Lipid metabolism pathway (Homo sapiens)

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Lipid Droplet Mitochondria1LipogenesisATGLAKT3GlycerolipidmetabolismPRKAR1BGlycerophospholipidmetabolismPRKAR2BFatty acidelongationHSLACACAPRKAG3PDHA1PRKAG1ABHD5PRKACGBCAABCKDHAFASNACLYPRKACAPRKAA1ACSS2PRKACBPRKAB2AKT2PRKAB1PRKAA2AKT1PRKAG2ACSBG1BCFAPyruvateAcetylCoA(mit)CitrateAcetylCoA(cyt)MalonylCoAPalimitatePalimitateCoAAcetatePRKAR1APRKAR2ALipolysisTAGDAGMAGFreeFA


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Zhang X, Saarinen AM, Hitosugi T, Wang Z, Wang L, Ho TH, Liu J; ''Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia.''; Elife, 2017 PubMed Europe PMC Scholia
  2. Asfa AS, Qiu B, Wee S, Choi H, Gunaratne J, Tergaonkar V; ''Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.''; Sci Rep, 2016 PubMed Europe PMC Scholia
  3. Grahn TH, Zhang Y, Lee MJ, Sommer AG, Mostoslavsky G, Fried SK, Greenberg AS, Puri V; ''FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes.''; Biochem Biophys Res Commun, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137668view20:02, 6 March 2025KhanspersModified description
135480view05:10, 16 September 2024EgonwTake the neutral citric acid with more mappings
128420view17:11, 4 February 2024EweitzModified description
128419view17:04, 4 February 2024EweitzSlightly thin arrow
128418view17:02, 4 February 2024EweitzEconomize layout, standardize case
117154view09:44, 18 May 2021EweitzModified title
106630view20:55, 12 September 2019KhanspersModified description
105636view05:05, 10 August 2019KhanspersModified description
96169view12:30, 22 February 2018Mkutmonadded link from PLIN1 to HSL
96168view12:20, 22 February 2018MkutmonUpdated layout and complexes
95533view09:16, 21 December 2017EgonwAdded a recent protein found that inhibits ATGL.
94914view00:11, 13 October 2017KhanspersModified description
94741view15:09, 5 October 2017Mkutmonfix unconnected line
91544view06:35, 10 March 2017EgonwAdded the last few metabolite IDs.
91543view20:15, 9 March 2017EgonwAdded a few metabolite IDs.
91542view18:53, 9 March 2017EgonwTypo.
91437view20:06, 24 February 2017SusanOntology Term : 'lipid metabolic pathway' added !
91436view20:05, 24 February 2017SusanOntology Term : 'obesity' added !
91435view20:04, 24 February 2017SusanOntology Term : 'white fat cell' added !
91400view08:03, 20 February 2017MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABHD5GeneProductENSG00000011198 (Ensembl)
ACACAGeneProductENSG00000278540 (Ensembl)
ACLYGeneProductENSG00000131473 (Ensembl)
ACSBG1GeneProductENSG00000103740 (Ensembl)
ACSS2GeneProductENSG00000131069 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
ATGLGeneProductENSG00000177666 (Ensembl)
AcetateMetaboliteCHEBI:30089 (ChEBI)
AcetylCoA(cyt)MetaboliteCHEBI:15351 (ChEBI)
AcetylCoA(mit)MetaboliteCHEBI:15351 (ChEBI)
BCAAMetaboliteCHEBI:22918 (ChEBI)
BCFAMetaboliteCHEBI:35819 (ChEBI)
BCKDHAGeneProductENSG00000248098 (Ensembl)
CitrateMetaboliteCHEBI:35804 (ChEBI)
DAGMetaboliteCHEBI:18035 (ChEBI)
FASNGeneProductENSG00000169710 (Ensembl)
Fatty acid elongationPathway
FreeFAMetaboliteCHEBI:35366 (ChEBI)
Glycerolipid metabolismPathway
Glycerophospholipid metabolismPathway
HSLGeneProductENSG00000079435 (Ensembl)
MAGMetaboliteCHEBI:17408 (ChEBI)
MalonylCoAMetaboliteCHEBI:15531 (ChEBI)
PDHA1GeneProductENSG00000131828 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKAR1BGeneProductENSG00000188191 (Ensembl)
PRKAR2AGeneProductENSG00000114302 (Ensembl)
PRKAR2BGeneProductENSG00000005249 (Ensembl)
PalimitateMetaboliteCHEBI:15756 (ChEBI)
PalimitateCoAMetaboliteCHEBI:15525 (ChEBI)
PyruvateMetaboliteCHEBI:15361 (ChEBI)
TAGMetaboliteCHEBI:17855 (ChEBI)

Annotated Interactions

No annotated interactions

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