Prion disease pathway (Homo sapiens)

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1?Neuronal apoptosis1FGFR1PTK2PrPScPRNP (+ mutations)PrP Receptor ?FYNCREB1PDIA3ELK1Ac-DEVD-fmkBCL2-ERPrPCCa2+NCAM1MAPK1MAPK3CASP12-DNPRNP (+ mutations)NFKB1HSP90B1PRNPHSPA5PRO CASP12CASP3CASP12111111111FYNPTK2PP


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C; ''Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.''; EMBO J, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140058view07:46, 21 July 2025EgonwCalcium ion with unicode
137666view20:01, 6 March 2025KhanspersModified description
129475view03:22, 24 April 2024EweitzOntology Term : 'CL:0000540' removed !
128423view17:46, 4 February 2024EweitzEconomize layout
128402view04:16, 4 February 2024EweitzUse same height for altered-state PRNP nodes
128401view04:15, 4 February 2024EweitzUse same height for single-line nodes
128395view03:24, 4 February 2024EweitzOntology Term : 'CL:0000540' removed !
128394view03:23, 4 February 2024EweitzUpgrade pathway node, note cell type
128393view03:19, 4 February 2024EweitzRefine z-index, positions
128392view03:14, 4 February 2024EweitzEconomize layout, standardize case
127628view21:53, 9 November 2023Khanspersmoved link to WP1866 from literature reference to node comment
119304view13:06, 23 June 2021Finterlyadded WPID to PublicationXref
108089view11:55, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
106531view23:51, 5 September 2019KhanspersModified description
105792view19:49, 15 August 2019KhanspersModified description
104288view12:48, 15 May 2019FehrhartOntology Term : 'CL:0000540' removed !
96400view10:15, 12 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
94740view15:08, 5 October 2017Mkutmonfix unconnected line
93157view14:41, 1 August 2017FehrhartRe-added Z-DEVD-FMK after being added to ChEBI
93045view09:03, 27 July 2017FehrhartConnected interactions
92788view12:26, 6 July 2017LvdWouwModified description
92787view12:09, 6 July 2017LvdWouw
92775view08:31, 4 July 2017LvdWouw
92774view08:03, 4 July 2017LvdWouw
92752view12:01, 3 July 2017LvdWouwAdded PRNP regulators from ENCODE
92750view06:14, 3 July 2017FehrhartOntology Term : 'neuron' added !
92749view06:12, 3 July 2017FehrhartOntology Term : 'prion disease' added !
92720view08:15, 30 June 2017LvdWouw
92718view07:06, 30 June 2017LvdWouw
92705view09:03, 29 June 2017LvdWouw
92683view17:41, 28 June 2017MaintBotfixed unconnected
92664view16:21, 27 June 2017LvdWouwOntology Term : 'prion diseases pathway' added !
92663view16:21, 27 June 2017LvdWouwOntology Term : 'PW:0000267' removed !
92662view16:20, 27 June 2017LvdWouwOntology Term : 'neuron' added !
92661view16:19, 27 June 2017LvdWouwModified title
92660view16:19, 27 June 2017LvdWouwModified title
92659view16:17, 27 June 2017LvdWouw
92658view16:08, 27 June 2017LvdWouwModified description
92657view16:07, 27 June 2017LvdWouwModified description
92522view10:56, 13 June 2017FehrhartOntology Term : 'fatal familial insomnia pathway' added !
92519view08:12, 13 June 2017LvdWouw
92518view07:52, 13 June 2017LvdWouwAdded state (phosphorylation)
92514view07:56, 12 June 2017LvdWouw
92513view07:56, 12 June 2017LvdWouw
92512view07:47, 12 June 2017LvdWouwModified title
92511view07:47, 12 June 2017LvdWouwModified title
92510view07:47, 12 June 2017LvdWouwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Ac-DEVD-fmk
BCL2-ERGeneProductENSG00000171791 (Ensembl)
CASP12-DNGeneProductENSG00000204403 (Ensembl)
CASP12GeneProductENSG00000204403 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CREB1ProteinENSG00000118260 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
ELK1GeneProductENSG00000126767 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FYNGeneProductENSG00000010810 (Ensembl)
HSP90B1GeneProductENSG00000166598 (Ensembl)
HSPA5GeneProductENSG00000044574 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
NCAM1GeneProductENSG00000149294 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PDIA3GeneProductENSG00000167004 (Ensembl)
PRNP (+ mutations)GeneProductENSG00000171867 (Ensembl)
PRNPGeneProductENSG00000171867 (Ensembl)
PRO CASP12GeneProductENSG00000204403 (Ensembl)
PTK2GeneProductENSG00000169398 (Ensembl)
PrP Receptor ?Protein
PrPCProtein
PrPScProtein

Annotated Interactions

No annotated interactions

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