Pancreatic adenocarcinoma pathway (Homo sapiens)

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NucleusPancreatic ductal cellAnti-apoptotic genesNormal ductAngiogenesisDS DNA break repairGrowth inhibitionCell survivalARHGEF6PI3K-Akt SignalingApoptosisVEGF SignalingPathwayPAPIP3KRASTIAM1RAC1RAC2RAC3PAK4BUB1B-PAK6PAK1PAK2PAK3PAK6PAK5RHOACytoskeleton organizationCell motilityAKT1AKT2AKT3CHUKPIKBKBIKBKGPNFKB1RELABADPBCL2L1CASP9PRAF1MAP2K1PMAP2K2PPPMAPK1PPMAPK3PPProliferative genesRALGDSRALARALBPLD1RALBP1RAC1RAC2RAC3CDC42PIK3CAPIK3CBPIK3CDPIK3R1PIK3R2PIK3R3Supressed apoptosisARAFBRAFMAPK8MAPK9MAPK10TGFAEGFEGFRERBB2PIK3CAPIK3CBPIK3CDPIK3R1PIK3R2PIK3R3PIP3AKT1AKT2AKT3MTORPRPS6KB1RPS6KB2JAK1STAT1PSTAT3VEGFATGFB1TGFB2TGFB3TGFBR1TGFBR2SMAD2SMAD3SMAD4BRCA2RAD51TP53DNA damageCDKN1ABAXDDB2GADD45AGADD45BGADD45GBAK1POLKCDKN2ACDK4CDK6CCND1RB1E2F1E2F2E2F3G1/S Cell Cycle ControlAdenocarcinomaLegendActivating mutationInactivating mutationCell cycleTGFb SignalingPathway


Description

draft

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Quality Tags

Ontology Terms

 

Bibliography

  1. ''EGFR autophosphorylation''; Reactome,
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  3. Qi ZH, Xu HX, Zhang SR, Xu JZ, Li S, Gao HL, Jin W, Wang WQ, Wu CT, Ni QX, Yu XJ, Liu L; ''RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling.''; Int J Oncol, 2018 PubMed Europe PMC Scholia
  4. ''Pancreatic cancer - Homo sapiens (human)''; KEGG,
  5. Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A; ''Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer.''; Am J Pathol, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
142499view01:56, 11 March 2026Khanspersadded pathway identifier, converted interactions to graphical lines
142498view01:52, 11 March 2026Khanspersadded ptms
142489view16:46, 6 March 2026Khanspersupdated references
142485view02:16, 5 March 2026Khanspersadded ptms
142482view00:31, 4 March 2026Khanspersupdated disease progession graphic
142481view00:24, 4 March 2026Khanspersremoved TIAM1 arm without reference
142480view22:57, 3 March 2026Khansperseconomize layout
137087view22:03, 27 February 2025KhanspersModified description
134838view13:09, 27 July 2024EweitzMake cell type label more readable
134837view13:07, 27 July 2024EweitzRefine legend
134836view12:57, 27 July 2024EweitzFix truncated text, standardize case
127492view17:33, 11 October 2023Khanspersupdated phosphosites
127244view00:27, 26 August 2023Khanspersadded lit ref and updated description
123405view06:44, 23 July 2022EgonwMade five pathways clickable
105482view05:38, 8 August 2019KhanspersModified description
105445view04:56, 8 August 2019KhanspersModified description
105005view04:56, 28 June 2019KhanspersModified description
103768view00:26, 5 April 2019Khanspersupdated ERBB2 status and legend
97005view23:27, 25 April 2018KhanspersModified title
96948view06:21, 21 April 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
96946view20:43, 20 April 2018KhanspersModified title
96945view20:42, 20 April 2018KhanspersOntology Term : 'pancreatic ductal cell' added !
96944view20:41, 20 April 2018KhanspersModified description
96943view20:40, 20 April 2018Khanspersadded PKCG/RIPK4/PEBP1 module, and DUSP6
96942view20:03, 20 April 2018Khanspersupdated p16 label
96940view19:32, 20 April 2018Khansperslayout and update of progression graphic
96939view19:28, 20 April 2018Khanspersupdated layout
96938view19:27, 20 April 2018KhanspersModified description
96935view19:22, 20 April 2018KhanspersOntology Term : 'disease pathway' added !
96934view19:22, 20 April 2018KhanspersOntology Term : 'cancer pathway' added !
96933view19:22, 20 April 2018KhanspersOntology Term : 'Jak-Stat signaling pathway' added !
96932view19:22, 20 April 2018KhanspersModified title
96931view19:21, 20 April 2018KhanspersOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
96930view19:21, 20 April 2018KhanspersOntology Term : 'pancreatic adenocarcinoma' added !
96929view18:29, 20 April 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
ARHGEF6GeneProductENSG00000129675 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
BRCA2GeneProductENSG00000139618 (Ensembl)
BUB1B-PAK6GeneProductENSG00000259288 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK6GeneProductENSG00000105810 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN2AGeneProductENSG00000147889 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
Cell cyclePathwayWP179 (WikiPathways)
DDB2GeneProductENSG00000134574 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl)
E2F2GeneProductENSG00000007968 (Ensembl)
E2F3GeneProductENSG00000112242 (Ensembl)
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ERBB2GeneProductENSG00000141736 (Ensembl)
G1/S Cell Cycle ControlPathwayWP45 (WikiPathways)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PAMetaboliteCHEBI:18879 (ChEBI)
PAK1GeneProductENSG00000149269 (Ensembl)
PAK2GeneProductENSG00000180370 (Ensembl)
PAK3GeneProductENSG00000077264 (Ensembl)
PAK4GeneProductENSG00000130669 (Ensembl)
PAK5GeneProductENSG00000101349 (Ensembl)
PAK6GeneProductENSG00000137843 (Ensembl)
PI3K-Akt SignalingPathwayWP4172 (WikiPathways)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLD1GeneProductENSG00000075651 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RAC2GeneProductENSG00000128340 (Ensembl)
RAC3GeneProductENSG00000169750 (Ensembl)
RAD51GeneProductENSG00000051180 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RALAGeneProductENSG00000006451 (Ensembl)
RALBGeneProductENSG00000144118 (Ensembl)
RALBP1GeneProductENSG00000017797 (Ensembl)
RALGDSGeneProductENSG00000160271 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
RELAGeneProduct5970 (Entrez Gene)
RHOAGeneProductENSG00000067560 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPS6KB2GeneProductENSG00000175634 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TGFb Signaling PathwayPathway
TIAM1GeneProductENSG00000156299 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
VEGF Signaling PathwayPathway
VEGFAGeneProductENSG00000112715 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://oldclassic.wikipathways.org/index.php/Pathway:WP4263"
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