Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition (Homo sapiens)

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Description

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Ontology Terms

Bibliography

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History

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Compare	Revision	Action	Time	User	Comment
	140858	view	00:10, 30 October 2025	Eweitz	Clear deprecated metadata rendering
	137835	view	13:48, 8 March 2025	Eweitz	Refine padding
	137834	view	13:47, 8 March 2025	Eweitz	Economize layout
	137793	view	06:26, 8 March 2025	Egonw	Modified description
	116532	view	11:59, 7 May 2021	Eweitz	Modified title
	115242	view	17:13, 7 February 2021	Egonw	Replaced a link to a deleted pathway to another pathway about necrosis
	111416	view	10:33, 7 August 2020	Marvin M2	Modified description
	111407	view	16:10, 6 August 2020	Evelo	Modified description
	111406	view	16:09, 6 August 2020	Evelo	Modified description
	111405	view	16:05, 6 August 2020	Evelo	Modified description
	111404	view	16:04, 6 August 2020	Evelo	Modified description
	111403	view	15:51, 6 August 2020	Evelo	Ontology Term : 'Parkinson's disease' added !
	111402	view	15:43, 6 August 2020	Evelo	Modified description
	111401	view	15:43, 6 August 2020	Evelo	Ontology Term : 'Fanconi-like syndrome' added !
	111400	view	15:42, 6 August 2020	Evelo	Ontology Term : 'altered energy metabolic pathway' added !
	111399	view	15:39, 6 August 2020	Evelo	Modified title
	110993	view	17:50, 25 June 2020	Marvin M2	Modified title
	110831	view	12:58, 11 June 2020	Annabaya	Edit pathway node shapes
	110381	view	15:34, 8 May 2020	Annabaya	Ontology Term : 'immune response pathway' added !
	110378	view	15:29, 8 May 2020	Annabaya	Add pathway identifiers
	110314	view	22:12, 3 May 2020	Marvin M2	Connected unconnected lines
	110303	view	06:37, 3 May 2020	Egonw	Replaced a secondary ChEBI identifiers with a primary identifier.
	110271	view	13:53, 1 May 2020	Annabaya	Modified title
	110270	view	13:51, 1 May 2020	Annabaya	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
Apoptosis	Pathway	WP1772 (WikiPathways)
Decreased mitochondrial oxidative phosphorylation	Pathway	WP111 (WikiPathways)
Deguelin	Metabolite	CHEBI:4357 (ChEBI)
Ferroptosis	Pathway	WP4313 (WikiPathways)
Increased ROS	Pathway	WP3941 (WikiPathways)
Inhibition of mitochondrial Complex I	Pathway	WP4324 (WikiPathways)
Necrosis	Pathway	WP3383 (WikiPathways)
Parkinsonian motor deficits	Pathway	WP2371 (WikiPathways)
Rotenone	Metabolite	CHEBI:28201 (ChEBI)
[Autophagy]	Pathway
[Degeneration of DA neurons of nigrostratial pathway]	Pathway	WP2855 (WikiPathways)

Annotated Interactions

No annotated interactions