Ketone bodies synthesis and degradation (Bos taurus)

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1GlycolysisSterol biosynthesis(HMG-CoA cycle)* pathway-regulated enzymes: HMG-CoA synthase, mtFatty acid metabolismPyruvate metabolismFatty acid beta-oxidationHMGCLBDH1OXCT1Acetyl-CoAAcetoacetyl-CoAHMGCS23-Hydroxy-3-methylglutaryl-CoA3-Hydroxy-butyrateAcetoacetateAcetyl-CoAACAT1


Description

Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: Wikipedia

Comments

GenMAPP notes 
Ketogenesis (Human)
GenMAPP remarks 
Adapted from KEGG
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP311(r21335) with a 55% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Fukao T, Lopaschuk GD, Mitchell GA; ''''; , PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137047view21:26, 26 February 2025KhanspersModified description
117614view11:40, 21 May 2021EweitzModified title
115808view16:22, 13 March 2021EgonwPoint to the pathways of the right species
115807view16:20, 13 March 2021EgonwMade two pathways clickable
80878view15:29, 30 June 2015Mkutmonhomology conversion
79149view06:17, 5 March 2015MaintBotUpdated conversion from Hs
67672view11:47, 26 June 2013DdiglesOntology Term : 'ketone bodies metabolic pathway' added !
63322view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
48298view04:03, 18 May 2012KhanspersUpdating PubChem xrefs
48296view03:59, 18 May 2012MaintBotAutomatic update of PubChem xrefs
40503view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35387view09:28, 12 February 2010Thomasadded literature, fixed metabolite xrefs
35379view09:18, 12 February 2010ThomasModified description
35378view09:17, 12 February 2010ThomasModified description
33746view23:57, 8 December 2009MaintBotAutomatic update of empty xrefs
30584view22:10, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3-Hydroxy-3-methylglutaryl-CoAMetabolite1553-55-5 (CAS)
3-Hydroxy-butyrateMetabolite441 (PubChem-compound)
ACAT1GeneProduct511082 (Entrez Gene)
AcetoacetateMetabolite6971017 (PubChem-compound)
Acetoacetyl-CoAMetabolite1420-36-6 (CAS)
Acetyl-CoAMetabolite72-89-9 (CAS)
BDH1GeneProduct534090 (Entrez Gene)
HMGCLGeneProduct317658 (Entrez Gene)
HMGCS2GeneProduct503684 (Entrez Gene)
OXCT1GeneProduct535804 (Entrez Gene)

Annotated Interactions

No annotated interactions
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