Synthesis of ceramides and 1-deoxyceramides (Homo sapiens)

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Lc3CerSGMS1HexadecenalSPTLC1alanineUGT8SPHK1A3GALT2ganglioside GM4DESCerP(d18:1/16:0)CERS4GalactosylceramideKDSRceramideSphingosine1-O-acyl-ceramideA4GALTgloboside Gb3CerSGMS2DihydroceramideCERS2lactosylceramideGA2CERKSphinganineSphingolipid metabolism overviewGlucosylceramidesphingomyelinsPalmitoyl-CoA3-ketosphinganineDGAT1ASAH1PhosphoethanolamineS1PB3GNT5serineS1P lyaseCERS3isogloboside iGb3CerB4GALNT1sphingosine-1-phosphateUGCGCERS1sulphatide32323222331-Deoxyceramide31-Deoxy-3-ketosphinganine1-deoxysphinganine31-Deoxysphingosine1-Deoxydihydroceramide33B4GALT11CERS5CERS6CERS4CERS1CERS2CERS3CERS5CERS6ASAH13Sphingolipid pathwaySerine metabolism


Description

Synthesis of ceramides and 1-deoxyceramides from serine and alanine, respectively, including the synthesis of complex glycosphingolipids in humans. Multiple more complex sphingolipid synthesis reactions were added to improve pathway versatility. 1-deoxyceramide synthesis shows a lot of similarities with ceramide synthesis but does not come close in terms of documentation, hence this comprehensive figure.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Shayman JA; ''''; , PubMed Europe PMC Scholia
  2. Chatterjee S, Balram A, Li W; ''Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
  3. Sen P, Hyötyläinen T, Orešič M; ''1-Deoxyceramides - Key players in lipotoxicity and progression to type 2 diabetes?''; Acta Physiol (Oxf), 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134708view12:14, 26 July 2024EweitzModified description
134707view12:13, 26 July 2024EweitzModified description
134706view12:12, 26 July 2024EweitzUse singular
134705view12:11, 26 July 2024EweitzStandardize case
134704view12:09, 26 July 2024EweitzOmit species in pathway name in diagram, per convention
122165view14:04, 14 March 2022QuintenLokAdded pathway nodes
122158view12:07, 14 March 2022QuintenLokOntology Term : 'lacto-series glycosphingolipid metabolic pathway' added !
122157view12:06, 14 March 2022QuintenLokOntology Term : 'animal cell' added !
122156view12:02, 14 March 2022QuintenLokOntology Term : 'sphingolipid biosynthetic pathway' added !
122155view12:02, 14 March 2022QuintenLokOntology Term : 'ceramide signaling pathway' added !
122154view11:55, 14 March 2022QuintenLokAttempt to get the shayman reference to properly show up on wikipathways
122152view11:52, 14 March 2022QuintenLokFixed HMDB identifiers to match contemporary tags
122151view11:45, 14 March 2022QuintenLokMade the DGAT1 comment more descriptive
122145view11:41, 14 March 2022QuintenLokModified description
122144view11:38, 14 March 2022QuintenLokModified title
122143view11:38, 14 March 2022QuintenLokModified title
122126view14:21, 11 March 2022QuintenLokfixed layout and references
122108view00:27, 11 March 2022DeSlmade all Metabolite nodes blue
122067view14:25, 9 March 2022QuintenLokModified description
122066view14:23, 9 March 2022QuintenLokFixed remaining broken interaction terms
122065view14:16, 9 March 2022QuintenLokfixed 1 unatached interaction
121587view16:49, 21 February 2022QuintenLokAdded database identifiers for everything except deoxylipids, cant seem to find those
121442view13:46, 17 February 2022QuintenLoka lot more enzymes, more specificity
121433view12:53, 17 February 2022QuintenLokAdded a lot more specific enzymes and improved specificity of the glucosylceramide pathway
121361view12:36, 16 February 2022QuintenLokAdded a metabolite and an enzyme (+reference)
121359view11:44, 16 February 2022QuintenLokReverted to version '11:42, 16 February 2022' by QuintenLok
121358view11:43, 16 February 2022QuintenLok
121357view11:42, 16 February 2022QuintenLokNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-Deoxy-3-ketosphinganineMetaboliteCHEBI:17862 (ChEBI)
1-DeoxyceramideMetaboliteCHEBI:52639 (ChEBI)
1-DeoxydihydroceramideMetaboliteHMDB0006752 (HMDB)
1-DeoxysphingosineMetaboliteHMDB0000252 (HMDB)
1-O-acyl-ceramideMetaboliteCHEBI:133444 (ChEBI)
1-deoxysphinganineMetaboliteCHEBI:67109 (ChEBI)
3-ketosphinganineMetaboliteCHEBI:17862 (ChEBI)
A3GALT2GeneProductENSG00000184389 (Ensembl)
A4GALTGeneProductENSG00000128274 (Ensembl)
ASAH1GeneProductENSG00000104763 (Ensembl)
B3GNT5GeneProductENSG00000176597 (Ensembl)
B4GALNT1GeneProductENSG00000135454 (Ensembl)
B4GALT1GeneProductENSG00000086062 (Ensembl)
CERKGeneProductENSG00000100422 (Ensembl)
CERS1GeneProductENSG00000223802 (Ensembl)
CERS2GeneProductENSG00000143418 (Ensembl)
CERS3GeneProductENSG00000154227 (Ensembl)
CERS4GeneProductENSG00000090661 (Ensembl)
CERS5GeneProductENSG00000139624 (Ensembl)
CERS6GeneProductENSG00000172292 (Ensembl)
CerP(d18:1/16:0)MetaboliteCHEBI:72963 (ChEBI)
DESGeneProductENSG00000175084 (Ensembl)
DGAT1GeneProductENSG00000185000 (Ensembl) Uncertain, source material did not specify what protein isoform is responsible for this reaction.
DihydroceramideMetaboliteHMDB0006752 (HMDB)
GA2MetaboliteCHEBI:36774 (ChEBI)
GalactosylceramideMetaboliteCHEBI:18390 (ChEBI)
GlucosylceramideMetaboliteCHEBI:18368 (ChEBI)
HexadecenalMetaboliteHMDB0060482 (HMDB)
KDSRGeneProductENSG00000119537 (Ensembl)
Lc3CerMetaboliteHMDB0062485 (HMDB)
Palmitoyl-CoAMetaboliteCHEBI:15525 (ChEBI)
PhosphoethanolamineMetaboliteCHEBI:17553 (ChEBI)
S1P lyaseGeneProduct
S1PMetaboliteCHEBI:37550 (ChEBI)
SGMS1GeneProductENSG00000198964 (Ensembl)
SGMS2GeneProductENSG00000164023 (Ensembl)
SPHK1GeneProductENSG00000176170 (Ensembl)
SPTLC1ProteinO15269 (Uniprot-TrEMBL)
Serine metabolismPathwayWP4688 (WikiPathways)
SphinganineMetaboliteHMDB0000269 (HMDB)
Sphingolipid metabolism overviewPathwayWP4725 (WikiPathways)
Sphingolipid pathwayPathwayWP1422 (WikiPathways)
SphingosineMetaboliteHMDB0000252 (HMDB)
UGCGGeneProductENSG00000148154 (Ensembl)
UGT8GeneProductENSG00000174607 (Ensembl)
alanineMetaboliteCHEBI:16449 (ChEBI)
ceramideMetaboliteCHEBI:52639 (ChEBI)
ganglioside GM4MetaboliteCHEBI:27499 (ChEBI)
globoside Gb3CerMetaboliteCHEBI:88154 (ChEBI)
isogloboside iGb3CerMetaboliteCHEBI:140817 (ChEBI)
lactosylceramideMetaboliteCHEBI:134507 (ChEBI)
serineMetaboliteCHEBI:17822 (ChEBI)
sphingomyelinsMetaboliteCHEBI:62490 (ChEBI)
sphingosine-1-phosphateMetaboliteCHEBI:37550 (ChEBI)
sulphatideMetaboliteCHEBI:18318 (ChEBI)

Annotated Interactions

No annotated interactions

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