Hypothesized pathways in pathogenesis of cardiovascular disease (Homo sapiens)

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1Valvular Heart DiseaseCardiomyopathyAortic AneurysmHypertensionAtherosclerosisKawasaki DiseaseTGFB Ligands, Receptors, Activators, EffectorsEndocardial and Epicardial EMT, neural crest migration, ECM remodeling, cell differentiation,development and maintenance of cardiovascular structure and functionTarget Gene ExpressionAT1/2RFibrillinsJNK1SHCACTGFRUNX2PAI-1Endoglinp38ERK1ANG2TGFBR1LTBPsSMAD2PeriostinCalcium Calneurin PathwayTGFBR3SMAD3TGFBR2SMAD4Tak1ERK2


Description

The pathways hypothesized to be involved in cardiovascular diseases begin with LTBPs and Fibrillins activating a TGFBR complex. The complex can begin the canonical TGFB pathway involving SMAD proteins that target gene expression for proteins involved in

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Ontology Terms

 

Bibliography

  1. Doetschman T, Barnett JV, Runyan RB, Camenisch TD, Heimark RL, Granzier HL, Conway SJ, Azhar M; ''Transforming growth factor beta signaling in adult cardiovascular diseases and repair.''; Cell Tissue Res, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142021view13:23, 29 November 2025EweitzClear deprecated metadata rendering
137979view21:14, 10 March 2025KhanspersModified description
136796view01:26, 21 February 2025EweitzFix state position
136795view01:26, 21 February 2025EweitzFix node position
136794view01:25, 21 February 2025EweitzEconomize layout
136793view01:23, 21 February 2025EweitzIncrease font size
136792view01:22, 21 February 2025EweitzEconomize layout
128974view23:45, 25 February 2024EweitzColor biological process nodes with #088, economize layout
128973view23:42, 25 February 2024EweitzVisually distinguish biological process nodes via #077, rounding
128972view23:29, 25 February 2024EweitzNodulize biological processes
128971view23:09, 25 February 2024EweitzModified description
128970view23:02, 25 February 2024EweitzOntology Term : 'endocardial cell' added !
128969view23:00, 25 February 2024EweitzUpgrade disease nodes
128968view22:24, 25 February 2024EweitzOntology Term : 'Kawasaki disease' added !
128967view22:24, 25 February 2024EweitzOntology Term : 'atherosclerosis' added !
128966view22:23, 25 February 2024EweitzOntology Term : 'hypertension' added !
128965view22:23, 25 February 2024EweitzOntology Term : 'aortic aneurysm' added !
128964view22:21, 25 February 2024EweitzOntology Term : 'cardiomyopathy' added !
128963view22:20, 25 February 2024EweitzOntology Term : 'cardiomyopathy pathway' added !
128962view22:20, 25 February 2024EweitzOntology Term : 'heart valve disease' added !
128961view20:03, 25 February 2024EweitzFix invalid pathway node, standardize case
123393view06:23, 23 July 2022EgonwRemoved an "N/A" identifier
117756view12:52, 22 May 2021EweitzModified title
108207view11:12, 29 November 2019FehrhartOntology Term : 'disease pathway' added !
106596view19:35, 10 September 2019KhanspersModified description
105620view04:58, 10 August 2019KhanspersModified description
97639view14:21, 31 May 2018AMTanOntology Term : 'cardiovascular system disease' added !
90185view18:37, 21 October 2016Khanspersfixed unconnected
90100view17:38, 13 October 2016Khanspersupdate
88723view19:15, 12 August 2016AAR&CoAdded Data Nodes
88722view19:06, 12 August 2016AAR&CoPeriodical save, work in progress
88721view18:43, 12 August 2016AAR&CoEdited Interactions and Labels
88720view18:40, 12 August 2016AAR&CoPeriodical save, work in progress
88655view15:13, 12 August 2016JmeliusOntology Term : 'cardiovascular system disease pathway' added !
85961view20:03, 21 June 2016AAR&CoModified description
85960view19:58, 21 June 2016AAR&CoModified description
85959view19:55, 21 June 2016AAR&CoEditing Interactions
85958view19:53, 21 June 2016AAR&CoEditing Cell Positioning
85957view19:51, 21 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ANG2GeneProductENSG00000091879 (Ensembl)
AT1/2RGeneProductIdentifier Not Found
CTGFGeneProductENSG00000118523 (Ensembl)
Calcium Calneurin PathwayPathwayN/A (WikiPathways) Identifer Not Found
ERK1GeneProduct5595 (NCBI Protein)
ERK2GeneProduct5594 (NCBI Protein)
EndoglinProteinF5GX88 (Uniprot-TrEMBL)
FibrillinsProteinF6U495 (Uniprot-TrEMBL) Firbrillins Not Specified
JNK1GeneProduct5599 (NCBI Protein)
LTBPsGeneProductENSG00000049323 (Ensembl) LTBP Not Specified
PAI-1ProteinQ5VU21 (Uniprot-TrEMBL)
PeriostinProteinB1ALD9 (Uniprot-TrEMBL)
RUNX2GeneProductENSG00000124813 (Ensembl)
SHCAGeneProduct6464 (NCBI Protein)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TGFBR3GeneProductENSG00000069702 (Ensembl)
Tak1GeneProduct7182 (NCBI Protein)
p38GeneProduct1432 (NCBI Protein)

Annotated Interactions

No annotated interactions

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