FTO obesity variant mechanism (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Rosen CJ, Ingelfinger JR; ''Unraveling the Function of FTO Variants.''; N Engl J Med, 2015 PubMed Europe PMC Scholia
2. Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M; ''FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.''; N Engl J Med, 2015 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	141666	view	04:56, 21 November 2025	Eweitz	Clear cached dimensions
	141665	view	04:56, 21 November 2025	Eweitz	Economize layout
	134174	view	00:54, 16 July 2024	Eweitz	Ontology Term : 'beige adipocyte' added !
	134173	view	00:53, 16 July 2024	Eweitz	Ontology Term : 'adipocyte' added !
	134172	view	00:53, 16 July 2024	Eweitz	Ontology Term : 'white adipocyte' added !
	128422	view	17:15, 4 February 2024	Eweitz	Standardize case
	124812	view	21:47, 11 December 2022	AlexanderPico	fixed citations
	124774	view	06:17, 11 December 2022	AlexanderPico	RelX limits
	123389	view	06:20, 23 July 2022	Egonw	Made a pathway clickable
	117112	view	21:40, 17 May 2021	Eweitz	Modified title
	97679	view	13:16, 1 June 2018	AMTan	Ontology Term : 'obesity' added !
	89858	view	12:25, 6 October 2016	Mkutmon	Modified description
	87514	view	01:52, 25 July 2016	AlexanderPico	Ontology Term : 'disease pathway' added !
	87513	view	01:52, 25 July 2016	AlexanderPico	Ontology Term : 'obesity disease pathway' added !
	81707	view	04:52, 24 August 2015	Egonw	Encoded the SNP information as states, so that both the gene and the SNP has xrefs.
	81678	view	23:33, 22 August 2015	AlexanderPico	Adding newlines characters to description
	81677	view	23:32, 22 August 2015	AlexanderPico	Modified description
	81676	view	23:28, 22 August 2015	AlexanderPico	Added second ref
	81675	view	23:23, 22 August 2015	AlexanderPico	Modified description
	81674	view	23:10, 22 August 2015	AlexanderPico	Adjusted centering
	81673	view	23:10, 22 August 2015	AlexanderPico	Completed datanodes, layout and lit ref
	81672	view	22:58, 22 August 2015	AlexanderPico	Periodical save, work in progress
	81664	view	17:53, 22 August 2015	AlexanderPico	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ARID5B	GeneProduct	ENSG00000150347 (Ensembl)
FTO rs1421085 C risk allele	GeneProduct
FTO rs1421085 T allele	GeneProduct
Fatty Acid Oxidation	Pathway	WP368 (WikiPathways)
IRX3	GeneProduct	ENSG00000177508 (Ensembl)
IRX5	GeneProduct	ENSG00000176842 (Ensembl)
PPARGC1A	GeneProduct	ENSG00000109819 (Ensembl)
PRDM16	GeneProduct	ENSG00000142611 (Ensembl)
TBX1	GeneProduct	ENSG00000184058 (Ensembl)
UCP1	GeneProduct	ENSG00000109424 (Ensembl)

Annotated Interactions

No annotated interactions