Cigarette smoke induced lung fibrosis (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Makena P, Kikalova T, Prasad GL, Baxter SA; ''Oxidative Stress and Lung Fibrosis: Towards an Adverse Outcome Pathway.''; Int J Mol Sci, 2023 PubMed Europe PMC Scholia
2. Estornut C, Milara J, Bayarri MA, Belhadj N, Cortijo J; ''Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis.''; Front Pharmacol, 2021 PubMed Europe PMC Scholia
3. Ding R, Ren X, Sun Q, Sun Z, Duan J; ''An integral perspective of canonical cigarette and e-cigarette-related cardiovascular toxicity based on the adverse outcome pathway framework.''; J Adv Res, 2023 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	135749	view	13:52, 8 November 2024	Eweitz	Modified title
	135744	view	13:00, 6 November 2024	Marvin M2	added literature references and visual cleanup
	135743	view	12:33, 6 November 2024	Marvin M2	added KE IDs
	135742	view	12:26, 6 November 2024	Marvin M2	Ontology Term : 'pulmonary fibrosis' added !
	129277	view	13:10, 17 March 2024	Burritaco	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
Cigarette smoke exposure
Collagen accumulation	Event	68 (AOP-Wiki KE)
Collagen biosynthesis and modifying enzymes	Pathway	WP2725 (WikiPathways)
Fibrosis	Event	1276 (AOP-Wiki KE)
Growth factor release
Increase of ROS
Increased activation of nuclear factor kappa B (NF-kB)	Event	1172 (AOP-Wiki KE)
Lung epithelial cells
NF-kB pathway	Pathway	WP4562 (WikiPathways)
Overview of inflammatory mediators	Pathway	WP5095 (WikiPathways)
Oxidative stress and ROS	Pathway	WP554 (WikiPathways)
Regeneration and normal lung function
Release of pro-inflammatory mediators		1469 (Other)

Annotated Interactions

No annotated interactions