Eicosanoid synthesis (Homo sapiens)

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12-HETELipox = LipoxygenaseArachadonic Acid5-HETEPGE2HP = Hydroperoxy12-HPETEdiH = DihydroxyPG = Prostaglandin5-HPETEH = HydroxyLTD4PGF2-alphaPGI2LTE4LTB4Cell MembraneTXB2LT = LeukotrieneTXA2PGH2LTC415-HETETXA3TX = Thromboxane15-HPETE6-KetoPGF2-alphaPGD2LTA4ETE = Eicosatetraenoic AcidPTGDSALOX5APTBXAS1GGT1PTGESALOX15BPLA2G2AALOX15PTGES2ALOX5Peroxidase?Peroxidase?ALOX5PGD2 11-ketoreducLTA4HIPLA2(GAMMA)ALOX5APDPEP1ALOX12PTGS2PTGS1PGE2 9-ketoreducPLA2G6PTGISPLA2G6Peroxidase?ALOX15LTC4S


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Schieber A, Frank RW, Ghisla S; ''Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase.''; Eur J Biochem, 1992 PubMed Europe PMC Scholia
  2. Korff JM, Jarabak J; ''Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney.''; Methods Enzymol, 1982 PubMed Europe PMC Scholia
  3. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia
  4. Suzuki-Yamamoto T, Nishizawa M, Fukui M, Okuda-Ashitaka E, Nakajima T, Ito S, Watanabe K; ''cDNA cloning, expression and characterization of human prostaglandin F synthase.''; FEBS Lett, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141615view02:52, 20 November 2025EweitzClear deprecated metadata rendering
137593view07:35, 5 March 2025EgonwCleaned the BioPax
137592view07:34, 5 March 2025EgonwModified description
136925view19:34, 26 February 2025KhanspersModified description
124883view08:31, 22 December 2022EgonwModified description
124767view10:04, 10 December 2022EgonwFixed two datasources
124766view11:05, 9 December 2022Conroy lipids
124765view10:32, 9 December 2022Conroy lipidsmore conversion to uniprot, and remove duplication of AA formation from membrane lipids
124764view10:00, 9 December 2022Conroy lipidsstatdardise protein/geneproduct to uniprot (round 1)
124763view09:32, 9 December 2022Conroy lipidsadd rhea change arrows and sort out identity of HETE/HpETE lipids
124761view14:11, 8 December 2022Conroy lipidsadd more rheas to arachidonateremove spurious PNPLA3
124760view13:50, 8 December 2022Conroy lipidsadded rheas to prostaglandin H2 reactions, and converted arrows to mim-conversion
124733view15:29, 7 December 2022Conroy lipidsconvert arrows to mim-conversion and add rhea IDs to the leukotriene arm
120547view17:50, 14 December 2021Conroy lipidsupdate most lipids to lipidmaps identifiers
117707view12:26, 22 May 2021EweitzModified title
106700view13:09, 17 September 2019MaintBotHMDB identifier normalization
106398view21:30, 28 August 2019KhanspersModified description
105578view06:32, 9 August 2019KhanspersModified description
102907view10:58, 28 January 2019DeSlModified description
102906view10:56, 28 January 2019DeSlChanged layout slightly, and annotated 2 missing metabolites.
98574view15:40, 17 September 2018DeSlModified description
98571view15:39, 17 September 2018DeSlChanged layout, coloured outside of node orange.
98564view13:36, 17 September 2018DeSlModified description
98563view13:32, 17 September 2018DeSlChanged layout, removed node colour.
98452view12:49, 7 September 2018DeSlRemoved "last modified" item
98451view12:49, 7 September 2018DeSlModified description
98450view12:48, 7 September 2018DeSlSLight layout change
98449view12:47, 7 September 2018DeSlOne more ID.
98448view12:45, 7 September 2018DeSlAnnotated more nodes.
98447view12:41, 7 September 2018DeSlAdded more IDs to new LipidMaps content
98431view15:39, 6 September 2018DeSlAdded remaining lipids from lipidmaps
98430view15:24, 6 September 2018DeSlModified description
98429view15:23, 6 September 2018DeSlReverted to version '15:22, 6 September 2018' by DeSl
98428view15:23, 6 September 2018DeSlModified description
98427view15:22, 6 September 2018DeSlModified description
98426view15:22, 6 September 2018DeSlModified description
98425view15:21, 6 September 2018DeSlModified description
98424view15:19, 6 September 2018DeSlModified description
98423view15:18, 6 September 2018DeSlModified description
98422view15:13, 6 September 2018DeSlModified description
98421view15:10, 6 September 2018DeSlAdded info from LipidMaps PW.
89514view10:45, 16 September 2016Mkutmonontology tag fix
89469view13:39, 15 September 2016Mkutmonremove space from ontology term id
82702view07:46, 23 October 2015EgonwReplaced to CAS numbers with the ChEBI identifiers: 70608-72-9 cannot be 5-HETE, 12-HETE, and 15-HETE at the same time.
79809view16:44, 16 April 2015Mkutmonfixed unconnected line
71381view18:40, 17 October 2013MaintBotAutomated update of data sources
67184view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
63178view20:30, 8 May 2013MaintBotUpdating gpml version
45234view17:44, 7 October 2011AlexanderPicoOntology Term : 'epithelial cell' added !
45226view17:36, 7 October 2011AlexanderPicoOntology Term : 'inflammatory response pathway' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALOX12GeneProduct239 (Entrez Gene)
ALOX15GeneProduct246 (Entrez Gene)
ALOX15BGeneProduct247 (Entrez Gene)
ALOX5GeneProduct240 (Entrez Gene)
ALOX5APGeneProduct241 (Entrez Gene)
DPEP1GeneProduct1800 (Entrez Gene)
GGT1GeneProduct2678 (Entrez Gene)
IPLA2(GAMMA)GeneProduct50640 (Entrez Gene)
LTA4HGeneProduct4048 (Entrez Gene)
LTC4SGeneProduct4056 (Entrez Gene)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct5320 (Entrez Gene)
PLA2G6GeneProduct8398 (Entrez Gene)
PTGDSGeneProduct5730 (Entrez Gene)
PTGES2GeneProduct80142 (Entrez Gene)
PTGESGeneProduct9536 (Entrez Gene)
PTGISGeneProduct5740 (Entrez Gene)
PTGS1GeneProduct5742 (Entrez Gene)
PTGS2GeneProduct5743 (Entrez Gene)
Peroxidase?GeneProduct
TBXAS1GeneProduct6916 (Entrez Gene)

Annotated Interactions

No annotated interactions

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