SARS-CoV-2 altering angiogenesis via NRP1 (Homo sapiens)
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Description
Mechanism of how the SARS-cov-2 virus is involved in altering angiogenesis and how NRP1 might play a role as an entry factor for the virus.
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Ontology Terms
Saving...Bibliography
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- Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, Shoemark DK, Simón-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi Y; ''Neuropilin-1 is a host factor for SARS-CoV-2 infection.''; Science, 2020 PubMed Europe PMC Scholia
- Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M; ''Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.''; Cell, 1998 PubMed Europe PMC Scholia
- Mayi BS, Leibowitz JA, Woods AT, Ammon KA, Liu AE, Raja A; ''The role of Neuropilin-1 in COVID-19.''; PLoS Pathog, 2021 PubMed Europe PMC Scholia
- McFarland AJ, Yousuf MS, Shiers S, Price TJ; ''Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain.''; Pain Rep, 2021 PubMed Europe PMC Scholia
- Li ZL, Buck M; ''Neuropilin-1 Assists SARS-CoV-2 Infection by Stimulating the Separation of Spike Protein Domains S1 and S2.''; bioRxiv, 2021 PubMed Europe PMC Scholia
- Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, Stratton HJ, Cai S, Luo S, Gonzalez KB, Perez-Miller S, Patwardhan A, Ibrahim MM, Khanna R; ''SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia.''; bioRxiv, 2020 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ACE2 | GeneProduct | ENSG00000130234 (Ensembl)  | |
| Angiogenesis | Pathway | WP1993 (WikiPathways) | |
| FURIN | GeneProduct | ENSG00000140564 (Ensembl) | |
| KDR | GeneProduct | ENSG00000128052 (Ensembl) | |
| Membrane fusion | Pathway | Q6556360 (Wikidata) | |
| NRP1 | GeneProduct | ENSG00000099250 (Ensembl) | |
| S1 | Protein | Q106020256 (Wikidata) | |
| S2 | Protein | Q106020384 (Wikidata) | |
| Surface glycoprotein S | Protein | P0DTC2 (Uniprot-TrEMBL) | |
| VEGFA | GeneProduct | ENSG00000112715 (Ensembl) |
Annotated Interactions
No annotated interactions
