
102810view15:17, 24 January 2019DeSlChanged Enzyme nomenclature ID to Uniprot for SO
102799view13:57, 24 January 2019DeSlOntology Term : 'methionine degradation pathway' added !
102798view13:56, 24 January 2019DeSlOntology Term : 'methionine cycle/metabolic pathway' added !
102797view13:56, 24 January 2019DeSlOntology Term : 'cysteine metabolic pathway' added !
102796view13:56, 24 January 2019DeSlOntology Term : 'cysteine and methionine metabolic pathway' added !
102795view13:54, 24 January 2019DeSlModified description
102794view13:52, 24 January 2019DeSlAdded in- and decreased metabolites related to MoCD.
102793view13:48, 24 January 2019DeSlAnnotated RSSH
102791view13:44, 24 January 2019DeSlChanged layout according to lit. ref
102790view13:40, 24 January 2019DeSlAnnotated several proteins (bottom)
102789view13:34, 24 January 2019DeSlLayout update
102788view13:33, 24 January 2019DeSlUpdated other missing reactions
102786view12:02, 24 January 2019DeSlAdded more side metabolites
102785view10:53, 24 January 2019DeSlmore layout changes, added side metabolites to left bottom side of PW.
102784view10:31, 24 January 2019DeSlChanged layout top, annotated side metabolites top
102749view07:16, 23 January 2019EgonwReplaced secondary ChEBI IDs with primary IDs.
102747view13:35, 22 January 2019DeSlAdded several side metabolites, and lit. ref.
102741view16:36, 21 January 2019DeSlModified description
102740view16:34, 21 January 2019DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
-CH3MetaboliteCHEBI:25251 (ChEBI)
3-Mercaptopyruvic acidMetaboliteCHEBI:16208 (ChEBI)
5-Methyl tetrahydrofolateMetaboliteCHEBI:15641 (ChEBI)
AATProteinA0A140VK69 (Uniprot-TrEMBL) AKA Aspartate aminotransferase
ATPMetaboliteCHEBI:2359 (ChEBI)
AdenosineMetaboliteCHEBI:2472 (ChEBI)
Aspartate aminotransferaseProteinA0A140VK69 (Uniprot-TrEMBL)
B-Sulfinyl pyruvateMetaboliteHMDB02332 (HMDB)
BHMTProteinE5RJH0 (Uniprot-TrEMBL) AKA Betaine--homocysteine S-methyltransferase 1
BetaineMetaboliteCHEBI:17750 (ChEBI)
CO2MetaboliteCHEBI:3283 (ChEBI)
CSDProteinF8WCW3 (Uniprot-TrEMBL) AKA Cysteine sulfinic acid decarboxylase
CSEProteinP35520 (Uniprot-TrEMBL) aka Cystathionine beta-synthase
Cystathionine gamma-lyaseProteinP32929 (Uniprot-TrEMBL)
CystathionineMetaboliteCHEBI:17482 (ChEBI)
Cysteine dioxygenase type 1ProteinQ16878 (Uniprot-TrEMBL)
Cysteine sulfinic acid MetaboliteCHEBI:61085 (ChEBI)
CysteineMetaboliteCHEBI:15356 (ChEBI)
CystineMetaboliteCHEBI:17376 (ChEBI)
DimethylglycineMetaboliteHMDB00092 (HMDB)
GluMetaboliteCHEBI:28300 (ChEBI) AKA glutamine
Glutamate-cysteine ligaseProteinQ14TF0 (Uniprot-TrEMBL)
Glutathione synthetaseProteinP48637 (Uniprot-TrEMBL)
GlutathioneMetaboliteCHEBI:16856 (ChEBI)
H2SMetaboliteCHEBI:16136 (ChEBI) aka Hydrogen sulfide
HomocysteineMetaboliteCHEBI:17230 (ChEBI)
Hydrogen sulfideMetaboliteCHEBI:16136 (ChEBI)
HypotaurineMetaboliteCHEBI:16668 (ChEBI)
KGMetaboliteCHEBI:16810 (ChEBI) aka a-ketoglutarate (a-KG)
MATGeneProduct2.5.1.6 (BRENDA) aka Methionine adenosyltransferase
MPSTProteinP25325 (Uniprot-TrEMBL) AKA 3-mercaptopyruvate sulfurtransferase
MSProteinQ99707 (Uniprot-TrEMBL) AKA Methionine synthase
MTGeneProduct2.1.1 (BRENDA) AKA Methyltransferase
MethionineMetaboliteCHEBI:16643 (ChEBI)
NH3MetaboliteCHEBI:13406 (ChEBI)
PyrMetaboliteCHEBI:32816 (ChEBI) AKA Pyruvic acid
S-AdenosylhomocysteineMetaboliteCHEBI:16680 (ChEBI)
S-AdenosylmethionineMetaboliteCHEBI:67040 (ChEBI)
S-sulfocysteineMetaboliteCHEBI:27891 (ChEBI)
SAAHProteinA0A024R0A8 (Uniprot-TrEMBL) Adenosylhomocysteinase
SulfateMetaboliteHMDB01448 (HMDB)
Sulfite oxidaseGeneProduct1.8.3.1 (BRENDA)
SulfiteMetaboliteCHEBI:26823 (ChEBI)
TaurineMetaboliteCHEBI:15891 (ChEBI)
Tetra- hydrofolateMetaboliteCHEBI:20506 (ChEBI)
alpha-KBMetabolite
gamma-GlutamylcysteineMetaboliteCHEBI:17515 (ChEBI)
serineMetaboliteCHEBI:17822 (ChEBI)

Annotated Interactions

No annotated interactions

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