Portal:CPTAC

From WikiPathways

Revision as of 17:33, 3 October 2017 by AlexanderPico (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

CPTAC Pathways

Welcome to the CPTAC Pathway Portal

This portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC).

The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public.

The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011.

edit

Pathway Curation

On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.

Getting Started

Introduction to WikiPathways (slides)
WikiPathways Overview or New Contributor Quickstart
General help pages
CPTAC Workshop Exercises

Resources

Learn more about CPTAC
Pathway analysis
- Cytoscape and the WikiPathways app
- PathVisio and the WikiPathways plugin

Curation projects

Curating Hallmark Pathways -- How to
Example: construction of Pathways in Renal Cancer
Contact Alex Pico if interested in curating, adding or using CPTAC pathways, apico@gladstone.ucsf.edu

edit

Cancer Hallmark Categories

Sustaining proliferative signaling Hippo-Merlin signaling dysregulation (Homo sapiens) Image does not exist Hippo-Merlin signaling dysregulation	Evading growth suppressors TGF-beta signaling (Homo sapiens) Image does not exist TGF-beta signaling	Activating invasion and metastasis MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens) Image does not exist MFAP5-mediated ovarian cancer cell motility and invasiveness
Enabling replicative immortality Wnt signaling, NetPath (Homo sapiens) Image does not exist Wnt signaling, NetPath	Inducing angiogenesis Hedgehog signaling (Homo sapiens) Image does not exist Hedgehog signaling	Resisting cell death TP53 network (Homo sapiens) Image does not exist TP53 network
Deregulating cellular energetics Glycolysis and gluconeogenesis (Homo sapiens) Image does not exist Glycolysis and gluconeogenesis	Genome instability and mutation Non-homologous end joining (Homo sapiens) Image does not exist Non-homologous end joining	Tumor promoting inflammation IL1 signaling (Homo sapiens) Image does not exist IL1 signaling
Avoiding immune destruction Altered glycosylation of MUC1 in tumor microenvironment (Homo sapiens) Image does not exist Altered glycosylation of MUC1 in tumor microenvironment	Therapeutics Transcriptional activation by NRF2 in response to phytochemicals (Homo sapiens) Image does not exist Transcriptional activation by NRF2 in response to phytochemicals