Sulindac metabolic pathway (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H; ''Studies on the metabolism and biological activity of the epimers of sulindac.''; Drug Metab Dispos, 2011 PubMed Europe PMC Scholia
2. Etienne F, Resnick L, Sagher D, Brot N, Weissbach H; ''Reduction of Sulindac to its active metabolite, sulindac sulfide: assay and role of the methionine sulfoxide reductase system.''; Biochem Biophys Res Commun, 2003 PubMed Europe PMC Scholia
3. Hamman MA, Haehner-Daniels BD, Wrighton SA, Rettie AE, Hall SD; ''Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases. Comparison of human liver and kidney microsomes and mammalian enzymes.''; Biochem Pharmacol, 2000 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	139963	view	10:50, 13 July 2025	Egonw	The human FMO here is actually FMO3
	117834	view	15:10, 22 May 2021	Eweitz	Modified title
	105115	view	13:43, 8 July 2019	DeSl	Changed ID for FMO from wikidata to interpro.
	102205	view	14:56, 9 December 2018	Egonw	Modified description
	102204	view	14:55, 9 December 2018	Egonw	Modified title
	102203	view	14:54, 9 December 2018	Egonw	Modified title
	102202	view	14:54, 9 December 2018	Egonw	Replaced a Wikipedia with a Wikidata identifier.
	97769	view	13:33, 7 June 2018	Maxvanson	Modified description
	92293	view	12:43, 19 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
	88583	view	19:21, 11 August 2016	Mkutmon	fix unconnected lines
	87597	view	08:13, 25 July 2016	MirellaKalafati	Ontology Term : 'classic metabolic pathway' added !
	70621	view	15:07, 16 August 2013	Egonw	How did I manage to switch the R and S epimer??
	70618	view	14:53, 16 August 2013	Egonw	Humanized the pathway: human Ensemble IDs.
	70617	view	14:39, 16 August 2013	Egonw	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
CYP1A2	GeneProduct	ENSG00000140505 (Ensembl)
CYP1B1	GeneProduct	ENSG00000138061 (Ensembl)
FMO	GeneProduct	Flavin-containing monooxygenase (Wikipedia)
MsrA	GeneProduct	ENSG00000175806 (Ensembl)
MsrB2	GeneProduct	ENSG00000148450 (Ensembl)
MsrB3	GeneProduct	ENSG00000174099 (Ensembl)
Sulfindac sulfide	Metabolite	4509492 (Chemspider)
Sulindac sulfone	Metabolite	4582441 (Chemspider)	The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
Sulindac-R	Metabolite	16046677 (PubChem-compound)
Sulindac-S	Metabolite	11245227 (PubChem-compound)

Annotated Interactions

No annotated interactions