NSAIDs mechanism of action (Homo sapiens)

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Description

Nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting the cyclooxygenase enzymes PTGS1 (COX-1) and PTGS2 (COX-2), with different NSAIDs showing varying selectivity for the COX-2 isoform. This inhibition blocks the conversion of arachidonic acid into prostaglandins (PGs). Inspired by Figure 1 in PMID:32322101.

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Ontology Terms

 

Bibliography

  1. Schjerning AM, McGettigan P, Gislason G; ''Cardiovascular effects and safety of (non-aspirin) NSAIDs.''; Nat Rev Cardiol, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140914view11:17, 30 October 2025EweitzClear deprecated metadata rendering
139179view13:02, 24 May 2025EweitzModified description
139178view12:58, 24 May 2025EweitzRefine gene identifiers
136464view13:09, 3 February 2025EweitzModified description
136463view13:08, 3 February 2025EweitzOntology Term : 'drug pathway' added !
136462view13:07, 3 February 2025EweitzWiden nodes
136461view13:07, 3 February 2025EweitzWiden node
136460view13:06, 3 February 2025EweitzWiden node
136459view13:06, 3 February 2025EweitzRemove anchor
136458view13:05, 3 February 2025EweitzConnect downstream effects
136457view13:01, 3 February 2025EweitzAdd literature reference
136456view13:00, 3 February 2025EweitzAdd more nodes, interactions, labels
136454view03:08, 3 February 2025EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AngiogenesisPathwayWP1539 (WikiPathways)
Arachidonic acidMetabolite
CelecoxibMetaboliteDB00482 (DrugBank)
Cell proliferationQ189101 (Wikidata)
DiclofenacMetaboliteDB00586 (DrugBank)
HemostasisQ487937 (Wikidata)
IbuprofenMetaboliteDB01050 (DrugBank)
InflammationQ101991 (Wikidata)
MetastasisQ181876 (Wikidata)
NaproxenMetaboliteDB00788 (DrugBank)
PGA1MetaboliteCHEBI:15545 (ChEBI)
PGD2MetaboliteCHEBI:15555 (ChEBI)
PGE1MetaboliteCHEBI:15544 (ChEBI)
PGE2MetaboliteCHEBI:15551 (ChEBI)
PGF2aMetaboliteCHEBI:15553 (ChEBI)
PGG2MetaboliteCHEBI:27647 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
PGI2MetaboliteCHEBI:15552 (ChEBI)
PTGS1GeneProductENSG00000095303 (Ensembl) "COX1" in source
PTGS2GeneProductENSG00000073756 (Ensembl) "COX2" in source
PainQ81938 (Wikidata)
Protection of gastric mucosaQ383249 (Wikidata)
RofecoxibMetaboliteDB00533 (DrugBank)
Tissue injuryQ21119857 (Wikidata)

Annotated Interactions

No annotated interactions

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