Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)

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88888888288888888811888888888888888888endoplasmic reticulum membraneextracellular exosomenucleoplasmmitochondrial matrixsecretory granule lumencytosolcell junctionazurophil granule membranecytoplasmic vesicle membraneMSNTALDO1ANXA2MTAPTALDO1 geneSOD1LCP1CDC42 geneGSTO1SNRPA1 geneMTAP geneARF1Y963-STAT4 dimerHNRNPDL genePSME2ANXA2 geneCAPZA1 genePPIAMSN geneIL10 genep-Y693-STAT4 LMNB1AIPARF1 geneCAPZA1CDC42RAPB1 geneBOLA2 genePDCD4 geneAIP geneBOLA2HNRNPA2B1IFNG geneCA1SOD1 geneHNRNPA2B1 geneSOD2GSTA2 genePITPNACNN2IL10TCP1 genePSME2 geneTCP1LMNB1 geneSERPINB2IFNGSNRPA1PITPNA genePAK2GSTO1 geneCNN2 geneLCP1 geneRPLP0 genePAK2 geneRPLP0CFL1MIFPPIA geneCFL1 geneGSTA2HSP9 geneMIF geneHNRNPDLHNRNPF genep-S43,S173,S294,S325-FOXO3RAP1BCA1 geneSERPINB2 geneHNRNPFRALA geneGGC-RALASOD2 genePDCD4HSPA99, 13538, 10766121884, 148


Description

Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). 
The identified upregulated proteins are:  BOLA2, PSME2,  MTAP, CA1,  GSTA2,  RALA,  CNN2,  CFL1,  TCP1,  HNRNPDL,  MIF,  AIP,  SOD1, PPIA and  PDCD4.
And the identified downregulated proteins are:
ANXA2, RPLP0, CAPZA1, SOD2, SNRPA1, LMNB1, LCP1, HSPA9, SERPINB2, HNRNPF, TALDO1, PAK2, TCP1, HNRNPA2B1, MSN, PITPNA, ARF1, SOD2, ANXA2, CDC42, RAP1B and GSTO1.
View original pathway at:Reactome.

Comments

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Pathway is converted from Reactome ID: 8950505
Reactome-version 
Reactome version: 65
Reactome Author 
Reactome Author: Duenas, Corina

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Bibliography

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  1. Verhoeven NM, Huck JH, Roos B, Struys EA, Salomons GS, Douwes AC, van der Knaap MS, Jakobs C.; ''Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway.''; PubMed Europe PMC Scholia
  2. Wispé JR, Clark JC, Burhans MS, Kropp KE, Korfhagen TR, Whitsett JA.; ''Synthesis and processing of the precursor for human mangano-superoxide dismutase.''; PubMed Europe PMC Scholia
  3. Naeger LK, McKinney J, Salvekar A, Hoey T.; ''Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling.''; PubMed Europe PMC Scholia
  4. Higgins CM, Jung C, Ding H, Xu Z.; ''Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS.''; PubMed Europe PMC Scholia
  5. Rosengren AT, Nyman TA, Lahesmaa R.; ''Proteome profiling of interleukin-12 treated human T helper cells.''; PubMed Europe PMC Scholia
  6. Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S.; ''Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.''; PubMed Europe PMC Scholia
  7. Kienhöfer J, Häussler DJ, Ruckelshausen F, Muessig E, Weber K, Pimentel D, Ullrich V, Bürkle A, Bachschmid MM.; ''Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents.''; PubMed Europe PMC Scholia
  8. Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR.; ''In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.''; PubMed Europe PMC Scholia
  9. Banci L, Camponeschi F, Ciofi-Baffoni S, Muzzioli R.; ''Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway.''; PubMed Europe PMC Scholia
  10. Wabnitz GH, Köcher T, Lohneis P, Stober C, Konstandin MH, Funk B, Sester U, Wilm M, Klemke M, Samstag Y.; ''Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25.''; PubMed Europe PMC Scholia
  11. Zakharyan RA, Sampayo-Reyes A, Healy SM, Tsaprailis G, Board PG, Liebler DC, Aposhian HV.; ''Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily.''; PubMed Europe PMC Scholia
  12. He C, Murthy S, McCormick ML, Spitz DR, Ryan AJ, Carter AB.; ''Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation.''; PubMed Europe PMC Scholia
  13. Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA.; ''Defining the membrane proteome of NK cells.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114696view16:17, 25 January 2021ReactomeTeamReactome version 75
113141view11:20, 2 November 2020ReactomeTeamReactome version 74
112371view15:30, 9 October 2020ReactomeTeamReactome version 73
101274view11:16, 1 November 2018ReactomeTeamreactome version 66
100812view20:46, 31 October 2018ReactomeTeamreactome version 65
100353view19:22, 31 October 2018ReactomeTeamreactome version 64
99898view16:05, 31 October 2018ReactomeTeamreactome version 63
99455view14:38, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99119view12:40, 31 October 2018ReactomeTeamreactome version 62
93536view11:26, 9 August 2017ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AIP geneGeneProductENSG00000110711 (Ensembl)
AIPProteinO00170 (Uniprot-TrEMBL)
ANXA2 geneGeneProductENSG00000182718 (Ensembl)
ANXA2ProteinP07355 (Uniprot-TrEMBL)
ARF1 geneGeneProductENSG00000143761 (Ensembl)
ARF1ProteinP84077 (Uniprot-TrEMBL)
BOLA2 geneGeneProductENSG00000183336 (Ensembl)
BOLA2ProteinQ9H3K6 (Uniprot-TrEMBL)
CA1 geneGeneProductENSG00000133742 (Ensembl)
CA1ProteinP00915 (Uniprot-TrEMBL)
CAPZA1 geneGeneProductENSG00000116489 (Ensembl)
CAPZA1ProteinP52907 (Uniprot-TrEMBL)
CDC42 geneGeneProductENSG00000070831 (Ensembl)
CDC42ProteinP60953 (Uniprot-TrEMBL)
CFL1 geneGeneProductENSG00000172757 (Ensembl)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CNN2 geneGeneProductENSG00000064666 (Ensembl)
CNN2ProteinQ99439 (Uniprot-TrEMBL)
GGC-RALAProteinP11233 (Uniprot-TrEMBL)
GSTA2 geneGeneProductENSG00000244067 (Ensembl)
GSTA2ProteinP09210 (Uniprot-TrEMBL)
GSTO1 geneGeneProductENSG00000148834 (Ensembl)
GSTO1ProteinP78417 (Uniprot-TrEMBL)
HNRNPA2B1 geneGeneProductENSG00000122566 (Ensembl)
HNRNPA2B1ProteinP22626 (Uniprot-TrEMBL)
HNRNPDL geneGeneProductENSG00000152795 (Ensembl)
HNRNPDLProteinO14979 (Uniprot-TrEMBL)
HNRNPF geneGeneProductENSG00000169813 (Ensembl)
HNRNPFProteinP52597 (Uniprot-TrEMBL)
HSP9 geneGeneProductENSG00000113013 (Ensembl)
HSPA9ProteinP38646 (Uniprot-TrEMBL)
IFNG geneGeneProductENSG00000111537 (Ensembl)
IFNGProteinP01579 (Uniprot-TrEMBL)
IL10 geneGeneProductENSG00000136634 (Ensembl)
IL10ProteinP22301 (Uniprot-TrEMBL)
LCP1 geneGeneProductENSG00000136167 (Ensembl)
LCP1ProteinP13796 (Uniprot-TrEMBL)
LMNB1 geneGeneProductENSG00000113368 (Ensembl)
LMNB1ProteinP20700 (Uniprot-TrEMBL)
MIF geneGeneProductENSG00000240972 (Ensembl)
MIFProteinP14174 (Uniprot-TrEMBL)
MSN geneGeneProductENSG00000147065 (Ensembl)
MSNProteinP26038 (Uniprot-TrEMBL)
MTAP geneGeneProductENSG00000099810 (Ensembl)
MTAPProteinQ13126 (Uniprot-TrEMBL)
PAK2 geneGeneProductENSG00000180370 (Ensembl)
PAK2ProteinQ13177 (Uniprot-TrEMBL)
PDCD4 geneGeneProductENSG00000150593 (Ensembl)
PDCD4ProteinQ53EL6 (Uniprot-TrEMBL)
PITPNA geneGeneProductENSG00000174238 (Ensembl)
PITPNAProteinQ00169 (Uniprot-TrEMBL)
PPIA geneGeneProductENSG00000196262 (Ensembl)
PPIAProteinP62937 (Uniprot-TrEMBL)
PSME2 geneGeneProductENSG00000100911 (Ensembl)
PSME2ProteinQ9UL46 (Uniprot-TrEMBL)
RALA geneGeneProductENSG00000006451 (Ensembl)
RAP1BProteinP61224 (Uniprot-TrEMBL)
RAPB1 geneGeneProductENSG00000127314 (Ensembl)
RPLP0 geneGeneProductENSG00000089157 (Ensembl)
RPLP0ProteinP05388 (Uniprot-TrEMBL)
SERPINB2 geneGeneProductENSG00000197632 (Ensembl)
SERPINB2ProteinP05120 (Uniprot-TrEMBL)
SNRPA1 geneGeneProductENSG00000131876 (Ensembl)
SNRPA1ProteinP09661 (Uniprot-TrEMBL)
SOD1 geneGeneProductENSG00000142168 (Ensembl)
SOD1ProteinP00441 (Uniprot-TrEMBL)
SOD2 geneGeneProductENSG00000112096 (Ensembl)
SOD2ProteinP04179 (Uniprot-TrEMBL)
TALDO1 geneGeneProductENSG00000177156 (Ensembl)
TALDO1ProteinP37837 (Uniprot-TrEMBL)
TCP1 geneGeneProductENSG00000120438 (Ensembl)
TCP1ProteinP17987 (Uniprot-TrEMBL)
Y963-STAT4 dimerComplexR-HSA-8950759 (Reactome)
p-S43,S173,S294,S325-FOXO3ProteinO43524 (Uniprot-TrEMBL)
p-Y693-STAT4 ProteinQ14765 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
AIP geneR-HSA-8950201 (Reactome)
AIPArrowR-HSA-8950201 (Reactome)
ANXA2 geneR-HSA-8950480 (Reactome)
ANXA2ArrowR-HSA-8950480 (Reactome)
ARF1 geneR-HSA-8950173 (Reactome)
ARF1ArrowR-HSA-8950173 (Reactome)
BOLA2 geneR-HSA-8950344 (Reactome)
BOLA2ArrowR-HSA-8950344 (Reactome)
CA1 geneR-HSA-8950623 (Reactome)
CA1ArrowR-HSA-8950623 (Reactome)
CAPZA1 geneR-HSA-8950634 (Reactome)
CAPZA1ArrowR-HSA-8950634 (Reactome)
CDC42 geneR-HSA-8950637 (Reactome)
CDC42ArrowR-HSA-8950637 (Reactome)
CFL1 geneR-HSA-8950581 (Reactome)
CFL1ArrowR-HSA-8950581 (Reactome)
CNN2 geneR-HSA-8950314 (Reactome)
CNN2ArrowR-HSA-8950314 (Reactome)
GGC-RALAArrowR-HSA-8950533 (Reactome)
GSTA2 geneR-HSA-8950586 (Reactome)
GSTA2ArrowR-HSA-8950586 (Reactome)
GSTO1 geneR-HSA-8950175 (Reactome)
GSTO1ArrowR-HSA-8950175 (Reactome)
HNRNPA2B1 geneR-HSA-8950292 (Reactome)
HNRNPA2B1ArrowR-HSA-8950292 (Reactome)
HNRNPDL geneR-HSA-8950684 (Reactome)
HNRNPDLArrowR-HSA-8950684 (Reactome)
HNRNPF geneR-HSA-8950415 (Reactome)
HNRNPFArrowR-HSA-8950415 (Reactome)
HSP9 geneR-HSA-8950389 (Reactome)
HSPA9ArrowR-HSA-8950389 (Reactome)
IFNG geneR-HSA-9006431 (Reactome)
IFNGArrowR-HSA-9006431 (Reactome)
IL10 geneR-HSA-8981073 (Reactome)
IL10ArrowR-HSA-8981073 (Reactome)
LCP1 geneR-HSA-8950426 (Reactome)
LCP1ArrowR-HSA-8950426 (Reactome)
LMNB1 geneR-HSA-8950681 (Reactome)
LMNB1ArrowR-HSA-8950681 (Reactome)
MIF geneR-HSA-8950732 (Reactome)
MIFArrowR-HSA-8950732 (Reactome)
MSN geneR-HSA-8950218 (Reactome)
MSNArrowR-HSA-8950218 (Reactome)
MTAP geneR-HSA-8950365 (Reactome)
MTAPArrowR-HSA-8950365 (Reactome)
PAK2 geneR-HSA-8950190 (Reactome)
PAK2ArrowR-HSA-8950190 (Reactome)
PDCD4 geneR-HSA-8950721 (Reactome)
PDCD4ArrowR-HSA-8950721 (Reactome)
PITPNA geneR-HSA-8950213 (Reactome)
PITPNAArrowR-HSA-8950213 (Reactome)
PPIA geneR-HSA-8950328 (Reactome)
PPIAArrowR-HSA-8950328 (Reactome)
PSME2 geneR-HSA-8950260 (Reactome)
PSME2ArrowR-HSA-8950260 (Reactome)
R-HSA-8870703 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Superoxide dismutase [Mn], mitochondrial(SOD2).
R-HSA-8950173 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :ADP-ribosylation factor 1(ARF1).
R-HSA-8950175 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Glutathione S-transferase omega-1(GSTO1)
R-HSA-8950190 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Serine/threonine-protein kinase PAK 2(PAK2).
R-HSA-8950201 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :AH receptor-interacting protein(AIP).
R-HSA-8950213 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Phosphatidylinositol transfer protein alpha isoform(PITPNA).
R-HSA-8950218 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Moesin(MSN).
R-HSA-8950225 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Ras-related protein Rap-1b(RAP1B).
R-HSA-8950260 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Proteasome activator complex subunit 2(PSME2).
R-HSA-8950292 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Heterogeneous nuclear ribonucleoproteins A2/B1(HNRNPA2B1).
R-HSA-8950314 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Calponin-2(CNN2).
R-HSA-8950322 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :60S acidic ribosomal protein P0(RPLP0).
R-HSA-8950328 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Peptidyl-prolyl cis-trans isomerase A(PPIA). This protein is found in four spots, which probably represent four different isoforms.
R-HSA-8950344 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005).Among the up-regulated proteins is :BolA-like protein 2(BOLA2).
R-HSA-8950365 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :S-methyl-5'-thioadenosine phosphorylase(MTAP).
R-HSA-8950367 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Transaldolase(TALDO1).
R-HSA-8950389 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :HSPA9 protein(HSPA9).
R-HSA-8950415 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Heterogeneous nuclear ribonucleoprotein F(HNRNPF).
R-HSA-8950426 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Plastin-2(LCP1).
R-HSA-8950480 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Annexin A2(ANXA2), which is present in two spots probably indicating two different isoforms
R-HSA-8950533 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Ras-related protein Ral-A(RALA).
R-HSA-8950567 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Plasminogen activator inhibitor 2(SERPINB2).
R-HSA-8950581 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Cofilin-1(CFL1).
R-HSA-8950586 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Glutathione S-transferase A2(GSTA2).
R-HSA-8950608 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :U2 small nuclear ribonucleoprotein A' (SNRPA1).
R-HSA-8950623 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Carbonic anhydrase 1(CA1).
R-HSA-8950634 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :F-actin-capping protein subunit alpha-1(CAPZA1).
R-HSA-8950637 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Cell division control protein 42 homolog(CDC42).
R-HSA-8950681 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Lamin-B1(LMNB1).
R-HSA-8950684 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Heterogeneous nuclear ribonucleoprotein D-like(HNRNPDL).
R-HSA-8950718 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the proteins that is identified in more than one spot, which probably is due to different isoforms, is T-complex protein 1 subunit alpha (TCP1), one isoform of this protein is upregulated, the other down-regulated.
R-HSA-8950721 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Programmed cell death protein 4(PDCD4).
R-HSA-8950732 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Macrophage migration inhibitory factor(MIF).
R-HSA-8950771 (Reactome) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Superoxide dismutase [Cu-Zn](SOD1).
R-HSA-8981073 (Reactome) In response to IL-12 normal T cells produce interleukin-10 (IL10) (van de Vosse et al 2005).
R-HSA-9006431 (Reactome) The most important and most analysed IL-12-induced protein is Interferon-gamma (IFNG). In response to IL-12 normal T cells produce interferon-gamma (IFNG) (van de Vosse et al 2005). In PBMCs from subjects that lack the interleukin-12 receptor beta 2 subunit (IL12RB2) no interferon gamma is produced in response to IL-12, while in healthy subjects it is (de Jong et al 1998).

To identify genes induced by IL-12, microarray analysis of over 33.000 genes was conducted using human PBMC enriched for CD3 + T cells after stimulation for 6 h with IL-12. Approximately 90 genes were differentially induced by IL-12 stimulation, of which IFNG was upregulated 24-fold (Watford et al 2008). Expression of IL-12 induced genes was also analysed by a microarray containing 6000 human genes, in differentiated Th1 cells. In these cells IL-12 induced a 53-fold upregulation of IFNG (Rogge et al 2000)

Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005).
RALA geneR-HSA-8950533 (Reactome)
RAP1BArrowR-HSA-8950225 (Reactome)
RAPB1 geneR-HSA-8950225 (Reactome)
RPLP0 geneR-HSA-8950322 (Reactome)
RPLP0ArrowR-HSA-8950322 (Reactome)
SERPINB2 geneR-HSA-8950567 (Reactome)
SERPINB2ArrowR-HSA-8950567 (Reactome)
SNRPA1 geneR-HSA-8950608 (Reactome)
SNRPA1ArrowR-HSA-8950608 (Reactome)
SOD1 geneR-HSA-8950771 (Reactome)
SOD1ArrowR-HSA-8950771 (Reactome)
SOD2 geneR-HSA-8870703 (Reactome)
SOD2ArrowR-HSA-8870703 (Reactome)
TALDO1 geneR-HSA-8950367 (Reactome)
TALDO1ArrowR-HSA-8950367 (Reactome)
TCP1 geneR-HSA-8950718 (Reactome)
TCP1ArrowR-HSA-8950718 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950201 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950260 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950314 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950328 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950344 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950365 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950533 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950581 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950586 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950623 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950684 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950718 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950721 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950732 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8950771 (Reactome)
Y963-STAT4 dimerArrowR-HSA-8981073 (Reactome)
Y963-STAT4 dimerArrowR-HSA-9006431 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8870703 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950173 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950175 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950190 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950213 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950218 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950225 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950292 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950322 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950367 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950389 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950415 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950426 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950480 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950567 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950608 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950634 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950637 (Reactome)
Y963-STAT4 dimerTBarR-HSA-8950681 (Reactome)
p-S43,S173,S294,S325-FOXO3ArrowR-HSA-8870703 (Reactome)
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