Effect of dasatinib on the BCR-ABL signaling pathway (Homo sapiens)
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Description
Phosphorylation sites that are found to be suppressed by Dasatinib are shown. Based on fig 6 from https://pmc.ncbi.nlm.nih.gov/articles/PMC2816010/Phosphorylation site information is based on the left-side panel in the figure; not all sites could be verified in independent sources (e.g. PhosphositePlus).
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Ontology Terms
Saving...Bibliography
- Pan C, Olsen JV, Daub H, Mann M; ''Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.''; Mol Cell Proteomics, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| PIK3CA | GeneProduct | 5290 (Entrez Gene)  | |
| PIK3R1 | GeneProduct | 5295 (Entrez Gene) | |
| ABL1 | GeneProduct | 25 (Entrez Gene) | |
| AKT1 | GeneProduct | 207 (Entrez Gene) | OCR lexicon match: AKT |
| AKT2 | GeneProduct | 208 (Entrez Gene) | OCR lexicon match: AKT |
| AKT3 | GeneProduct | 10000 (Entrez Gene) | OCR lexicon match: AKT |
| ARAF | GeneProduct | 369 (Entrez Gene) | OCR lexicon match: RAF |
| ATF2 | GeneProduct | 1386 (Entrez Gene) | OCR lexicon match: ATF2 |
| BCAR1 | GeneProduct | 9564 (Entrez Gene) | OCR lexicon match: CAS |
| BCL2 | GeneProduct | 596 (Entrez Gene) | OCR lexicon match: BCL2 |
| BCL9 | GeneProduct | 607 (Entrez Gene) | |
| BCLAF1 | GeneProduct | 9774 (Entrez Gene) | OCR lexicon match: BCLAF1 |
| BCR | GeneProduct | 613 (Entrez Gene) | |
| BRAF | GeneProduct | 673 (Entrez Gene) | OCR lexicon match: RAF |
| CBL | GeneProduct | 867 (Entrez Gene) | OCR lexicon match: CBL |
| CRK | GeneProduct | 1398 (Entrez Gene) | OCR lexicon match: CRK |
| CRKL | GeneProduct | 1399 (Entrez Gene) | |
| DOK1 | GeneProduct | 1796 (Entrez Gene) | |
| EIF4B | GeneProduct | 1975 (Entrez Gene) | OCR lexicon match: EIF4B |
| GAB2 | GeneProduct | 9846 (Entrez Gene) | OCR lexicon match: GAB2 |
| GRB2 | GeneProduct | 2885 (Entrez Gene) | |
| HRAS | GeneProduct | 3265 (Entrez Gene) | OCR lexicon match: RAS |
| HSPB1 | GeneProduct | 3315 (Entrez Gene) | OCR lexicon match: HSP27 |
| HSPB2 | GeneProduct | 3316 (Entrez Gene) | OCR lexicon match: HSP27 |
| INPP5D | GeneProduct | 3635 (Entrez Gene) | |
| JAK-STAT signaling | Pathway | ||
| KRAS | GeneProduct | 3845 (Entrez Gene) | OCR lexicon match: RAS |
| MAP3K2 | GeneProduct | 10746 (Entrez Gene) | OCR lexicon match: MEKK2 |
| MAPK11 | GeneProduct | 5600 (Entrez Gene) | |
| MAPK14 | GeneProduct | 1432 (Entrez Gene) | |
| MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
| MAPK3 | GeneProduct | 5595 (Entrez Gene) | |
| MEF2C | GeneProduct | 4208 (Entrez Gene) | OCR lexicon match: MEF2C |
| NRAS | GeneProduct | 4893 (Entrez Gene) | OCR lexicon match: RAS |
| PTK2 | GeneProduct | 5747 (Entrez Gene) | OCR lexicon match: FAK |
| PXN | GeneProduct | 5829 (Entrez Gene) | |
| RAF1 | GeneProduct | 5894 (Entrez Gene) | OCR lexicon match: RAF |
| RPS6KA1 | GeneProduct | 6195 (Entrez Gene) | OCR lexicon match: RSK |
| SHC1 | GeneProduct | 6464 (Entrez Gene) | OCR lexicon match: SHC |
| SHC2 | GeneProduct | 25759 (Entrez Gene) | OCR lexicon match: SHC |
| SHC3 | GeneProduct | 53358 (Entrez Gene) | OCR lexicon match: SHC |
| SHC4 | GeneProduct | 399694 (Entrez Gene) | OCR lexicon match: SHC |
| SOS1 | GeneProduct | 6654 (Entrez Gene) | |
| SPAG1 | GeneProduct | 6674 (Entrez Gene) | |
| SRC | GeneProduct | 6714 (Entrez Gene) | OCR lexicon match: SRC |
| VAV1 | GeneProduct | 7409 (Entrez Gene) |
Annotated Interactions
No annotated interactions
