Protein alkylation leading to liver fibrosis (Homo sapiens)

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Revision as of 12:50, 28 February 2023 by Marvin M2 (Talk | contribs)
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1ApoptosisKE68: Collagen accumulationallyl alcoholApoptosis Modulation and SignalingKE265: Stellate cell activationTNF alpha Signaline PathwayDimethylnitrosamineKE276: TGFbeta1 expression up regulationCCl4retinolCollagen biosynthesis and modifying enzymesKE344: Liver FibrosisthioacetamideKE244: Protein alkylationKE134: Increased activation and recruitment of Kupffer CellsKE55: Cell injury/deathTGF-beta signaling pathway


Description

Protein alkylation leading to liver fibrosis This pathway is based on descriptive text of the adverse outcome pathway (AOP) on https://aopwiki.org/aops/38

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Quality Tags

Ontology Terms

 

Bibliography

  1. Horvat T, Landesmann B, Lostia A, Vinken M, Munn S, Whelan M; ''Adverse outcome pathway development from protein alkylation to liver fibrosis.''; Arch Toxicol, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125572view13:09, 28 February 2023Marvin M2created event nodes
125571view13:07, 28 February 2023Marvin M2added KE nodes
125570view12:50, 28 February 2023Marvin M2Added tgf-beta pathway
114317view16:15, 6 January 2021Marvin M2Updated layout
114316view16:06, 6 January 2021Marvin M2Renewed and removed molecular entities to follow AOP guidelines
96718view16:23, 30 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96693view15:51, 27 March 2018Marvin M2Added references to Key Events and Key Event Relationships
93134view13:39, 31 July 2017Marvin M2Added the main reference for this AOP
92321view11:11, 22 May 2017Marvin M2Ontology Term : 'liver disease pathway' added !
92320view11:04, 22 May 2017Marvin M2Ontology Term : 'liver disease' added !
92296view12:59, 19 May 2017Marvin M2Modified description
92294view12:47, 19 May 2017Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apoptosis Modulation and SignalingPathwayWP1772 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
CCl4MetaboliteCHEBI:27385 (ChEBI)
Collagen biosynthesis and modifying enzymesPathwayWP2725 (WikiPathways)
DimethylnitrosamineMetaboliteCHEBI:35807 (ChEBI)
KE134: Increased activation and recruitment of Kupffer Cells134 (Unknown data source)
KE244: Protein alkylation244 (Unknown data source)
KE265: Stellate cell activation265 (Unknown data source)
KE276: TGFbeta1 expression up regulation276 (Unknown data source)
KE344: Liver Fibrosis344 (Unknown data source)
KE55: Cell injury/death55 (Unknown data source)
KE68: Collagen accumulation68 (Unknown data source)
TGF-beta signaling pathwayPathwayWP366 (WikiPathways)
TNF alpha Signaline PathwayPathwayWP231 (WikiPathways)
allyl alcoholMetaboliteCHEBI:16605 (ChEBI)
retinolMetaboliteCHEBI:50211 (ChEBI)
thioacetamideMetaboliteQ416253 (Wikidata)

Annotated Interactions

No annotated interactions

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